Gene: Slc25a21

Order

Name solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

Synonyms 9930033G19Rik

Status ES CellsMice
tm1b
Mice
tm1c
Mice
tm1d
Mice
tm1a
phenotype data available

Links MGI:2445059    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Slc25a21

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Slc25a21 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Slc25a21tm1a(KOMP)Wtsi HOM Female Male n/a 0.0
decreased body weight Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 3.03E-24
abnormal joint morphology Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 7.22E-12
abnormal snout morphology Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 6.07E-11
abnormal cranium morphology Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 1.72E-10
decreased total body fat amount Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 3.09E-10
absent pinna reflex Slc25a21tm1a(KOMP)Wtsi HOM Male postnatal 6.03E-10
decreased bone mineral density Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 2.15E-9
decreased circulating alanine transaminase level Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 1.73E-8
decreased circulating aspartate transaminase level Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 4.99E-8
decreased mean corpuscular volume Slc25a21tm1d(KOMP)Wtsi HOM Female Male postnatal 8.77E-8
abnormal tooth morphology Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 2.04E-7
decreased bone mineral content Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 5.03E-7
abnormal mandible morphology Slc25a21tm1a(KOMP)Wtsi HOM Female postnatal 2.57E-6
decreased NK T cell number Slc25a21tm1d(KOMP)Wtsi HOM Male postnatal 6.82E-6
decreased mean corpuscular hemoglobin Slc25a21tm1d(KOMP)Wtsi HOM Female Male postnatal 1.09E-5
decreased bone mineral content Slc25a21tm1d(KOMP)Wtsi HOM Female Male postnatal 3.05E-5
decreased lean body mass Slc25a21tm1a(KOMP)Wtsi HOM Female postnatal 3.23E-5
increased total body fat amount Slc25a21tm1d(KOMP)Wtsi HOM Female Male postnatal 3.4E-5
decreased body length Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 5.04E-5
abnormal incisor morphology Slc25a21tm1a(KOMP)Wtsi HOM Male postnatal 5.32E-5
decreased effector memory CD8-positive, alpha-beta T cell number Slc25a21tm1a(KOMP)Wtsi HOM Female Male postnatal 8.29E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 6 No
Aorta 6 No
Blood vessel 6 No
Bone 6 No
Brain 6 No (2/10)
Brainstem 6 No
Brown adipose tissue 6 No
Cartilage tissue 6 No
Cerebellum 6 No
Cerebral cortex 6 No
Eye 6 No
Gall bladder 6 No
Heart 6 No
Hippocampus 6 No
Hypothalamus 6 No
Kidney 6 No (18/584)
Large intestine 6 No (10/584)
Liver 6 No
Lower urinary tract 6 No
Lung 6 No
Lymph node 6 No
Mammary gland 6 No
Esophagus 6 No
Olfactory lobe 6 No
Ovary 6 No (1/584)
Oviduct 6 No
Pancreas 6 No (5/584)
Parathyroid gland 6 No (2/10)
Peripheral nervous system 6 No
Peyer's patch 6 No
Pituitary gland 6 No
Prostate gland 6 No (12/584)
Skeletal muscle tissue 6 No
Skin 6 No
Small intestine 6 No (9/584)
Spinal cord 6 No
Spleen 6 No (2/584)
Stomach 6 No (12/584)
Striatum 6 No
Testis 6 No (2/584) (2/10)
Thymus 6 No
Thyroid gland 6 No (15/584)
Trachea 6 No
Uterus 6 No
White adipose tissue 6 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system nervous system reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (6)
  • Slc25a21tm1b(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Slc25a21tm1b(KOMP)Wtsi
    thyroid gland, HET, Male, WTSI
  • Slc25a21tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI

show all 6 images

trunk (4)
  • Slc25a21tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    ovary, HOM, Female, WTSI
reproductive system (3)
  • Slc25a21tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    ovary, HOM, Female, WTSI
endocrine system (1)
  • Slc25a21tm1b(KOMP)Wtsi
    thyroid gland, HET, Male, WTSI
nervous system (1)
  • Slc25a21tm1b(KOMP)Wtsi
    brain, HET, Female, WTSI
urinary system (1)
  • Slc25a21tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    40 Images
  • X-ray: XRay Images Lateral Orientation
    24 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
  • X-ray: XRay Images Forepaw
    13 Images
Legacy Phenotype Associated Images
Xray (276)
  • Slc25a21tm1a(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    HOM, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    body, HOM, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    body, HOM, Female, WTSI

show all 276 images

Dysmorphology (5)
  • Slc25a21tm1a(KOMP)Wtsi
    abnormal incisor color, abnormal incisor morphology, HOM, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    abnormal incisor morphology, abnormal incisor color, HOM, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    abnormal incisor color, abnormal incisor morphology, HOM, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    abnormal incisor morphology, abnormal incisor color, HOM, Female, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    abnormal incisor color, abnormal incisor morphology, HOM, Female, WTSI
Skin Histopathology (4)
  • Slc25a21tm1b(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Slc25a21tm1b(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Slc25a21tm1d(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Slc25a21tm1d(KOMP)Wtsi
    back skin, HOM, Female, WTSI
Eye Morphology (2)
  • Slc25a21tm1d(KOMP)Wtsi
    abnormal pupil morphology, HOM, Male, WTSI
  • Slc25a21tm1a(KOMP)Wtsi
    eye, eyelids fail to open, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Slc25a21tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Slc25a21tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene
Slc25a21tm1d(KOMP)Wtsi Deletion allele (post-Flp and Cre with no reporter)
Vector
Gene
Slc25a21tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Slc25a21tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Slc25a21tm41920(L1L2_Pgk_PM)
Vector
Gene