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Gene: Lrig2 MGI:2443718

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
leucine-rich repeats and immunoglobulin-like domains 2
Synonyms:
4632419I10Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lrig2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lrig2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Urofacial Syndrome 2
OMIM:615112
Ochoa Syndrome
ORPHA:2704

The table below shows human diseases predicted to be associated to Lrig2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Deafness, Autosomal Recessive 9
Absent brainstem auditory responses, Sensorineural hearing impairment OMIM:601071
Auditory Neuropathy, Autosomal Dominant 1
Sensorineural hearing impairment, Abnormal auditory evoked potentials OMIM:609129
Deafness, Autosomal Recessive 104
Absent brainstem auditory responses, Prelingual sensorineural hearing impairment OMIM:616515
Methylmalonic Acidemia With Homocystinuria
Lethargy, Failure to thrive, Skin rash ORPHA:26
Charcot-Marie-Tooth Disease, Type 4B1
Decreased motor nerve conduction velocity, Facial palsy, Abnormal auditory evoked potentials OMIM:601382
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Lethargy, Failure to thrive ORPHA:79283
Homocystinuria Without Methylmalonic Aciduria
Lethargy, Failure to thrive ORPHA:622
Dystonia 31
Abnormal posturing, Depression OMIM:619565
Optic Atrophy 8
Sensorineural hearing impairment, Optic atrophy, Prolonged somatosensory evoked potentials, Abnor... OMIM:616648
Developmental And Epileptic Encephalopathy 40
Lethargy, Small for gestational age OMIM:617065
Encephalopathy, Acute, Infection-Induced (Herpes-Specific), Susceptibility To, 8
Lethargy, Herpes simplex encephalitis OMIM:617900
Hypothyroidism, Congenital, Nongoitrous, 7
Lethargy OMIM:618573
Dihydropyrimidine Dehydrogenase Deficiency
Lethargy, Failure to thrive OMIM:274270
Immunodeficiency 83, Susceptibility To Viral Infections
Lethargy, Herpes simplex encephalitis OMIM:613002
Glut1 Deficiency Syndrome 1
Lethargy, Paroxysmal lethargy OMIM:606777
Febrile Infection-Related Epilepsy Syndrome
Lethargy, Sinusitis ORPHA:163703
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 6
Bradykinesia, Lethargy OMIM:618683
Autosomal Recessive Spastic Paraplegia Type 44
Abnormal motor evoked potentials, Sensorineural hearing impairment, Abnormal auditory evoked pote... ORPHA:320401
Central Diabetes Insipidus
Lethargy, Failure to thrive, Weight loss, Depression ORPHA:178029
Short Chain Acyl-Coa Dehydrogenase Deficiency
Lethargy, Failure to thrive ORPHA:26792
Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration And Progressive Polyneuropathy Type)
Lethargy OMIM:613710
Hereditary Central Diabetes Insipidus
Lethargy, Weight loss ORPHA:30925
N-Acetylglutamate Synthase Deficiency
Lethargy, Failure to thrive OMIM:237310
Developmental And Epileptic Encephalopathy 92
Lethargy OMIM:617829
Mitochondrial Complex I Deficiency, Nuclear Type 3
Lethargy OMIM:618224
Vitamin B12-Responsive Methylmalonic Acidemia
Lethargy, Failure to thrive ORPHA:28
3-Hydroxyisobutyryl-Coa Hydrolase Deficiency
Head titubation, Lethargy, Failure to thrive OMIM:250620
Holocarboxylase Synthetase Deficiency
Alopecia, Eczema, Keratoconjunctivitis, Weight loss, Lethargy, Perioral eczema ORPHA:79242
Early Myoclonic Encephalopathy
Lethargy ORPHA:1935
Glycine Encephalopathy 1
Lethargy OMIM:605899
Combined Oxidative Phosphorylation Deficiency 2
Lethargy, Small for gestational age OMIM:610498
Mitochondrial Complex Iv Deficiency, Nuclear Type 20
Lethargy, Synophrys, Long eyelashes, Failure to thrive in infancy OMIM:619064
Gaba-Transaminase Deficiency
Lethargy OMIM:613163
Lethal Infantile Mitochondrial Myopathy
Lethargy ORPHA:254857
Ravine Syndrome
Abnormal auditory evoked potentials ORPHA:99852
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 2
Lethargy, Failure to thrive OMIM:613561
Huntington Disease-Like 1
Bradykinesia, Abnormal posturing, Weight loss, Depression ORPHA:157941
Severe Canavan Disease
Lethargy ORPHA:314911
Idiopathic Intracranial Hypertension
Lethargy, Obesity, Depression ORPHA:238624
Hypercalcemia, Infantile, 1
Lethargy, Failure to thrive, Weight loss OMIM:143880
Mitochondrial Complex I Deficiency, Nuclear Type 6
Lethargy, Failure to thrive OMIM:618228
Crigler-Najjar Syndrome
Lethargy, Infectious encephalitis ORPHA:205
Neurodevelopmental Disorder With Hypotonia, Neuropathy, And Deafness
Absent brainstem auditory responses, Sensorineural hearing impairment, Facial palsy, EEG abnormality OMIM:617519
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Lethargy, Increased body weight ORPHA:276608
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-
Lethargy, Failure to thrive, Pancreatitis ORPHA:79312
Classic Glucose Transporter Type 1 Deficiency Syndrome
Lethargy ORPHA:71277
Pontocerebellar Hypoplasia, Type 6
Lethargy, Failure to thrive OMIM:611523
Hemochromatosis, Type 2A
Arthritis, Lethargy OMIM:602390
Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy
Progressive sensorineural hearing impairment, Optic atrophy, Abnormal auditory evoked potentials OMIM:125250
Abcd Syndrome
Hearing impairment, Aganglionic megacolon, Abnormal auditory evoked potentials, Total intestinal ... OMIM:600501
Hyperlysinuria With Hyperammonemia
Lethargy OMIM:238750
Pyruvate Dehydrogenase E1-Alpha Deficiency
Lethargy, Small for gestational age OMIM:312170
Homocystinuria-Megaloblastic Anemia, Cble Complementation Type
Lethargy, Failure to thrive OMIM:236270
Mitochondrial Complex I Deficiency, Nuclear Type 5
Lethargy, Failure to thrive OMIM:618226
Methylmalonic Aciduria And Homocystinuria, Cblj Type
Lethargy, Abnormal posturing, Failure to thrive OMIM:614857
Combined Oxidative Phosphorylation Deficiency 52
Lethargy, Pancreatitis OMIM:619386
Hyperinsulinism Due To Hnf1A Deficiency
Lethargy, Small for gestational age, Large for gestational age ORPHA:324575
Dihydrolipoamide Dehydrogenase Deficiency
Lethargy OMIM:246900
Glutaric Acidemia Type 3
Lethargy, Failure to thrive ORPHA:35706
Riboflavin Deficiency
Lethargy OMIM:615026
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome
Acute hepatitis, Failure to thrive, Lethargy OMIM:238970
Mitochondrial Complex I Deficiency, Nuclear Type 4
Lethargy OMIM:618225
Dihydropyrimidinase Deficiency
Lethargy OMIM:222748
Autosomal Recessive Dopa-Responsive Dystonia
Bradykinesia, Lethargy ORPHA:101150
Classic Pantothenate Kinase-Associated Neurodegeneration
Abnormal posturing, Aspiration pneumonia, Weight loss ORPHA:216866
Mohr-Tranebjaerg Syndrome
Abnormal posturing OMIM:304700
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Lethargy, Failure to thrive, Myelodysplasia ORPHA:927
Hyperinsulinism Due To Ucp2 Deficiency
Lethargy, Large for gestational age ORPHA:276556
Central Neurocytoma
Lethargy, Depression ORPHA:73256
Benign Samaritan Congenital Myopathy
Lethargy ORPHA:324581
Pyruvate Dehydrogenase E3 Deficiency
Lethargy, Failure to thrive ORPHA:2394
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0
Lethargy, Pancreatitis ORPHA:289916
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Lethargy OMIM:610006
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Lethargy, Large for gestational age ORPHA:276575
Propionic Acidemia
Pancreatitis, Failure to thrive, Eczema, Lethargy OMIM:606054
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Lethargy, Large for gestational age ORPHA:276580
Leukoencephalopathy With Vanishing White Matter 1
Lethargy OMIM:603896
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
Lethargy, Failure to thrive ORPHA:2089
Typhoid
Skin rash, Lethargy, Infectious encephalitis ORPHA:99745
Citrullinemia Type I
Lethargy, Failure to thrive ORPHA:247525
Hjv Or Hamp-Related Hemochromatosis
Lethargy ORPHA:79230
Charcot-Marie-Tooth Disease, Type 4C
Decreased motor nerve conduction velocity, Prolonged brainstem auditory evoked potentials, Facial... OMIM:601596
Insulinoma
Increased body weight, Neoplasm of the adrenal gland, Pituitary prolactin cell adenoma, Lethargy,... ORPHA:97279
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency
Tubulointerstitial nephritis, Failure to thrive, Pancreatitis, Lethargy OMIM:251000
Scrub Typhus
Anterior uveitis, Skin rash, Myocarditis, Lethargy, Infectious encephalitis ORPHA:83317
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Lethargy, Failure to thrive OMIM:611590
Thyroid Dyshormonogenesis 1
Lethargy OMIM:274400
Carbamoyl Phosphate Synthetase I Deficiency, Hyperammonemia Due To
Lethargy, Failure to thrive OMIM:237300
Cyclic Vomiting Syndrome
Lethargy OMIM:500007
Vitamin B12-Unresponsive Methylmalonic Acidemia
Lethargy, Pancreatitis ORPHA:27
Carnitine Deficiency, Systemic Primary
Lethargy, Failure to thrive OMIM:212140
Susac Syndrome
Lethargy, Apathy ORPHA:838
Thiamine-Responsive Megaloblastic Anemia Syndrome
Lethargy ORPHA:49827
Charcot-Marie-Tooth Disease, Type 4D
Decreased nerve conduction velocity, Sensorineural hearing impairment, Abnormal auditory evoked p... OMIM:601455
Medium Chain Acyl-Coa Dehydrogenase Deficiency
Lethargy, Cachexia ORPHA:42
Hyperphenylalaninemia, Bh4-Deficient, B
Lethargy OMIM:233910
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 5
Lethargy OMIM:618120
Idiopathic Congenital Hypothyroidism
Lethargy ORPHA:95717
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
Lethargy, Alopecia, Failure to thrive, Seborrheic dermatitis OMIM:210210
Mitochondrial Complex Iii Deficiency, Nuclear Type 8
Lethargy, Failure to thrive OMIM:615838
Biotinidase Deficiency
Alopecia, Skin rash, Recurrent skin infections, Seborrheic dermatitis, Conjunctivitis, Lethargy OMIM:253260
Pyruvate Dehydrogenase Deficiency
Lethargy, Multiple lipomas ORPHA:765
Classic Galactosemia
Lethargy, Depression ORPHA:79239
Maple Syrup Urine Disease
Lethargy, Pancreatitis OMIM:248600
Autosomal Dominant Optic Atrophy Plus Syndrome
Temporal optic disc pallor, Absent brainstem auditory responses, Sensorineural hearing impairment... ORPHA:1215
Developmental And Epileptic Encephalopathy 41
Lethargy OMIM:617105
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency
Lethargy, Failure to thrive OMIM:210200
Isovaleric Acidemia
Lethargy OMIM:243500
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Inflammatory abnormality of the skin, Small for gestational age, Pneumonia, Overweight, Obesity, ... ORPHA:26793
Methylmalonic Acidemia With Homocystinuria Type Cblf
Stomatitis, Lethargy, Failure to thrive, Skin rash ORPHA:79284
Sporadic Infantile Bilateral Striatal Necrosis
Bradykinesia, Abnormal posturing, Titubation ORPHA:225147
Dystonia 1, Torsion, Autosomal Dominant
Abnormal posturing, Depression OMIM:128100
Methylmalonic Aciduria And Homocystinuria, Cblf Type
Skin rash, Small for gestational age, Stomatitis, Lethargy, Failure to thrive OMIM:277380
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Lethargy OMIM:600649
Meningococcal Meningitis
Skin rash, Lethargy, Infectious encephalitis ORPHA:33475
Mohr-Tranebjaerg Syndrome
Absent brainstem auditory responses, Sensorineural hearing impairment, Optic atrophy, Prelingual ... ORPHA:52368
Congenital Disorder Of Glycosylation, Type Ig
Lethargy, Failure to thrive, Recurrent pneumonia, Small for gestational age OMIM:607143
Necrotizing Enterocolitis
Lethargy, Peritonitis, Small for gestational age ORPHA:391673
Multifocal Atrial Tachycardia
Lethargy ORPHA:3282
Holocarboxylase Synthetase Deficiency
Lethargy, Alopecia, Skin rash OMIM:253270
Mitochondrial Trifunctional Protein Deficiency 1
Lethargy, Failure to thrive, Small for gestational age OMIM:609015
Mitochondrial Complex I Deficiency, Nuclear Type 9
Lethargy OMIM:618232
Multiple Mitochondrial Dysfunctions Syndrome 1
Lethargy, Failure to thrive OMIM:605711
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Lethargy, Increased body weight, Large for gestational age ORPHA:263455
Methylcobalamin Deficiency Type Cble
Lethargy, Failure to thrive ORPHA:2169
Symptomatic Form Of Hfe-Related Hemochromatosis
Arthritis, Apathy, Lethargy, Weight loss ORPHA:465508
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Lethargy, Failure to thrive, Alopecia of scalp OMIM:201100
Dengue Fever
Lethargy, Skin rash ORPHA:99828
Evans Syndrome
Lethargy ORPHA:1959
Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations
Optic disc pallor, Abnormal auditory evoked potentials OMIM:617523
Isolated Atp Synthase Deficiency
Lethargy ORPHA:254913
Infantile Liver Failure Syndrome 2
Lethargy OMIM:616483
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia
Lethargy OMIM:614299
Thiamine Metabolism Dysfunction Syndrome 2 (Biotin- Or Thiamine-Responsive Type)
Truncal titubation, Lethargy OMIM:607483
Citrullinemia Type Ii
Lethargy, Mania, Pancreatitis, Decreased body mass index ORPHA:247585
Ogden Syndrome
Lethargy, Aplasia/Hypoplasia of the eyebrow, Fine hair ORPHA:276432
Carnitine Palmitoyl Transferase 1A Deficiency
Lethargy ORPHA:156
Staphylococcal Necrotizing Pneumonia
Acute infectious pneumonia, Lethargy, Pneumonia ORPHA:36238
Argininosuccinic Aciduria
Dry hair, Brittle hair, Lethargy, Failure to thrive, Trichorrhexis nodosa OMIM:207900
Resistance To Thyrotropin-Releasing Hormone Syndrome
Overweight, Lethargy, Depression ORPHA:99832
Late-Onset Isolated Acth Deficiency
Pituitary adenoma, Hepatitis, Weight loss, Lethargy, Failure to thrive, Hashimoto thyroiditis ORPHA:199299
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Lethargy, Necrotizing enterocolitis OMIM:201475
Axenfeld-Rieger Anomaly With Partially Absent Eye Muscles, Distinctive Face, Hydrocephaly, And Skeletal Abnormalities
Sensorineural hearing impairment, Abnormal auditory evoked potentials OMIM:109120
Familial Thyroid Dyshormonogenesis
Lethargy ORPHA:95716
Mitochondrial Complex Iv Deficiency, Nuclear Type 2
Lethargy OMIM:604377
Ebola Hemorrhagic Fever
Lethargy, Acute pancreatitis, Maculopapular exanthema, Hepatitis ORPHA:319218
Sim1-Related Prader-Willi-Like Syndrome
Hypopigmentation of hair, Obesity, Abdominal obesity, Lethargy, Failure to thrive ORPHA:398079
Sandifer Syndrome
Abnormal posturing, Esophagitis ORPHA:71272
Renal Hypoplasia, Bilateral
Lethargy, Failure to thrive, Small for gestational age ORPHA:97362
Multiple Endocrine Neoplasia Type 1
Angiofibromas, Pituitary corticotropic cell adenoma, Pituitary gonadotropic cell adenoma, Pancrea... ORPHA:652
Carnitine Palmitoyltransferase I Deficiency
Lethargy OMIM:255120
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of
Lethargy OMIM:201450
Spondyloepiphyseal Dysplasia, Sensorineural Hearing Loss, Impaired Intellectual Development, And Leber Congenital Amaurosis
Optic disc pallor, Sensorineural hearing impairment, Abnormal auditory evoked potentials OMIM:619260
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Recurrent otitis media, Lethargy, Failure to thrive, Bronchiectasis OMIM:620233
Medulloblastoma
Medulloblastoma, Spinal cord tumor, Neoplasm of the lung, Lethargy, Neuroblastoma, Cerebellar med... ORPHA:616
Acyl-Coa Dehydrogenase, Short-Chain, Deficiency Of
Lethargy, Failure to thrive OMIM:201470
Biotinidase Deficiency
Alopecia, Skin rash, Conjunctivitis, Lethargy, Eczematoid dermatitis ORPHA:79241
Methylmalonic Aciduria, Cblb Type
Lethargy, Failure to thrive OMIM:251110
3-Hydroxy-3-Methylglutaric Aciduria
Lethargy, Acute pancreatitis, Apathy, Weight loss ORPHA:20
Transcobalamin Ii Deficiency
Lethargy, Failure to thrive OMIM:275350
Magel2-Related Prader-Willi-Like Syndrome
Hypopigmentation of hair, Increased body weight, Abdominal obesity, Lethargy, Failure to thrive ORPHA:398069
Cirrhosis, Familial
Lethargy, Fulminant hepatitis OMIM:215600
Familial Hypoaldosteronism
Lethargy, Failure to thrive ORPHA:427
Pseudo-Torch Syndrome 2
Lethargy OMIM:617397
Late-Infantile/Juvenile Krabbe Disease
Decreased nerve conduction velocity, Prolonged brainstem auditory evoked potentials, EEG with per... ORPHA:206443
Mitochondrial Trifunctional Protein Deficiency
Lethargy, Failure to thrive in infancy ORPHA:746
Combined Oxidative Phosphorylation Deficiency 11
Lethargy OMIM:614922
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Lethargy, Failure to thrive ORPHA:71212
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Lethargy, Skin rash OMIM:618321
Methylmalonic Aciduria, Cbla Type
Lethargy, Failure to thrive OMIM:251100
Fructose-1,6-Bisphosphatase Deficiency
Lethargy OMIM:229700
Carnitine-Acylcarnitine Translocase Deficiency
Lethargy OMIM:212138
Citrullinemia, Classic
Lethargy, Failure to thrive OMIM:215700
Autosomal Dominant Progressive External Ophthalmoplegia
Bipolar affective disorder, Depression, Bradykinesia, Lethargy, Failure to thrive ORPHA:254892
Vici Syndrome
Hypopigmentation of hair, Albinism, Chronic mucocutaneous candidiasis, Abnormal posturing, Failur... OMIM:242840
Homocystinuria Due To Methylene Tetrahydrofolate Reductase Deficiency
Lethargy, Failure to thrive ORPHA:395
Peroxisome Biogenesis Disorder 5A (Zellweger)
Lethargy, Failure to thrive, Small for gestational age, Hypoplastic nipples OMIM:614866
Isolated Thyroid-Stimulating Hormone Deficiency
Lethargy, Failure to thrive, Depression ORPHA:90674
Leukodystrophy, Hypomyelinating, 13
Prolonged brainstem auditory evoked potentials, Optic atrophy OMIM:616881
Complete Atrioventricular Septal Defect
Lethargy, Failure to thrive, Recurrent pneumonia ORPHA:1329
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Lethargy OMIM:608836
Trichinellosis
Skin rash, Lethargy, Apathy, Conjunctivitis ORPHA:863
Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To
Lethargy, Failure to thrive OMIM:311250
Methylmalonic Aciduria And Homocystinuria, Cbld Type
Lethargy OMIM:277410
Chronic Bilirubin Encephalopathy
Sensorineural hearing impairment, Abnormal auditory evoked potentials ORPHA:529808
Acute Bilirubin Encephalopathy
Sensorineural hearing impairment, Abnormal auditory evoked potentials ORPHA:529799
Pearson Marrow-Pancreas Syndrome
Lethargy, Punctate keratitis, Failure to thrive, Small for gestational age OMIM:557000
Isolated Complex I Deficiency
Lethargy, Failure to thrive ORPHA:2609
Cholera
Lethargy, Aspiration pneumonia ORPHA:173
Carnitine-Acylcarnitine Translocase Deficiency
Lethargy ORPHA:159
Arthrogryposis, Distal, Type 2A
Abnormal auditory evoked potentials, Hearing impairment OMIM:193700
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome
Lethargy, Failure to thrive, Hepatitis ORPHA:415
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Lethargy, Failure to thrive OMIM:277400
Posterior Urethral Valve
Lethargy, Pyelonephritis ORPHA:93110
Glycerol Kinase Deficiency
Lethargy, Small for gestational age, Chronic pancreatitis OMIM:307030
Aromatic L-Amino Acid Decarboxylase Deficiency
Lethargy OMIM:608643
Neurodegeneration And Seizures Due To Copper Transport Defect
Lethargy OMIM:620306
Diamond-Blackfan Anemia
Acute myeloid leukemia, Small for gestational age, Myelodysplasia, Low anterior hairline, Adenoca... ORPHA:124
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome
Absent brainstem auditory responses, Vestibular areflexia ORPHA:3240
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Stomatitis, Lethargy, Failure to thrive ORPHA:79282
Encephalitis Lethargica
Lethargy ORPHA:83600
Genetic Transient Congenital Hypothyroidism
Lethargy ORPHA:226316
Adult-Onset Autosomal Dominant Leukodystrophy
Orthostatic hypotension, EEG with generalized slow activity, Abnormal auditory evoked potentials,... ORPHA:99027
Amoebiasis Due To Free-Living Amoebae
Sinusitis, Pneumonia, Pustule, Lethargy, Infectious encephalitis ORPHA:68
Infantile Krabbe Disease
Decreased nerve conduction velocity, Prolonged brainstem auditory evoked potentials, Optic atroph... ORPHA:206436
Charcot-Marie-Tooth Disease Type 1F
Decreased nerve conduction velocity, Absent brainstem auditory responses, Sensorineural hearing i... ORPHA:101085
Mitochondrial Dna Depletion Syndrome 15 (Hepatocerebral Type)
Lethargy, Failure to thrive OMIM:617156
Adult Krabbe Disease
Prolonged brainstem auditory evoked potentials, EEG abnormality ORPHA:206448
Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To
Lethargy OMIM:615751
Hypothyroidism Due To Tsh Receptor Mutations
Lethargy ORPHA:90673
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Absent brainstem auditory responses, Aganglionic megacolon, Short-segment aganglionic megacolon, ... OMIM:609136
Mitochondrial Complex I Deficiency, Nuclear Type 1
Lethargy, Failure to thrive OMIM:252010
Semilobar Holoprosencephaly
Depression, Apathy, Aspiration pneumonia, Lethargy, Failure to thrive ORPHA:220386
Alobar Holoprosencephaly
Depression, Apathy, Aspiration pneumonia, Lethargy, Failure to thrive ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Depression, Apathy, Aspiration pneumonia, Lethargy, Failure to thrive ORPHA:93926
Lobar Holoprosencephaly
Depression, Apathy, Aspiration pneumonia, Lethargy, Failure to thrive ORPHA:93924
Lysinuric Protein Intolerance
Glomerulonephritis, Tubulointerstitial nephritis, Membranous nephropathy, Lethargy, Failure to th... ORPHA:470
Cockayne Syndrome Type 1
Absent brainstem auditory responses, Optic atrophy, Macrotia, Abnormality of peripheral nerve con... ORPHA:90321
Pineoblastoma
Lethargy, Retinoblastoma, Pinealoma ORPHA:251909
Histiocytoid Cardiomyopathy
Lethargy, Failure to thrive ORPHA:137675
Marburg Hemorrhagic Fever
Pericarditis, Skin rash, Maculopapular exanthema, Orchitis, Uveitis, Arthritis, Lethargy, Pancrea... ORPHA:99826
Trisomy 10P
Posteriorly rotated ears, Abnormal auditory evoked potentials, EEG with burst suppression, Low vo... ORPHA:171929
Hereditary Fructose Intolerance
Lethargy ORPHA:469
Mogs-Cdg
Absent brainstem auditory responses, Sensorineural hearing impairment, Optic atrophy ORPHA:79330
Cerebrotendinous Xanthomatosis
Optic disc pallor, Abnormal auditory evoked potentials, Optic neuropathy, Decreased nerve conduct... ORPHA:909
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Overweight, Lethargy ORPHA:226307
Glycine Encephalopathy
Lethargy ORPHA:407
Kufor-Rakeb Syndrome
Bradykinesia, Lethargy, Apathy ORPHA:306674
Fructose Intolerance, Hereditary
Lethargy, Failure to thrive OMIM:229600
Hydranencephaly
Lethargy ORPHA:2177
Cockayne Syndrome B
Abnormal pinna morphology, Abnormal auditory evoked potentials, Decreased nerve conduction veloci... OMIM:133540
Cockayne Syndrome A
Abnormal pinna morphology, Abnormal auditory evoked potentials, Decreased nerve conduction veloci... OMIM:216400
Unilateral Polymicrogyria
Abnormal posturing ORPHA:268943
Hypothyroidism, Congenital, Nongoitrous, 2
Lethargy OMIM:218700
Mend Syndrome
Abnormal auditory evoked potentials, Low-set ears ORPHA:401973
Exercise-Induced Malignant Hyperthermia
Lethargy ORPHA:466650
Eisenmenger Syndrome
Lethargy, Bacterial endocarditis ORPHA:97214
Paroxysmal Nocturnal Hemoglobinuria
Lethargy ORPHA:447
Ochoa Syndrome
ORPHA:2704
Urofacial Syndrome 2
OMIM:615112

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrig2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrig2.

No publications found that use IMPC mice or data for Lrig2.

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MGI Allele Allele Type Produced
Lrig2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Lrig2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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