Gene: Mcph1

Name microcephaly, primary autosomal recessive 1

Synonyms
  • BRIT1
  • D030046N04Rik
  • 5430437K10Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:2443308   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Mcph1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mcph1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
female infertility Mcph1tm1a(EUCOMM)Wtsi HOM Female postpartum stage 0.0
male infertility Mcph1tm1a(EUCOMM)Wtsi HOM Male postpartum stage 0.0
absent pinna reflex Mcph1tm1a(EUCOMM)Wtsi HOM Female postnatal 9.2E-7
abnormal cornea morphology Mcph1tm1a(EUCOMM)Wtsi HOM Female postnatal 2.87E-6
decreased lean body mass Mcph1tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.62E-6
decreased bone mineral density Mcph1tm1a(EUCOMM)Wtsi HOM Female postnatal 6.61E-6
abnormal behavior Mcph1tm1a(EUCOMM)Wtsi HOM Female postnatal 7.82E-6
corneal opacity Mcph1tm1a(EUCOMM)Wtsi HOM Female postnatal 3.75E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539) (1/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540) (1/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system nervous system reproductive system musculoskeletal system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
nervous system (4)
  • Mcph1tm1a(EUCOMM)Wtsi
    BRAIN, HET, Male, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    BRAIN, HET, Male, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
trunk (3)
  • Mcph1tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    OVARY, HET, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
reproductive system (2)
  • Mcph1tm1a(EUCOMM)Wtsi
    TESTIS, HET, Male, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    OVARY, HET, Female, WTSI
endocrine system (1)
  • Mcph1tm1a(EUCOMM)Wtsi
    PARATHYROID GLAND, HET, Male, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (236)
  • Mcph1tm1a(EUCOMM)Wtsi
    TRUNK, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    TRUNK, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    HEAD, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    HEAD, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI

show all 236 images

Eye Morphology (11)
  • Mcph1tm1a(EUCOMM)Wtsi
    EYE, corneal opacity, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    EYE, cornea/lens fusion, corneal vascularization, corneal opacity, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    EYE, persistence of hyaloid vascular system, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    EYE, corneal opacity, cornea/lens fusion, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    EYE, cornea/lens fusion, corneal opacity, HOM, Female, WTSI

show all 11 images

Skin Histopathology (4)
  • Mcph1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI
  • Mcph1tm1a(EUCOMM)Wtsi
    FOOT DIGIT 4, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mcph1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene