Gene: Casc4

Name cancer susceptibility candidate 4

Synonyms D130060C09Rik

Status ES CellsMice
tm2a
Mice
tm2b
phenotype data available

Links MGI:2443129   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Casc4

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Casc4 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased anti-nuclear antigen antibody level Casc4tm2b(EUCOMM)Wtsi HOM Female Male postnatal 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No (4/4)
Aorta 3 No (1/562) (4/4)
Blood vessel 3 No
Bone 3 No (1/539)
Brain 3 No (5/562) (4/4)
Brainstem 3 No (4/562) (4/4)
Brown adipose tissue 3 No
Cartilage tissue 3 No (1/562)
Cerebellum 3 No (4/562) (4/4)
Cerebral cortex 3 No (5/562) (4/4)
Eye 3 No (1/562)
Gall bladder 3 No (1/4)
Heart 3 No (3/562) (4/4)
Hippocampus 3 No (5/562) (4/4)
Hypothalamus 3 No (4/562) (4/4)
Kidney 3 No (19/562) (4/4)
Large intestine 3 No (12/562) (1/4)
Liver 3 No
Lower urinary tract 3 No (3/562) (2/4)
Lung 3 No (3/562) (4/4)
Lymph node 3 No (1/562)
Mammary gland 3 No
Esophagus 3 No
Olfactory lobe 3 No (1/4)
Ovary 3 No (1/562) (1/4)
Oviduct 3 No (2/562) (2/4)
Pancreas 3 No (6/562)
Parathyroid gland 3 No (2/540) (4/4)
Peripheral nervous system 3 No (3/562) (4/4)
Peyer's patch 3 No
Pituitary gland 3 No (1/562) (4/4)
Prostate gland 3 No (5/562)
Skeletal muscle tissue 3 No
Skin 3 No (1/562)
Small intestine 3 No (11/562) (1/4)
Spinal cord 3 No (3/562) (4/4)
Spleen 3 No (4/562)
Stomach 3 No (9/562) (1/4)
Striatum 3 No (4/562) (4/4)
Testis 3 No (3/562) (2/4)
Thymus 3 No
Thyroid gland 3 No (16/562) (1/4)
Trachea 3 No (3/562) (3/4)
Uterus 3 No (2/562) (2/4)
White adipose tissue 3 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse respiratory system digestive system cardiovascular system nervous system reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (20)
  • Casc4tm2b(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    LUNG, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    TRACHEA, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    UTERUS, HET, Female, WTSI

show all 20 images

digestive system (6)
  • Casc4tm2b(EUCOMM)Wtsi
    SMALL INTESTINE, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    STOMACH, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    GALL BLADDER, HOM, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    ESOPHAGUS, HOM, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    SMALL INTESTINE, HOM, Male, WTSI

show all 6 images

nervous system (4)
  • Casc4tm2b(EUCOMM)Wtsi
    TRIGEMINAL V NERVE, PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    SPINAL CORD, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    STRIATUM, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    BRAINSTEM, HOM, Male, WTSI
reproductive system (3)
  • Casc4tm2b(EUCOMM)Wtsi
    UTERUS, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    TESTIS, HOM, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    PROSTATE GLAND, HOM, Male, WTSI
respiratory system (3)
  • Casc4tm2b(EUCOMM)Wtsi
    LUNG, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    TRACHEA, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    TRACHEA, HOM, Male, WTSI
cardiovascular system (2)
  • Casc4tm2b(EUCOMM)Wtsi
    AORTA, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    AORTA, HOM, Male, WTSI
urinary system (2)
  • Casc4tm2b(EUCOMM)Wtsi
    KIDNEY, HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
endocrine system (1)
  • Casc4tm2b(EUCOMM)Wtsi
    ADRENAL GLAND, HET, Female, WTSI
exocrine system (1)
  • Casc4tm2b(EUCOMM)Wtsi
    PROSTATE GLAND, HOM, Male, WTSI
immune system (1)
  • Casc4tm2b(EUCOMM)Wtsi
    THYMUS, HOM, Male, WTSI
musculoskeletal system (1)
  • Casc4tm2b(EUCOMM)Wtsi
    CARTILAGE TISSUE, RIB, HOM, Male, WTSI
set of connective tissues (1)
  • Casc4tm2b(EUCOMM)Wtsi
    CARTILAGE TISSUE, RIB, HOM, Male, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    20 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    31 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Anti-nuclear antibody assay
    13 Images
Legacy Phenotype Associated Images
Xray (51)
  • Casc4tm2b(EUCOMM)Wtsi
    HOM, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HOM, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HOM, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HOM, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HOM, Female, WTSI

show all 51 images

Histology Slide (7)
  • Casc4tm2b(EUCOMM)Wtsi
    HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HET, Male, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HET, Female, WTSI
  • Casc4tm2b(EUCOMM)Wtsi
    HET, Female, WTSI

show all 7 images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Casc4tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Casc4tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Casc4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene