Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Brain | Wholemount images | heterozygote | 100% (4 of 4) |
Colon | Wholemount images | heterozygote | 50% (2 of 4) |
Epididymis | Section images | heterozygote | 50% (2 of 4) |
Eye | Section images | heterozygote | 25% (1 of 4) |
Harderian gland | Wholemount images | heterozygote | 25% (1 of 4) |
Ileum | Wholemount images Section images | heterozygote | 50% (2 of 4) |
Jejunum | Wholemount images | heterozygote | 50% (2 of 4) |
Midbrain | Wholemount images Section images | heterozygote | 100% (4 of 4) |
Olfactory lobe | Section images | heterozygote | 75% (3 of 4) |
Parathyroid gland | Wholemount images | heterozygote | 50% (2 of 4) |
Prostate gland | Section images | heterozygote | 25% (1 of 4) |
Spinal cord | Wholemount images | heterozygote | 50% (2 of 4) |
Thyroid gland | Wholemount images | heterozygote | 25% (1 of 4) |
Tongue | Section images | heterozygote | 50% (2 of 4) |
Uterus | Section images | heterozygote | 25% (1 of 4) |
Vas deferens | Section images | heterozygote | 50% (2 of 4) |
Adrenal gland | N/A | heterozygote | 0.0% (0 of 4) |
Aorta | N/A | heterozygote | 0.0% (0 of 4) |
Blood | N/A | heterozygote | 0.0% (0 of 4) |
Bone marrow | N/A | heterozygote | 0.0% (0 of 4) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Cartilage tissue | N/A | heterozygote | Not available |
Cecum | N/A | heterozygote | 50% (2 of 4) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 4) |
Cerebral cortex | N/A | heterozygote | Not available |
Chest bone | N/A | heterozygote | Not available |
Diaphragm | N/A | heterozygote | 0.0% (0 of 4) |
Duodenum | N/A | heterozygote | 0.0% (0 of 4) |
Esophagus | N/A | heterozygote | 0.0% (0 of 4) |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 4) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Kidney | N/A | heterozygote | 25% (1 of 4) |
Large intestine | N/A | heterozygote | 50% (2 of 4) |
Liver | N/A | heterozygote | 0.0% (0 of 4) |
Lower urinary tract | N/A | heterozygote | Not available |
Lung | N/A | heterozygote | 0.0% (0 of 4) |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Ovary | N/A | heterozygote | 0.0% (0 of 4) |
Oviduct | N/A | heterozygote | 0.0% (0 of 4) |
Pancreas | N/A | heterozygote | 0.0% (0 of 4) |
Parotid gland | N/A | heterozygote | 0.0% (0 of 4) |
Penis | N/A | heterozygote | 0.0% (0 of 4) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 4) |
Quadriceps | N/A | heterozygote | 0.0% (0 of 4) |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 4) |
Skeletal muscle | N/A | heterozygote | Not available |
Skin | N/A | heterozygote | 0.0% (0 of 4) |
Small intestine | N/A | heterozygote | 75% (3 of 4) |
Spleen | N/A | heterozygote | 0.0% (0 of 4) |
Stomach pyloric region | N/A | heterozygote | Not available |
Stomach | N/A | heterozygote | 50% (2 of 4) |
Striatum | N/A | heterozygote | Not available |
Sublingual gland | N/A | heterozygote | 0.0% (0 of 4) |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 4) |
Testis | N/A | heterozygote | 0.0% (0 of 4) |
Thymus | N/A | heterozygote | 0.0% (0 of 4) |
Trachea | N/A | heterozygote | 0.0% (0 of 4) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 4) |
Urinary bladder | N/A | heterozygote | 0.0% (0 of 4) |
Vagina | N/A | heterozygote | 0.0% (0 of 4) |
Vascular system | N/A | heterozygote | Not available |
Vesicular gland | N/A | heterozygote | 0.0% (0 of 4) |
White adipose tissue | N/A | heterozygote | Not available |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Mtnr1b by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Type 2 Diabetes Mellitus | Insulin resistance, Type II diabetes mellitus | OMIM:125853 |
The table below shows human diseases predicted to be associated to Mtnr1b by phenotypic similarity.
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
Phenotype | Allele | Zygosity | Sex | Life Stage |
---|---|---|---|---|
Eye - MPATH pathological entity term cataract; nuclear and cortical | Mtnr1btm1.1(KOMP)Vlcg | HOM | Early adult |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mtnr1b.
There are 3 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Major role of MT2 receptors in the beneficial effect of melatonin on long-term recognition memory in C57BL/6J male mice. | Hormones and behavior (October 2021) | Mtnr1btm1.1(KOMP)Vlcg | 34634697 |
MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations. | Journal of pineal research (April 2019) | Mtnr1btm1.1(KOMP)Vlcg | 30937953 |
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. | PLoS genetics (February 2016) | Mtnr1btm1(KOMP)Vlcg | PMC4739719 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Mtnr1btm364325(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Mtnr1btm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Mtnr1btm450965(Ifitm2_intron_L1L2_GT2_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Mtnr1btm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Mtnr1btm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Mtnr1btm1aWtsi | KO first allele (reporter-tagged insertion with conditional potential) | ES Cells |
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