Gene: Akap9

Order

Name A kinase (PRKA) anchor protein (yotiao) 9

Synonyms
  • G1-448-15
  • mei2-5
  • repro12
  • AKAP450
  • 5730481H23Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:2178217    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Akap9

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Akap9 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Akap9tm1a(KOMP)Wtsi HOM Female Male n/a 0.0
decreased circulating HDL cholesterol level Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 1.41E-16
decreased circulating LDL cholesterol level Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 3.79E-11
decreased circulating cholesterol level Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 3.76E-10
decreased circulating serum albumin level Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 2.32E-9
decreased total body fat amount Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 1.09E-8
decreased body weight Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 4.83E-8
decreased circulating total protein level Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 5.3E-8
decreased circulating fructosamine level Akap9tm1a(KOMP)Wtsi HET Male postnatal 2.28E-7
increased circulating fructosamine level Akap9tm1a(KOMP)Wtsi HET Female postnatal 2.28E-7
abnormal head morphology Akap9tm1a(KOMP)Wtsi HET Male postnatal 3.31E-6
decreased body weight Akap9tm1a(KOMP)Wtsi HOM Female postnatal 4.96E-6
decreased circulating calcium level Akap9tm1a(KOMP)Wtsi HET Female Male postnatal 1.1E-5
increased bone mineral density Akap9tm1a(KOMP)Wtsi HET Male postnatal 9.18E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No (1/2)
Gall bladder 2 No
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (1/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No (2/2)
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (20)
  • Akap9tm1a(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI

show all 20 images

trunk (11)
  • Akap9tm1a(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Akap9tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI

show all 11 images

nervous system (4)
  • Akap9tm1a(KOMP)Wtsi
    pituitary gland, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    spinal cord, HET, Female, WTSI
digestive system (3)
  • Akap9tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
integumental system (2)
  • Akap9tm1a(KOMP)Wtsi
    pinna, skin, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    skin, HET, Female, WTSI
musculoskeletal system (2)
  • Akap9tm1a(KOMP)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
reproductive system (2)
  • Akap9tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Akap9tm1a(KOMP)Wtsi
    ovary, HET, Female, WTSI
respiratory system (2)
  • Akap9tm1a(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    lung, HET, Female, WTSI
sensory organ (2)
  • Akap9tm1a(KOMP)Wtsi
    pinna, skin, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    eye, HET, Female, WTSI
urinary system (2)
  • Akap9tm1a(KOMP)Wtsi
    lower urinary tract, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
cardiovascular system (1)
  • Akap9tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
endocrine system (1)
  • Akap9tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (137)
  • Akap9tm1a(KOMP)Wtsi
    head, WT, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    body, WT, Male, WTSI
  • Akap9tm1a(KOMP)Wtsi
    head, WT, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    forearm, WT, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    body, WT, Female, WTSI

show all 137 images

Skin Histopathology (6)
  • Akap9tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI

show all 6 images

Brain Histopathology (3)
  • Akap9tm1a(KOMP)Wtsi
    corpus callosum, HET, Male, WTSI
  • Akap9tm1a(KOMP)Wtsi
    corpus callosum, decreased corpus callosum size, HET, Male, WTSI
  • Akap9tm1a(KOMP)Wtsi
    decreased corpus callosum size, corpus callosum, HET, Male, WTSI
Eye Morphology (2)
  • Akap9tm1a(KOMP)Wtsi
    eye, abnormal retinal blood vessel pattern, HOM, Female, WTSI
  • Akap9tm1a(KOMP)Wtsi
    eye, abnormal retinal blood vessel pattern, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Akap9tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Akap9tm292971(L1L2_Bact_P)
Vector
Gene
Akap9tm37213(L1L2_Bact_P)
Vector
Gene