Gene: Rxfp2

Order

Name relaxin/insulin-like family peptide receptor 2

Synonyms
  • LGR8
  • Great
  • Gpr106

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2153463    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Rxfp2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Rxfp2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal liver morphology Rxfp2tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
male infertility Rxfp2tm1b(EUCOMM)Wtsi HOM Male postpartum stage 0.0
small testis Rxfp2tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
urinary bladder obstruction Rxfp2tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
abnormal lens morphology Rxfp2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 2.04E-9
increased circulating alkaline phosphatase level Rxfp2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.26E-7
decreased IgE level Rxfp2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.59E-6
increased circulating sodium level Rxfp2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 4.89E-6
abnormal optic disk morphology Rxfp2tm1b(EUCOMM)Wtsi HOM Male postnatal 8.52E-6
increased circulating calcium level Rxfp2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.27E-5
abnormal behavior Rxfp2tm1a(EUCOMM)Wtsi HOM Female postnatal 1.92E-5
decreased body weight Rxfp2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.22E-5
hypoactivity Rxfp2tm1a(EUCOMM)Wtsi HOM Male postnatal 6.45E-5
increased circulating chloride level Rxfp2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 8.14E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 1 No (5/393)
Aorta 1 No (1/562)
Blood 1 No
Bone 1 No (1/539)
Bone marrow 1 No
Brain 1 No (6/562)
Brainstem 1 No (4/562)
Brown adipose tissue 1 No
Cartilage tissue 1 No (1/562)
Cecum 1 No (1/355)
Cerebellum 1 No (4/562)
Cerebral cortex 1 No (5/562)
Chest bone 1 No
Colon 1 No (1/99)
Cranium 1 No
Diaphragm 1 No
Epididymis 1 No (4/106)
Esophagus 1 No (2/393)
Eye 1 No (1/562)
Gall bladder 1 No
Harderian gland 1 No
Heart 1 No (3/562)
Hindlimb 1 No
Hippocampus 1 No (5/562)
Hypothalamus 1 No (4/562)
Kidney 1 No (20/562)
Large intestine 1 No (12/562)
Liver 1 No
Lower urinary tract 1 No (3/562)
Lung 1 No (3/562)
Lymph node 1 No (1/562)
Main olfactory bulb 1 No
Mammary gland 1 No
Mesenteric lymph node 1 No
Olfactory lobe 1 No (4/393)
Oral epithelium 1 No
Ovary 1 No (1/562)
Oviduct 1 No (2/562)
Pancreas 1 No (6/562)
Parathyroid gland 1 No (2/540)
Parotid gland 1 No
Penis 1 No
Peripheral nervous system 1 No (3/562)
Peyer's patch 1 No (1/393)
Pituitary gland 1 No (1/562)
Prostate gland 1 No (5/562)
Sciatic nerve 1 No
Skeletal muscle 1 No
Skin 1 No (1/562)
Small intestine 1 No (11/562)
Spinal cord 1 No (3/562)
Spleen 1 No (4/562)
Stomach 1 No (9/562)
Stomach pyloric region 1 No
Striatum 1 No (4/562)
Sublingual gland 1 No
Submandibular gland 1 No (1/104)
Testis 1 No (4/562) (1/1)
Thymus 1 No
Thyroid gland 1 No (16/562)
Tongue 1 No
Trachea 1 No (3/562)
Trigeminal V nerve 1 No
Urinary bladder 1 No
Uterus 1 No (2/562)
Vagina 1 No
Vas deferens 1 No (1/360)
Vascular system 1 No (1/393)
Vesicular gland 1 No
White adipose tissue 1 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    reproductive system
    trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    9 Images
  • X-ray: XRay Images Lateral Orientation
    9 Images
  • Adult LacZ: LacZ Images Wholemount
    1 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Rxfp2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Rxfp2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Rxfp2tm39993(L1L2_st1)
Vector
Gene