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Gene: Creld1 MGI:2152539

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cysteine-rich with EGF-like domains 1
Synonyms:
N/A

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Creld1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Creld1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Atrioventricular Septal Defect, Susceptibility To, 2
Atrioventricular canal defect, Dextrocardia OMIM:606217

The table below shows human diseases predicted to be associated to Creld1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Atrioventricular Septal Defect, Susceptibility To, 2
Atrioventricular canal defect, Dextrocardia OMIM:606217

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Creld1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Creld1.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Creld1 regulates myocardial development and function. Journal of molecular and cellular cardiology (March 2021) Creld1tm1c(EUCOMM)Wtsi Creld1tm1a(EUCOMM)Wtsi 33773996
Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling. Developmental cell (March 2014) Creld1tm1a(EUCOMM)Wtsi Creld1tm1(KOMP)Vlcg 24697899

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Creld1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Creld1tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Creld1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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