Gene: Dbn1

Order

Name drebrin 1

Synonyms
  • drebrin A
  • drebrin E2

Status ES CellsMice
tm1a
Mice
tm1b
Mice
em1
Mice
em2
Mice
em1
phenotype data available

Links MGI:1931838    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Lethal     Homozygous - Subviable

Phenotype associations for Dbn1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dbn1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal allantois morphology Dbn1em2(IMPC)Mbp HOM Female Male embryonic day 9.5 0.0
abnormal chorioallantoic fusion Dbn1em2(IMPC)Mbp HOM Female Male embryonic day 9.5 0.0
abnormal embryo size Dbn1tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal embryo size Dbn1em2(IMPC)Mbp HOM Female Male embryonic day 9.5 0.0
abnormal embryo turning Dbn1em2(IMPC)Mbp HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Dbn1em2(IMPC)Mbp HOM Female Male embryonic day 12.5 0.0
enlarged heart Dbn1tm1b(KOMP)Wtsi HET Male postnatal 0.0
increased CD8-positive, alpha-beta T cell number Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 0.0
pallor Dbn1em2(IMPC)Mbp HET Female Male embryonic day 9.5 0.0
preweaning lethality, complete penetrance Dbn1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
preweaning lethality, incomplete penetrance Dbn1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
preweaning lethality, incomplete penetrance Dbn1tm1a(KOMP)Wtsi HOM Female Male n/a 0.0
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 6.22E-23
decreased body weight Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 2.54E-16
decreased circulating HDL cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 2.04E-15
decreased circulating serum albumin level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 2.52E-12
decreased circulating cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 3.63E-11
increased fluid intake Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 2.18E-9
increased heart weight Dbn1tm1b(KOMP)Wtsi HET Male postnatal 7.23E-8
increased circulating chloride level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 8.94E-8
decreased total body fat amount Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 1.15E-7
decreased circulating total protein level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 1.35E-7
decreased circulating LDL cholesterol level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 8.61E-7
decreased total retina thickness Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 1.27E-6
abnormal retinal inner nuclear layer morphology Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 1.72E-6
abnormal sleep behavior Dbn1tm1b(KOMP)Wtsi HET Male postnatal 2.67E-6
decreased circulating calcium level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 6.19E-6
abnormal coat appearance Dbn1em1(IMPC)Bay HOM Male postnatal 7.23E-6
increased lean body mass Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 1.53E-5
decreased circulating aspartate transaminase level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 1.65E-5
decreased mean corpuscular volume Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 1.74E-5
increased lean body mass Dbn1tm1a(KOMP)Wtsi HET Female Male postnatal 2.29E-5
abnormal vertebrae morphology Dbn1tm1b(KOMP)Wtsi HET Male postnatal 2.52E-5
thrombocytosis Dbn1tm1a(KOMP)Wtsi HOM Male postnatal 3.42E-5
decreased total body fat amount Dbn1tm1a(KOMP)Wtsi HET Female Male postnatal 3.56E-5
decreased mean platelet volume Dbn1tm1b(KOMP)Wtsi HET Female postnatal 3.58E-5
decreased circulating fructosamine level Dbn1tm1a(KOMP)Wtsi HOM Male postnatal 4.05E-5
increased circulating phosphate level Dbn1tm1b(KOMP)Wtsi HET Male postnatal 4.66E-5
decreased circulating alanine transaminase level Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 4.7E-5
improved glucose tolerance Dbn1tm1b(KOMP)Wtsi HET Male postnatal 5.1E-5
increased food intake Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 5.39E-5
increased circulating creatinine level Dbn1tm1b(KOMP)Wtsi HET Female Male postnatal 6.56E-5
decreased monocyte cell number Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 7.53E-5
decreased effector memory CD8-positive, alpha-beta T cell number Dbn1tm1a(KOMP)Wtsi HOM Female Male postnatal 8.78E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/4)
Adrenal gland 18 No (2/415) (9/18)
Aorta 22 No (6/22)
Blood 6 No
Blood vessel 4 No (1/4)
Bone 15 No (4/15)
Bone marrow 6 No
Brain 22 No (20/22)
Brainstem 22 No (14/22)
Brown adipose tissue 4 No
Brown adipose tissue 16 No
Cartilage tissue 22 No
Cecum 12 No (12/383) (7/12)
Cerebellum 22 No (18/22)
Cerebral cortex 22 No (14/22)
Chest bone 10 No
Colon 10 No (12/127) (8/10)
Cranium 6 No
Diaphragm 10 No
Duodenum 8 No (2/127) (8/8)
Epididymis 12 No (18/134) (3/12)
Esophagus 18 No (7/415) (5/18)
Eye 22 No (9/22)
Gall bladder 18 No
Gonadal fat pad 8 No
Harderian gland 10 No
Heart 22 No
Hindlimb 10 No
Hippocampus 22 No (14/22)
Hypothalamus 22 No (14/22)
Ileum 8 No (14/127) (7/8)
Jejunum 8 No (6/127) (6/8)
Kidney 22 No (18/584) (16/22)
Large intestine 22 No (10/584) (16/22)
Liver 22 No
Lower urinary tract 22 No (5/22)
Lung 22 No
Lymph node 22 No
Main olfactory bulb 6 No (4/6)
Mammary gland 22 No (1/22)
Mesenteric lymph node 12 No
Mesenteric adipose tissue 8 No
Midbrain 10 No (10/10)
Esophagus 4 No
Olfactory lobe 18 No (15/18)
Olfactory lobe 4 No (2/4)
Oral epithelium 10 No
Ovary 22 No (1/584) (6/22)
Oviduct 22 No (7/22)
Pancreas 22 No (5/584) (2/22)
Parathyroid gland 18 No (1/18)
Parotid gland 10 No
Penis 10 No (3/10)
Peripheral nervous system 22 No (15/22)
Peyer's patch 4 No
Peyer's patch 18 No
Pituitary gland 22 No (15/22)
Prostate gland 22 No (12/584) (3/22)
Quadriceps 8 No (1/8)
Sciatic nerve 10 No (3/10)
Skeletal muscle 18 No
Skeletal muscle tissue 4 No
Skin 22 No (3/22)
Small intestine 22 No (9/584) (14/22)
Spinal cord 22 No (22/22)
Spleen 22 No (2/584)
Stomach 22 No (12/584) (12/22)
Stomach pyloric region 10 No
Striatum 22 No (14/22)
Sublingual gland 10 No (2/10)
Submandibular gland 12 No (2/132) (1/12)
Testis 22 No (2/584) (9/22)
Thalamus 6 No (6/6)
Thymus 22 No
Thyroid gland 22 No (15/584) (4/22)
Tongue 10 No (5/127) (4/10)
Trachea 22 No
Trigeminal V nerve 12 No (8/12)
Urinary bladder 14 No (4/14)
Uterus 22 No (8/22)
Vagina 10 No
Vas deferens 12 No (15/388) (2/12)
Vascular system 18 No (2/18)
Vesicular gland 12 No (1/12)
White adipose tissue 22 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    limb
    digestive system
    cardiovascular system
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • limb(4)
    Sciatic nerve expression
    MA:0001172

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 7 (1/47) (10/11)
Axial skeleton 7 (1/51) (10/11)
Brain 16 (6/485) (20/23)
Central nervous system ganglion 3 (1/51) (3/4)
Cranium 2 (1/46) (2/3)
Dorsal root ganglion 3 (1/47) (2/4)
Ear 16 (1/485) (18/23)
Embryo 16 (1/485) (21/23)
Outer ear 2 (1/47) (2/3)
Eye 16 (1/485) (21/23)
Femur pre-cartilage condensation 2 (1/46) (2/3)
Foot 16 (1/485) (10/23)
Forearm 6 (1/282) (6/7)
Forebrain 16 (1/485) (20/23)
Forelimb 16 (1/485) (21/23)
Fronto-nasal process 7 (1/48) (9/11)
Gut 3 (1/50) (3/4)
Hand 16 (1/485) (10/23)
Head 16 (5/485) (21/23)
Head mesenchyme 7 (1/47) (9/10)
Heart 16 (1/485) (13/23)
Heart ventricle 7 (1/47) (10/11)
Hindbrain 16 (6/485) (20/23)
Hindlimb 16 (1/485) (21/23)
Humerus pre-cartilage condensation 2 (1/46) (2/3)
Inner ear 2 (1/46) (2/3)
Intestine 2 (1/47) (2/3)
Liver 16 (1/485) (5/23)
Lower leg 6 (1/282) (6/7)
Lung 16 (1/485) (13/23)
Mandibular process 16 (1/485) (19/23)
Maxillary process 16 (1/485) (19/23)
Meckel's cartilage 5 (8/8)
Mesonephros of female 2 (1/46) (2/3)
Mesonephros of male 2 (1/46) (2/3)
Metanephros 2 (1/46) (2/3)
Midbrain 16 (1/485) (20/23)
Nasal septum 2 (1/47) (2/3)
Nose 8 (1/51) (11/12)
Notochord 7 (1/47) (10/11)
Oral cavity 16 (1/485) (14/23)
Outflow tract 7 (1/47) (10/11)
Pancreas 2 (1/46) (2/3)
Pericardium 3 (1/46) (3/4)
Pharynx 2 (1/46) (2/3)
Radius-ulna pre-cartilage condensation 2 (1/46) (2/3)
Rib pre-cartilage condensation 2 (1/46) (2/3)
Skeleton 7 (1/51) (10/11)
Skin 16 (1/485) (15/23)
Spinal cord 6 (1/50) (8/9)
Stomach 2 (1/46) (2/3)
Tail 16 (1/485) (20/23)
Tail somite 16 (1/485) (17/23)
Thoracic vertebral cartilage condensation 2 (1/46) (2/3)
Tongue 2 (1/46) (2/3)
Trachea 3 (1/50) (3/4)
Trunk mesenchyme 7 (1/47) (9/11)
Umbilical artery embryonic part 2 (1/47) (2/3)
Umbilical vein embryonic part 2 (1/47) (2/3)
Upper arm 6 (1/282) (6/7)
Upper leg 6 (1/282) (6/7)
Urinary system 3 (1/50) (3/4)
Vibrissa 7 (1/47) (10/11)
  • alimentary system(1)
    Mandibular process expression
    Maxillary process expression
    EMAPA:17355 mandibular process
    EMAPA:17359 maxillary process
  • limb(4)
    Forelimb expression
    EMAPA:17412 forelimb
  • tail(2)
    Tail expression
    Tail somite group expression
    EMAPA:16748 tail
    EMAPA:16860 tail somite


Secondary lacZ Expression Data
postnatal mouse (22)
  • Dbn1tm1a(KOMP)Wtsi
    blood vessel, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    aorta, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    stomach, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI

show all 22 images

trunk (13)
  • Dbn1tm1a(KOMP)Wtsi
    aorta, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    stomach, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI

show all 13 images

nervous system (7)
  • Dbn1tm1a(KOMP)Wtsi
    brain, HET, Male, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    brain, HET, Male, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    peripheral nervous system, pituitary gland, HET, Female, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    spinal cord, HET, Female, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    olfactory lobe, HET, Female, WTSI

show all 7 images

digestive system (5)
  • Dbn1tm1a(KOMP)Wtsi
    stomach, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    small intestine, HET, Male, WTSI
cardiovascular system (2)
  • Dbn1tm1a(KOMP)Wtsi
    blood vessel, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    aorta, HET, Female, WTSI
endocrine system (2)
  • Dbn1tm1a(KOMP)Wtsi
    thyroid gland, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
reproductive system (2)
  • Dbn1tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    uterus, ovary, oviduct, HET, Female, WTSI
urinary system (2)
  • Dbn1tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
musculoskeletal system (1)
  • Dbn1tm1a(KOMP)Wtsi
    bone, HET, Female, WTSI
sensory organ (1)
  • Dbn1tm1b(KOMP)Wtsi
    eye, HET, Female, WTSI

Associated Images

Associated Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • Embryo LacZ: LacZ images wholemount
    79 Images
  • X-ray: XRay Images Skull Lateral Orientation
    70 Images
  • X-ray: XRay Images Dorso Ventral
    230 Images
  • X-ray: XRay Images Lateral Orientation
    191 Images
  • Gross Pathology and Tissue Collection
    9 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    95 Images
  • Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
    4 Images
  • X-ray: XRay Images Hind Leg and Hip
    31 Images
  • Sleep Wake: Wake state (bmp file)
    3 Images
Legacy Phenotype Associated Images
Xray (472)
  • Dbn1tm1a(KOMP)Wtsi
    body, WT, Male, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    body, WT, Male, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    body, WT, Male, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    head, WT, Male, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    body, HOM, Male, WTSI

show all 472 images

Brain Histopathology (13)
  • Dbn1tm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    WT, Male, WTSI

show all 13 images

Eye Morphology (6)
  • Dbn1tm1a(KOMP)Wtsi
    eye, corneal opacity, HOM, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    eye, eyelids fail to open, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    eye, abnormal pupil morphology, fused cornea and lens, corneal opacity, corneal vascularization, impaired pupillary reflex, abnormal placement of pupils, HET, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    eye, persistence of hyaloid vascular system, HOM, Female, WTSI
  • Dbn1tm1a(KOMP)Wtsi
    eye, persistence of hyaloid vascular system, abnormal retinal pigmentation, HOM, Female, WTSI

show all 6 images

Histology Slide (6)
  • Dbn1tm1b(KOMP)Wtsi
    TS20 head, HET, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    TS20 mandibular process, HET, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    TS20 eye, HET, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    TS20 brain, HET, Male, WTSI
  • Dbn1tm1b(KOMP)Wtsi
    TS20 skin, HET, Male, WTSI

show all 6 images

Skin Histopathology (1)
  • Dbn1tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dbn1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dbn1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Dbn1em1(IMPC)Bay Exon Deletion
Vector
Gene
Dbn1em2(IMPC)Mbp Null reporter
Vector
Gene
Fixed Tissue
Dbn1em1(IMPC)J Intra-exdel deletion
Vector
Gene