Gene: Mtor

Order

Name mechanistic target of rapamycin kinase

Synonyms
  • mechanistic target of rapamycin (serine/threonine kinase)
  • flat
  • FKBP-rapamycin-associated protein FRAP
  • Frap1
  • RAPT1
  • RAFT1
  • 2610315D21Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1928394    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Mtor

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mtor data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Mtortm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased mean corpuscular hemoglobin Mtortm1a(EUCOMM)Wtsi HET Female Male postnatal 3.82E-6
decreased blood urea nitrogen level Mtortm1a(EUCOMM)Wtsi HET Female Male postnatal 8.22E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No
Blood vessel 2 No (2/2)
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (2/2)
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No (1/2)
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No (1/2)
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No (2/2)
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system immune system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (28)
  • Mtortm1a(EUCOMM)Wtsi
    small intestine, peyer's patch, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    mesenteric lymph node, lymph node, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    skin, skin muscle, HET, Female, WTSI

show all 28 images

trunk (16)
  • Mtortm1a(EUCOMM)Wtsi
    small intestine, peyer's patch, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI

show all 16 images

digestive system (4)
  • Mtortm1a(EUCOMM)Wtsi
    small intestine, peyer's patch, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    stomach, oesophagus, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    liver, gall bladder, HET, Female, WTSI
immune system (4)
  • Mtortm1a(EUCOMM)Wtsi
    small intestine, peyer's patch, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    mesenteric lymph node, lymph node, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
nervous system (4)
  • Mtortm1a(EUCOMM)Wtsi
    pituitary gland, peripheral nervous system, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
adipose tissue (3)
  • Mtortm1a(EUCOMM)Wtsi
    brown adipose tissue, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    inguinal fat pad, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI
integumental system (3)
  • Mtortm1a(EUCOMM)Wtsi
    skin, skin muscle, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    skin, tail, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    skin, pinna, HET, Female, WTSI
set of connective tissues (3)
  • Mtortm1a(EUCOMM)Wtsi
    brown adipose tissue, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    inguinal fat pad, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI
cardiovascular system (2)
  • Mtortm1a(EUCOMM)Wtsi
    skeletal muscle tissue, blood vessel, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
endocrine system (2)
  • Mtortm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    thyroid gland, trachea, parathyroid gland, HET, Female, WTSI
musculoskeletal system (2)
  • Mtortm1a(EUCOMM)Wtsi
    skeletal muscle tissue, blood vessel, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    skeletal muscle tissue, white adipose tissue, cartilage tissue, HET, Female, WTSI
reproductive system (2)
  • Mtortm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    ovary, oviduct, uterus, HET, Female, WTSI
respiratory system (2)
  • Mtortm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    thyroid gland, trachea, parathyroid gland, HET, Female, WTSI
sensory organ (2)
  • Mtortm1a(EUCOMM)Wtsi
    skin, pinna, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI
urinary system (2)
  • Mtortm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (169)
  • Mtortm1a(EUCOMM)Wtsi
    forearm, HET, Male, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    forearm, HET, Male, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    head, HET, Male, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    body, HET, Male, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    body, HET, Male, WTSI

show all 169 images

Skin Histopathology (3)
  • Mtortm1a(EUCOMM)Wtsi
    back skin, WT, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    back skin, WT, Female, WTSI
  • Mtortm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
Eye Morphology (1)
  • Mtortm1a(EUCOMM)Wtsi
    eye, abnormal cornea morphology, HET, Female, WTSI
Tail Epidermis Wholemount (1)
  • Mtortm1a(EUCOMM)Wtsi
    tail skin, WT, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mtortm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Mtortm608(L1L2_gt0_Del_LacZ)
Vector
Gene
Mtortm608(pL1L2_GT0_DelLacZ_bsd)
Vector
Gene