Gene: Crispld2

Order

Name cysteine-rich secretory protein LCCL domain containing 2

Synonyms
  • coffeecrisp
  • 1810049K24Rik
  • Lgl1

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1926142    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Crispld2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Crispld2 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Crispld2tm1.1(KOMP)Vlcg HOM Male embryonic day 15.5 0.0
abnormal heart morphology Crispld2tm1.1(KOMP)Vlcg HOM Male embryonic day 15.5 0.0
prenatal lethality prior to heart atrial septation Crispld2tm1.1(KOMP)Vlcg HOM Female Male embryonic day 14.5 0.0
preweaning lethality, complete penetrance Crispld2tm1.1(KOMP)Vlcg HOM Female Male n/a 0.0
increased circulating alanine transaminase level Crispld2tm1.1(KOMP)Vlcg HET Male postnatal 8.01E-7
decreased circulating triglyceride level Crispld2tm1.1(KOMP)Vlcg HET Male postnatal 9.54E-6
decreased bone mineral density Crispld2tm1.1(KOMP)Vlcg HET Male postnatal 9.54E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Bone 1 No (1/1)
Brain 2 No (1/2)
Brainstem 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Esophagus 2 No (7/415) (2/2)
Eye 2 No
Heart 2 No (1/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Testis 2 No (2/584)
Thymus 2 No
Thyroid gland 2 No (15/584) (1/2)
Tongue 1 No (5/127) (1/1)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    digestive system
    cardiovascular system
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 0 (1/51)
Brain 0 (6/485)
Central nervous system ganglion 0 (1/51) (1/1)
Ear 0 (1/485)
Embryo 0 (1/485) (1/1)
Eye 0 (1/485) (1/1)
Foot 0 (1/485) (1/1)
Forebrain 0 (1/485)
Forelimb 0 (1/485) (1/1)
Gut 0 (1/50) (1/1)
Hand 0 (1/485)
Head 0 (5/485)
Heart 0 (1/485)
Hindbrain 0 (6/485)
Hindlimb 0 (1/485) (1/1)
Liver 0 (1/485) (1/1)
Lung 0 (1/485)
Mandibular process 0 (1/485)
Maxillary process 0 (1/485)
Midbrain 0 (1/485)
Nose 0 (1/51) (1/1)
Oral cavity 0 (1/485)
Skeleton 0 (1/51)
Skin 0 (1/485)
Spinal cord 0 (1/50)
Tail 0 (1/485)
Tail somite 0 (1/485) (1/1)
Trachea 0 (1/50) (1/1)
Urinary system 0 (1/50) (1/1)


Associated Images

Associated Images
  • Gross Morphology Embryo E9.5
    1 Images
  • Eye Morphology: Images Ophthalmoscopy
    7 Images
  • Eye Morphology: Images Slit Lamp
    2 Images
  • Adult LacZ: LacZ Images Section
    16 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    11 Images
  • X-ray: XRay Images Dorso Ventral
    11 Images
  • X-ray: XRay Images Skull Lateral Orientation
    11 Images
  • Gross Pathology and Tissue Collection
    8 Images
  • X-ray: XRay Images Lateral Orientation
    11 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Crispld2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Crispld2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Crispld2tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Crispld2tm43718(L1L2_st0)
Vector
Gene