Gene: Sorbs2

Order

Name sorbin and SH3 domain containing 2

Synonyms
  • 2010203O03Rik
  • 9430041O17Rik

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1924574    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Sorbs2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Sorbs2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
shortened PQ interval Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 4.18E-8
hypoactivity Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 1.7E-7
shortened PR interval Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 4.11E-7
decreased vertical activity Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 2.53E-6
decreased circulating glucose level Sorbs2tm1.1(KOMP)Mbp HOM Male postnatal 3.61E-6
decreased circulating HDL cholesterol level Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 1.95E-5
increased heart rate Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 3.42E-5
shortened ST segment Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 4.97E-5
decreased circulating cholesterol level Sorbs2tm1.1(KOMP)Mbp HOM Female Male postnatal 5.45E-5
decreased circulating free fatty acid level Sorbs2tm1.1(KOMP)Mbp HOM Male postnatal 5.46E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No (2/2)
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Epididymis 2 No (18/134)
Esophagus 2 No (7/415)
Eye 2 No
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No
Uterus 2 No
Vascular system 2 No (2/2)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system digestive system cardiovascular system nervous system reproductive system exocrine system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/3)
Dorsal root ganglion 2 (1/47) Image Only
Ear 2 (1/485)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485) (2/3)
Forelimb 2 (1/485)
Fronto-nasal process 2 (1/48)
Hand 2 (1/485)
Head 2 (5/485) (2/3)
Heart 2 (1/485) (2/3)
Hindbrain 2 (6/485) (2/3)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485) Image Only
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485) (2/3)
Nose 2 (1/51)
Oral cavity 2 (1/485)
Skin 2 (1/485) Image Only
Spinal cord 2 (1/50) (2/3)
Tail 2 (1/485) (2/3)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    9 Images
  • X-ray: XRay Images Dorso Ventral
    9 Images
  • X-ray: XRay Images Skull Lateral Orientation
    9 Images
  • Sleep Wake: Wake state (bmp file)
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    9 Images
  • X-ray: XRay Images Lateral Orientation
    9 Images
  • Combined SHIRPA and Dysmorphology
    10 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Sorbs2tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Sorbs2tm1.1(KOMP)Mbp Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Sorbs2tm443565(L1L2_Bact_P)
Vector
Gene