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Gene: Gns MGI:1922862

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
glucosamine (N-acetyl)-6-sulfatase
Synonyms:
G6S,  2610016K11Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gns mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Gns by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Mucopolysaccharidosis, Type Iiid
Splenomegaly, Difficulty walking OMIM:252940

The table below shows human diseases predicted to be associated to Gns by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Focal Cortical Dysplasia, Type Ii
Astrocytosis OMIM:607341
Familial Infantile Bilateral Striatal Necrosis
Ataxia, Gait ataxia, Choreoathetosis, Astrocytosis, Gait disturbance, Loss of ambulation, Basal g... ORPHA:225154
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Gait disturbance, Astrocytosis OMIM:600795
Sporadic Creutzfeldt-Jakob Disease
Gliosis, Ataxia, Astrocytosis ORPHA:204
Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
Inability to walk, Difficulty walking, Astrocytosis OMIM:611087
Behavioral Variant Of Frontotemporal Dementia
Gait disturbance, Astrocytosis ORPHA:275864
Inherited Creutzfeldt-Jakob Disease
Gait ataxia, Progressive cerebellar ataxia, Bradykinesia, Astrocytosis ORPHA:282166
Fanconi Anemia, Complementation Group G
Abnormality of chromosome stability, Anemia, Neutropenia, Leukemia, Thrombocytopenia OMIM:614082
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Splenomegaly, Astrocytosis, Bradykinesia, Dysdiadochokinesis, Gait disturbance, Difficulty walkin... ORPHA:309854
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Supranuclear Palsy, Progressive, 1
Akinesia, Astrocytosis, Bradykinesia, Gliosis, Gait imbalance, Falls OMIM:601104
Transcobalamin Deficiency
Abnormality of chromosome stability, Pancytopenia, Neutropenia, Lymphopenia, Thrombocytopenia ORPHA:859
Progressive Non-Fluent Aphasia
Astrocytosis ORPHA:100070
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Inability to walk, Astrocytosis ORPHA:258
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Gliosis, Ataxia, Astrocytosis OMIM:203700
Cockayne Syndrome Type 3
Splenomegaly, Unsteady gait, Difficulty walking, Astrocytosis ORPHA:90324
Mucopolysaccharidosis, Type Iiid
Splenomegaly, Difficulty walking OMIM:252940

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gns

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gns.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Disease correction by AAV-mediated gene therapy in a new mouse model of mucopolysaccharidosis type IIID. Human molecular genetics (April 2017) Gnstm1e(EUCOMM)Hmgu 28334745

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Gnstm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gnstm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Gnstm3e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Gnstm3a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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