Gene: Plekhm2

Order

Name pleckstrin homology domain containing, family M (with RUN domain) member 2

Synonyms 2310034J19Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1916832    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Plekhm2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Plekhm2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased hemoglobin content Plekhm2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.29E-8
increased leukocyte cell number Plekhm2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.93E-8
decreased body weight Plekhm2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 5.1E-6
increased CD8-positive, alpha-beta T cell number Plekhm2tm1a(EUCOMM)Wtsi HOM Female postnatal 7.21E-6
decreased hematocrit Plekhm2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 7.36E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No
Blood vessel 2 No (2/2)
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No (2/2)
Mammary gland 2 No (2/2)
Esophagus 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No (1/2)
Pituitary gland 2 No (1/2)
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle tissue 2 No (2/2)
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
White adipose tissue 2 No (1/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (27)
  • Plekhm2tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    lymph node, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, blood vessel, cartilage tissue, bone, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    mammary gland, white adipose tissue, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI

show all 27 images

trunk (17)
  • Plekhm2tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    uterus, oviduct, ovary, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    thyroid gland, trachea, parathyroid gland, HET, Female, WTSI

show all 17 images

digestive system (4)
  • Plekhm2tm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    small intestine, peyer's patch, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    gall bladder, HET, Female, WTSI
immune system (4)
  • Plekhm2tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    lymph node, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    spleen, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    small intestine, peyer's patch, HET, Female, WTSI
nervous system (4)
  • Plekhm2tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    peripheral nervous system, pituitary gland, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    spinal cord, HET, Male, WTSI
set of connective tissues (3)
  • Plekhm2tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, blood vessel, cartilage tissue, bone, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    mammary gland, white adipose tissue, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, cartilage tissue, bone, HET, Female, WTSI
urinary system (3)
  • Plekhm2tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    lower urinary tract, urinary bladder, HET, Male, WTSI
cardiovascular system (2)
  • Plekhm2tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, blood vessel, cartilage tissue, bone, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
endocrine system (2)
  • Plekhm2tm1a(EUCOMM)Wtsi
    thyroid gland, trachea, parathyroid gland, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
integumental system (2)
  • Plekhm2tm1a(EUCOMM)Wtsi
    mammary gland, white adipose tissue, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    skin, HET, Female, WTSI
musculoskeletal system (2)
  • Plekhm2tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, blood vessel, cartilage tissue, bone, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    skeletal muscle tissue, cartilage tissue, bone, HET, Female, WTSI
reproductive system (2)
  • Plekhm2tm1a(EUCOMM)Wtsi
    uterus, oviduct, ovary, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
respiratory system (2)
  • Plekhm2tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    thyroid gland, trachea, parathyroid gland, HET, Female, WTSI
adipose tissue (1)
  • Plekhm2tm1a(EUCOMM)Wtsi
    mammary gland, white adipose tissue, HET, Female, WTSI
exocrine system (1)
  • Plekhm2tm1a(EUCOMM)Wtsi
    mammary gland, white adipose tissue, HET, Female, WTSI
sensory organ (1)
  • Plekhm2tm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (132)
  • Plekhm2tm1a(EUCOMM)Wtsi
    head, HOM, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    forearm, HOM, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    body, HOM, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    head, HOM, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    head, HOM, Female, WTSI

show all 132 images

Skin Histopathology (2)
  • Plekhm2tm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI
  • Plekhm2tm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Plekhm2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Plekhm2tm44411(L1L2_gt1_Del_LacZ)
Vector
Gene
Plekhm2tm44411(pL1L2_frt15_BetactinBSD_frt14_neo_Rox)
Vector
Gene