Gene: Cog6

Order

Name component of oligomeric golgi complex 6

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1914792    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Cog6

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cog6 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased CD4-positive NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased CD4-positive, alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased CD8-positive, alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased CD8-positive, naive alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased Ly6C-positive immature NK cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased Ly6C-positive mature NK cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased NK cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased T-helper cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased effector memory CD8-positive, alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased marginal zone B cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased memory-marker CD4-negative NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased memory-marker CD4-positive NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased memory-marker NK cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased memory-marker gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased transitional stage T2 B cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased B-2 B cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased CD4-negative NK T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased CD4-positive, alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased CD5-positive gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased KLRG1+ CD8 alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased KLRG1-positive NK cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased KLRG1-positive T-helper cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased effector memory T-helper cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased eosinophil cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased follicular B cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased granulocyte number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased memory-marker NK cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased memory-marker gamma-delta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased monocyte cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased plasma cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased red blood cell distribution width Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.98E-10
vertebral transformation Cog6tm1a(EUCOMM)Wtsi HOM Male postnatal 3.17E-10
increased circulating alkaline phosphatase level Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 7.06E-9
increased circulating amylase level Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.38E-7
decreased hemoglobin content Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 3.97E-7
increased mean platelet volume Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 9.9E-7
abnormal coat/hair pigmentation Cog6tm1a(EUCOMM)Wtsi HOM Female postnatal 2.65E-5
decreased bone mineral content Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.96E-5
abnormal cornea morphology Cog6tm1a(EUCOMM)Wtsi HOM Female postnatal 3.53E-5
decreased erythrocyte cell number Cog6tm1a(EUCOMM)Wtsi HOM Male postnatal 3.91E-5
increased circulating total protein level Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.01E-5
increased effector memory CD4-positive, alpha-beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 5.41E-5
increased KLRG1+ CD4 alpha beta T cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 5.71E-5
increased Ly6C high monocyte number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 5.71E-5
increased B cell number Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 6.35E-5
abnormal bone structure Cog6tm1a(EUCOMM)Wtsi HOM Female Male postnatal 8.54E-5

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    27 Images
  • X-ray: XRay Images Forepaw
    15 Images
  • X-ray: XRay Images Dorso Ventral
    41 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
  • Eye Morphology: Images Slit Lamp
    7 Images
  • Eye Morphology: Images Ophthalmoscopy
    2 Images
  • Anti-nuclear antibody assay
    14 Images
  • DSS Histology
    16 Images
  • Ear epidermis immunophenotyping
    12 Images
Legacy Phenotype Associated Images
Xray (68)
  • Cog6tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    HOM, Female, WTSI

show all 68 images

Eye Morphology (9)
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal cornea morphology, HOM, Male, WTSI

show all 9 images

Dysmorphology (6)
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal coat/hair pigmentation, HOM, Male, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal coat/hair pigmentation, HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal tail morphology, kinked tail, HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal coat/hair pigmentation, HOM, Female, WTSI
  • Cog6tm1a(EUCOMM)Wtsi
    abnormal tail morphology, kinked tail, HOM, Female, WTSI

show all 6 images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cog6tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Cog6tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene