Gene: Mkrn2

Order

Name makorin, ring finger protein, 2

Synonyms 2610002L04Rik

Status ES CellsMice
tm1a
Mice
em1
Mice
tm1b
phenotype data available

Links MGI:1914277    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Mkrn2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mkrn2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased dendritic epidermal T cell number Mkrn2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
increased or absent threshold for auditory brainstem response Mkrn2tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
male infertility Mkrn2tm1b(KOMP)Wtsi HOM Male postpartum stage 0.0
male infertility Mkrn2em1(IMPC)Wtsi HOM Male postpartum stage 0.0
decreased lean body mass Mkrn2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.37E-5
increased eosinophil cell number Mkrn2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.26E-5
increased effector memory CD4-positive, alpha-beta T cell number Mkrn2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.58E-5
decreased body length Mkrn2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.59E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/2)
Aorta 2 No (2/2)
Blood vessel 2 No (2/2)
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Eye 2 No (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system sensory organ integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (21)
  • Mkrn2tm1b(KOMP)Wtsi
    inguinal fat pad, white adipose tissue, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    olfactory lobe, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    lower urinary tract, urinary bladder, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    gall bladder, HET, Female, WTSI

show all 21 images

trunk (15)
  • Mkrn2tm1b(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    lower urinary tract, urinary bladder, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    gall bladder, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    oviduct, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI

show all 15 images

digestive system (4)
  • Mkrn2tm1b(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    gall bladder, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    small intestine, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    large intestine, HET, Female, WTSI
nervous system (3)
  • Mkrn2tm1b(KOMP)Wtsi
    olfactory lobe, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    spinal cord, HET, Male, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    peripheral nervous system, trigeminal V nerve, HET, Female, WTSI
set of connective tissues (3)
  • Mkrn2tm1b(KOMP)Wtsi
    inguinal fat pad, white adipose tissue, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    rib, cartilage tissue, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    brown adipose tissue, HET, Female, WTSI
adipose tissue (2)
  • Mkrn2tm1b(KOMP)Wtsi
    inguinal fat pad, white adipose tissue, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    brown adipose tissue, HET, Female, WTSI
reproductive system (2)
  • Mkrn2tm1b(KOMP)Wtsi
    oviduct, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
respiratory system (2)
  • Mkrn2tm1b(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    lung, HET, Female, WTSI
urinary system (2)
  • Mkrn2tm1b(KOMP)Wtsi
    lower urinary tract, urinary bladder, HET, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI
cardiovascular system (1)
  • Mkrn2tm1b(KOMP)Wtsi
    heart, HET, Female, WTSI
endocrine system (1)
  • Mkrn2tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
integumental system (1)
  • Mkrn2tm1b(KOMP)Wtsi
    skin, HET, Male, WTSI
musculoskeletal system (1)
  • Mkrn2tm1b(KOMP)Wtsi
    rib, cartilage tissue, HET, Female, WTSI
sensory organ (1)
  • Mkrn2tm1b(KOMP)Wtsi
    eye, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    86 Images
  • X-ray: XRay Images Lateral Orientation
    56 Images
  • X-ray: XRay Images Skull Lateral Orientation
    28 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    30 Images
  • X-ray: XRay Images Forepaw
    28 Images
  • Eye Morphology: Images Slit Lamp
    4 Images
  • Anti-nuclear antibody assay
    9 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (177)
  • Mkrn2tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    WT, Female, WTSI

show all 177 images

Eye Morphology (4)
  • Mkrn2tm1b(KOMP)Wtsi
    mydriasis, HOM, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    corneal vascularization, HOM, Female, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    corneal opacity, HOM, Female, WTSI
  • Mkrn2em1(IMPC)Wtsi
    eye discharge, HOM, Female, WTSI
Histology Slide (4)
  • Mkrn2tm1b(KOMP)Wtsi
    TS20 heart, HET, Male, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    TS20 oral cavity, HET, Male, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    TS20 head, HET, Male, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    TS20 chorioallantoic placenta, HET, Male, WTSI
Dysmorphology (2)
  • Mkrn2em1(IMPC)Wtsi
    abnormal snout morphology, short snout, head, HOM, Male, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    head, abnormal snout morphology, HOM, Female, WTSI
Embryo Dysmorphology (2)
  • Mkrn2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Mkrn2tm1b(KOMP)Wtsi
    fetal edema, hemorrhage, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mkrn2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Mkrn2em1(IMPC)Wtsi Exdel
Vector
Gene
Mkrn2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene