Gene: Dnase1l2

Order

Name deoxyribonuclease 1-like 2

Synonyms 4733401H14Rik

Status ES CellsMice
tm1
Mice
tm1.1
Mice
em2
Mice
em1
Mice
em1
Mice
tm1b
phenotype data available

Links MGI:1913955    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Dnase1l2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dnase1l2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal eye morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 0.0
abnormal heart morphology Dnase1l2em2(IMPC)Mbp HOM Male postnatal 0.0
abnormal spleen morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 0.0
abnormal spleen morphology Dnase1l2em1(IMPC)Bay HOM Female Male postnatal 0.0
abnormal stomach morphology Dnase1l2tm1.1(KOMP)Wtsi HET Male postnatal 0.0
enlarged heart Dnase1l2em2(IMPC)Mbp HOM Male postnatal 0.0
hydrometra Dnase1l2em2(IMPC)Mbp HOM Female postnatal 0.0
small superior vagus ganglion Dnase1l2em2(IMPC)Mbp HOM Female postnatal 0.0
decreased grip strength Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 4.1E-29
decreased bone mineral content Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.41E-20
abnormal digit morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 5.99E-19
decreased body length Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 7.04E-19
decreased lean body mass Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.1E-14
abnormal joint morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 4.88E-14
abnormal autopod morphology Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 3.21E-13
abnormal digit morphology Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 3.21E-13
abnormal digit morphology Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.11E-12
abnormal tail morphology Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 2.24E-12
abnormal tibia morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 2.13E-11
decreased total body fat amount Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 7.02E-11
abnormal tail length Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 7.98E-11
abnormal joint morphology Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.2E-10
abnormal vertebrae morphology Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.2E-10
brachydactyly Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.2E-10
abnormal lens morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.23E-10
decreased grip strength Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 1.37E-9
scoliosis Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 4.94E-9
abnormal tail morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.12E-8
brachydactyly Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 1.18E-8
abnormal bone structure Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 2.25E-8
short tibia Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 4.33E-8
decreased bone mineral density Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 5.19E-8
abnormal nail morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female postnatal 6.68E-8
brachydactyly Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.76E-7
increased fasted circulating glucose level Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.81E-7
hypoactivity Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 2.19E-7
decreased food intake Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 2.32E-7
fusion of vertebral arches Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 2.42E-7
abnormal behavior Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 2.42E-7
decreased lean body mass Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 6.46E-7
decreased startle reflex Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 9.78E-7
abnormal cranium morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.38E-6
decreased circulating HDL cholesterol level Dnase1l2tm1(KOMP)Wtsi HOM Male postnatal 1.38E-6
vertebral fusion Dnase1l2tm1.1(KOMP)Wtsi HOM Female postnatal 1.97E-6
decreased body length Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 2.12E-6
abnormal maxilla morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 2.41E-6
abnormal head morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 2.96E-6
abnormal heart left ventricle morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 5.46E-6
decreased lean body mass Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 9.22E-6
abnormal vocalization Dnase1l2tm1.1(KOMP)Wtsi HOM Female postnatal 9.24E-6
decreased total body fat amount Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 1.1E-5
decreased circulating insulin level Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 1.32E-5
cataract Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 1.35E-5
abnormal optic disk morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 1.35E-5
short tibia Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 1.45E-5
abnormal retinal vasculature morphology Dnase1l2tm1b(KOMP)Wtsi HOM Female postnatal 1.57E-5
decreased bone mineral content Dnase1l2em1(IMPC)Bay HOM Male postnatal 1.78E-5
increased bone mineral content Dnase1l2em1(IMPC)Bay HOM Female postnatal 1.78E-5
increased grip strength Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 2.18E-5
decreased grip strength Dnase1l2tm1(KOMP)Wtsi HOM Female Male postnatal 2.38E-5
abnormal pelvic girdle bone morphology Dnase1l2tm1b(KOMP)Wtsi HOM Male postnatal 2.77E-5
increased lean body mass Dnase1l2tm1.1(KOMP)Wtsi HOM Female postnatal 3.0E-5
increased circulating amylase level Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 3.03E-5
abnormal motor capabilities/coordination/movement Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 3.27E-5
short tibia Dnase1l2tm1b(KOMP)Wtsi HOM Female postnatal 4.45E-5
increased blood urea nitrogen level Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 5.16E-5
abnormal autopod morphology Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 6.13E-5
abnormal spine curvature Dnase1l2tm1.1(KOMP)Wtsi HOM Male postnatal 6.34E-5
increased circulating HDL cholesterol level Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 8.59E-5
decreased bone mineral density Dnase1l2em1(IMPC)Bay HOM Male postnatal 8.65E-5
increased lean body mass Dnase1l2tm1b(KOMP)Wtsi HOM Female Male postnatal 8.7E-5
decreased circulating glucose level Dnase1l2tm1.1(KOMP)Wtsi HOM Female Male postnatal 9.47E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No
Adrenal gland 14 Yes (2/415)
Aorta 18 No
Blood 2 No
Blood vessel 4 No
Bone 12 Yes
Bone marrow 2 No
Brain 18 No (2/20)
Brainstem 18 No (2/20)
Brown adipose tissue 4 No
Brown adipose tissue 12 No
Cartilage tissue 18 No
Cecum 8 Yes (12/383) (1/10)
Cerebellum 18 No (2/20)
Cerebral cortex 18 No
Chest bone 6 No
Colon 6 No (12/127) (1/8)
Cranium 4 No
Diaphragm 6 No
Duodenum 6 No (2/127)
Epididymis 8 Yes (18/134) (2/10)
Esophagus 14 Yes (7/415) (2/16)
Eye 18 No
Gall bladder 14 Yes
Gonadal fat pad 6 No
Harderian gland 6 Yes
Heart 18 No
Hindlimb 6 No
Hippocampus 18 No
Hypothalamus 18 No (2/20)
Ileum 6 Yes (14/127) (1/8)
Jejunum 6 No (6/127) (1/8)
Kidney 18 Yes (18/584) (2/20)
Large intestine 18 Yes (10/584)
Liver 18 No
Lower urinary tract 18 No
Lung 18 Yes
Lymph node 18 No
Main olfactory bulb 4 No
Mammary gland 18 No
Mesenteric lymph node 6 Yes (1/8)
Mesenteric adipose tissue 6 No
Midbrain 8 No (2/10)
Esophagus 4 No
Olfactory lobe 14 No
Olfactory lobe 4 No
Oral epithelium 8 No
Ovary 18 Yes (1/584)
Oviduct 18 Yes
Pancreas 18 No (5/584)
Parathyroid gland 14 Yes
Parotid gland 6 Yes
Penis 6 No (1/8)
Peripheral nervous system 18 No
Peyer's patch 4 No
Peyer's patch 14 Yes
Pituitary gland 18 Yes
Prostate gland 18 Yes (12/584) (1/20)
Quadriceps 6 No
Sciatic nerve 6 No
Skeletal muscle 14 No
Skeletal muscle tissue 4 No
Skin 18 No (2/20)
Small intestine 18 No (9/584) (2/20)
Spinal cord 18 No
Spleen 18 Yes (2/584)
Stomach 18 Yes (12/584) (1/20)
Stomach pyloric region 6 No
Striatum 18 No
Sublingual gland 6 Yes
Submandibular gland 8 Yes (2/132) (1/10)
Testis 18 Yes (2/584) (9/20)
Thalamus 6 No (2/8)
Thymus 18 No
Thyroid gland 18 Yes (15/584) (1/20)
Tongue 6 Yes (5/127) (6/8)
Trachea 18 No (1/20)
Trigeminal V nerve 8 No
Urinary bladder 8 Yes
Uterus 18 Yes
Vagina 6 No
Vas deferens 8 No (15/388) (2/10)
Vascular system 14 No
Vesicular gland 8 Yes
White adipose tissue 18 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    endocrine system
    digestive system
    nervous system
    sensory organ
    reproductive system
    immune system
    exocrine system
    integumental system
    trunk
    urinary system

LacZ Wholemount Images

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 6 (6/485)
Dorsal root ganglion 2 (1/47)
Ear 6 (1/485)
Embryo 6 (1/485)
Eye 6 (1/485)
Foot 6 (1/485)
Forearm 2 (1/282)
Forebrain 6 (1/485)
Forelimb 6 (1/485)
Fronto-nasal process 2 (1/48)
Hand 6 (1/485)
Head 6 (5/485)
Heart 6 (1/485)
Hindbrain 6 (6/485)
Hindlimb 6 (1/485)
Liver 6 (1/485)
Lower leg 2 (1/282)
Lung 6 (1/485)
Mandibular process 6 (1/485)
Maxillary process 6 (1/485)
Midbrain 6 (1/485)
Nose 2 (1/51)
Oral cavity 6 (1/485)
Skin 6 (1/485)
Spinal cord 2 (1/50)
Tail 6 (1/485)
Tail somite 6 (1/485)
Upper arm 2 (1/282)
Upper leg 2 (1/282)


Secondary lacZ Expression Data
postnatal mouse (6)
  • Dnase1l2tm1(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    stomach, HET, Male, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Dnase1l2tm1.1(KOMP)Wtsi
    skin, HET, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    lymph node, HET, Male, WTSI

show all 6 images

trunk (4)
  • Dnase1l2tm1(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    stomach, HET, Male, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    stomach, HET, Male, WTSI
digestive system (2)
  • Dnase1l2tm1(KOMP)Wtsi
    stomach, HET, Male, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    stomach, HET, Male, WTSI
reproductive system (2)
  • Dnase1l2tm1(KOMP)Wtsi
    uterus, HET, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    testis, HET, Male, WTSI
immune system (1)
  • Dnase1l2tm1(KOMP)Wtsi
    lymph node, HET, Male, WTSI
integumental system (1)
  • Dnase1l2tm1.1(KOMP)Wtsi
    skin, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    195 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    53 Images
  • X-ray: XRay Images Lateral Orientation
    167 Images
  • X-ray: XRay Images Hind Leg and Hip
    26 Images
  • Eye Morphology: Images Ophthalmoscopy
    14 Images
  • Combined SHIRPA and Dysmorphology
    42 Images
  • X-ray: XRay Images Forepaw
    37 Images
  • Sleep Wake: Wake state (bmp file)
    22 Images
  • Electroretinography: Rod waveform (pdf format)
    1 Images
  • X-ray: XRay Images Skull Lateral Orientation
    26 Images
Legacy Phenotype Associated Images
Xray (163)
  • Dnase1l2tm1(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    forearm, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    body, HOM, Male, WTSI

show all 163 images

Dysmorphology (14)
  • Dnase1l2tm1(KOMP)Wtsi
    kinked tail, HOM, Male, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    kinked tail, abnormal tail morphology, HOM, Male, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    kinked tail, abnormal tail morphology, HOM, Male, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    kinked tail, abnormal tail morphology, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    kinked tail, abnormal tail morphology, HOM, Female, WTSI

show all 14 images

Eye Morphology (11)
  • Dnase1l2tm1(KOMP)Wtsi
    eye, persistence of hyaloid vascular system, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    eye, abnormal optic disc morphology, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    eye, abnormal retinal pigmentation, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    cornea/lens fusion, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    abnormal optic disc morphology, eye, HOM, Male, WTSI

show all 11 images

Skin Histopathology (2)
  • Dnase1l2tm1(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Dnase1l2tm1(KOMP)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dnase1l2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Dnase1l2tm1.1(KOMP)Wtsi Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue
Dnase1l2em2(IMPC)Mbp Null reporter
Vector
Gene
Fixed Tissue
Dnase1l2em1(IMPC)Bay Exon Deletion
Vector
Gene
Dnase1l2em1(IMPC)J Exon Deletion
Vector
Gene
Dnase1l2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene