Gene: Dph6

Order

Name diphthamine biosynthesis 6

Synonyms
  • 5730421E18Rik
  • Diphthine ammonia ligase
  • Atpbd4

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1913882    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Dph6

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dph6 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased CD8-positive, alpha-beta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased CD8-positive, naive alpha-beta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased Ly6C-positive mature NK cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased NK T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased T-helper cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased effector memory CD8-positive, alpha-beta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased mature B cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased CD11b-low dendritic cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased CD4-positive, alpha beta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased CD5-positive gamma-delta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased KLRG1-positive T-helper cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased Ly6C low monocyte number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased dendritic cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased effector memory CD4-positive, alpha-beta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased effector memory T-helper cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased gamma-delta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased granulocyte number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased marginal zone B cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased memory-marker CD4-negative NK T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased memory-marker gamma-delta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased monocyte cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased plasma cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
increased plasmacytoid dendritic cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
decreased erythrocyte cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 4.31E-7
increased effector memory CD8-positive, alpha-beta T cell number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 9.0E-7
vertebral transformation Dph6tm1a(KOMP)Wtsi HOM Female postnatal 9.57E-7
increased caudal vertebrae number Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 4.2E-6
decreased body length Dph6tm1a(KOMP)Wtsi HOM Male postnatal 1.41E-5
decreased hematocrit Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 1.71E-5
abnormal coat/hair pigmentation Dph6tm1a(KOMP)Wtsi HOM Female postnatal 2.65E-5
decreased hemoglobin content Dph6tm1a(KOMP)Wtsi HOM Female Male postnatal 4.19E-5

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Dorso Ventral
    45 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    17 Images
  • Eye Morphology: Images Ophthalmoscopy
    3 Images
  • Spleen Immunophenotyping: Images associated with FACS analysis
    171 Images
  • Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
    102 Images
  • DSS Histology
    8 Images
  • Anti-nuclear antibody assay
    6 Images
Legacy Phenotype Associated Images
Xray (73)
  • Dph6tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Dph6tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Dph6tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Dph6tm1a(KOMP)Wtsi
    HOM, Male, WTSI
  • Dph6tm1a(KOMP)Wtsi
    HOM, Male, WTSI

show all 73 images

Dysmorphology (4)
  • Dph6tm1a(KOMP)Wtsi
    head, abnormal snout morphology, asymmetric snout, HOM, Male, WTSI
  • Dph6tm1a(KOMP)Wtsi
    head, abnormal snout morphology, asymmetric snout, HOM, Male, WTSI
  • Dph6tm1a(KOMP)Wtsi
    abnormal coat/hair pigmentation, HOM, Female, WTSI
  • Dph6tm1a(KOMP)Wtsi
    abnormal coat/hair pigmentation, HOM, Female, WTSI
Eye Morphology (3)
  • Dph6tm1a(KOMP)Wtsi
    persistence of hyaloid vascular system, HOM, Female, WTSI
  • Dph6tm1a(KOMP)Wtsi
    persistence of hyaloid vascular system, HOM, Female, WTSI
  • Dph6tm1a(KOMP)Wtsi
    persistence of hyaloid vascular system, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dph6tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene