Gene: Lars

Order

Name leucyl-tRNA synthetase

Synonyms
  • 2310045K21Rik
  • 3110009L02Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1913808    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Lars

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Lars data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Larstm1b(KOMP)Wtsi HOM Female Male n/a 0.0
increased circulating LDL cholesterol level Larstm1b(KOMP)Wtsi HET Male postnatal 4.68E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (1)
  • Larstm1a(KOMP)Wtsi
    testis, WT, Male, WTSI
reproductive system (1)
  • Larstm1a(KOMP)Wtsi
    testis, WT, Male, WTSI
trunk (1)
  • Larstm1a(KOMP)Wtsi
    testis, WT, Male, WTSI

Associated Images

Associated Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • X-ray: XRay Images Dorso Ventral
    40 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
  • X-ray: XRay Images Lateral Orientation
    26 Images
  • X-ray: XRay Images Skull Lateral Orientation
    13 Images
  • X-ray: XRay Images Forepaw
    13 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (131)
  • Larstm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Larstm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Larstm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Larstm1b(KOMP)Wtsi
    WT, Male, WTSI
  • Larstm1b(KOMP)Wtsi
    WT, Male, WTSI

show all 131 images

Dysmorphology (2)
  • Larstm1b(KOMP)Wtsi
    abnormal tail morphology, WT, Male, WTSI
  • Larstm1b(KOMP)Wtsi
    kinked tail, abnormal tail morphology, WT, Male, WTSI
Eye Morphology (1)
  • Larstm1b(KOMP)Wtsi
    abnormal cornea morphology, HET, Male, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Larstm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Larstm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene