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Gene: Gmpr MGI:1913605

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Gene Summary

Name:
guanosine monophosphate reductase
Synonyms:
2310004P21Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal zygomatic bone morphology Gmprem1(IMPC)Bay HOM   Early adult 4.94×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Electrocardiogram (ECG)

Waveform Image

1 Images

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Eye Morphology

VIP of right eye

16 Images

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X-ray

XRay Images Forepaw

10 Images

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Eye Morphology

VIP of left fundus

16 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Eye Morphology

VIP of right fundus

16 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Eye Morphology

VIP of left eye

16 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Human diseases caused by Gmpr mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gmpr by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Nephrogenic Diabetes Insipidus-Intracranial Calcification-Short Stature-Facial Dysmorphism Syndrome
Carious teeth, Supernumerary tooth, Hypoplasia of the zygomatic bone, Micrognathia ORPHA:3145
Treacher Collins Syndrome 3
Hypoplasia of the zygomatic bone, Micrognathia OMIM:248390
Intellectual Disability-Short Stature-Hypertelorism Syndrome
Hypoplasia of the zygomatic bone ORPHA:3074
Pectus Excavatum-Macrocephaly-Dysplastic Nails Syndrome
Hypoplasia of the zygomatic bone ORPHA:2835
Aortic Arch Anomaly-Facial Dysmorphism-Intellectual Disability Syndrome
Mandibular prognathia, Hypoplasia of the zygomatic bone, Carious teeth ORPHA:1110
Distal 17P13.1 Microdeletion Syndrome
Retrognathia, Hypoplasia of the zygomatic bone ORPHA:319171
Toluene Embryopathy
Hypoplasia of the zygomatic bone, Micrognathia ORPHA:1920
Treacher Collins Syndrome 2
Microretrognathia, Retrognathia, Hypoplasia of the zygomatic bone, Micrognathia OMIM:613717
Facial Dysmorphism-Shawl Scrotum-Joint Laxity Syndrome
Mandibular prognathia, Hypoplasia of the zygomatic bone ORPHA:1778
Nager Syndrome
Hypoplasia of the maxilla, Hypoplasia of the zygomatic bone, Micrognathia ORPHA:245
Pfeiffer Syndrome
Mandibular prognathia, Hypoplasia of the zygomatic bone ORPHA:710
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Hypoplasia of the zygomatic bone ORPHA:1295
Dysostosis, Stanescu Type
Hypoplasia of the maxilla, Hypoplasia of the zygomatic bone, Carious teeth, Abnormal dental ename... ORPHA:1798
X-Linked Mandibulofacial Dysostosis
Hypoplasia of the zygomatic bone, Micrognathia ORPHA:1131
Cleidocranial Dysplasia
Mandibular prognathia, Delayed eruption of teeth, Abnormal dental enamel morphology, Micrognathia... ORPHA:1452
Severe Oculo-Renal-Cerebellar Syndrome
Mandibular prognathia, Hypoplasia of the zygomatic bone ORPHA:2715
Acrofacial Dysostosis, Catania Type
Microretrognathia, Hypoplasia of the zygomatic bone, Carious teeth ORPHA:1786
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome
Carious teeth, Hypoplasia of the zygomatic bone, Abnormal dental enamel morphology, Micrognathia ORPHA:3253
Prolidase Deficiency
Carious teeth, Hypoplasia of the zygomatic bone, Micrognathia ORPHA:742
Flat Face-Microstomia-Ear Anomaly Syndrome
Hypoplasia of the zygomatic bone, Micrognathia ORPHA:1968
Ectodermal Dysplasia-Intellectual Disability-Central Nervous System Malformation Syndrome
Retrognathia, Hypoplasia of the zygomatic bone, Abnormal dental enamel morphology ORPHA:1812
Marshall Syndrome
Hypoplasia of the maxilla, Hypoplasia of the zygomatic bone, Micrognathia ORPHA:560
Antley-Bixler Syndrome
Hypoplasia of the zygomatic bone ORPHA:83
Short Stature, Optic Nerve Atrophy, And Pelger-Huet Anomaly
Hypoplasia of the zygomatic bone OMIM:614800
Chromosome 4Q32.1-Q32.2 Triplication Syndrome
Mandibular prognathia, Microretrognathia, Hypoplasia of the zygomatic bone OMIM:613603
Acro-Renal-Mandibular Syndrome
Hypoplasia of the zygomatic bone, Micrognathia ORPHA:958
Cohen Syndrome
Hypoplasia of the maxilla, Hypoplasia of the zygomatic bone, Micrognathia ORPHA:193
Cutis Gyrata-Acanthosis Nigricans-Craniosynostosis Syndrome
Hypoplasia of the zygomatic bone ORPHA:1555
Hypoglossia-Hypodactyly Syndrome
Hypoplasia of the zygomatic bone, Micrognathia ORPHA:989
Treacher-Collins Syndrome
Abnormal dental enamel morphology, Micrognathia, Hypoplasia of the maxilla, Hypoplasia of the zyg... ORPHA:861
Cardiofaciocutaneous Syndrome
Hypoplasia of the zygomatic bone ORPHA:1340
Pancreatic Agenesis-Holoprosencephaly Syndrome
Hypoplasia of the zygomatic bone ORPHA:556955
Hajdu-Cheney Syndrome
Hypoplasia of the zygomatic bone, Abnormal mandible morphology, Micrognathia ORPHA:955
Holoprosencephaly
Hypoplasia of the zygomatic bone ORPHA:2162
Orofaciodigital Syndrome Type 1
Hypoplasia of the zygomatic bone, Abnormal dental enamel morphology, Micrognathia ORPHA:2750
Ablepharon Macrostomia Syndrome
Hypoplasia of the maxilla, Hypoplasia of the zygomatic bone ORPHA:920
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Hypoplasia of the zygomatic bone OMIM:618500
Charge Syndrome
Delayed eruption of teeth, Hypoplasia of the zygomatic bone ORPHA:138
Williams Syndrome
Abnormal dental enamel morphology, Micrognathia, Carious teeth, Dental malocclusion, Hypoplasia o... ORPHA:904
Ablepharon-Macrostomia Syndrome
Hypoplasia of the zygomatic bone OMIM:200110

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gmpr

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gmpr.

No publications found that use IMPC mice or data for Gmpr.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Gmprtm42454(L1L2_Pgk_PM) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Gmprtm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gmprem1(IMPC)Bay Exon Deletion Mice
Gmprtm2a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gmprtm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Gmprtm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Gmprtm2e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Gmprtm42454(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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