Gene: Smurf2

Order

Name SMAD specific E3 ubiquitin protein ligase 2

Synonyms 2810411E22Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1913563    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Smurf2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Smurf2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Eye with optic nerve - inflammation Smurf2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
preweaning lethality, incomplete penetrance Smurf2tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
decreased hemoglobin content Smurf2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.8E-10
increased heart weight Smurf2tm1b(EUCOMM)Wtsi HET Male postnatal 8.59E-7
thrombocytopenia Smurf2tm1b(EUCOMM)Wtsi HET Male postnatal 3.32E-6
decreased hemoglobin content Smurf2tm1b(EUCOMM)Wtsi HET Male postnatal 3.45E-6
decreased lean body mass Smurf2tm1b(EUCOMM)Wtsi HOM Female Male postnatal 3.54E-6
abnormal head size Smurf2tm1b(EUCOMM)Wtsi HOM Male postnatal 3.41E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No (2/2)
Bone 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Esophagus 2 No (7/415) (1/2)
Eye 2 No (1/2)
Gall bladder 2 No
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (1/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No
Oral epithelium 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584) (1/2)
Trachea 2 No
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    endocrine system
    digestive system
    cardiovascular system
    sensory organ
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (3/4)
Ear 2 (1/485)
Embryo 2 (1/485) (4/4)
Eye 2 (1/485) (1/4)
Foot 2 (1/485) (1/4)
Forebrain 2 (1/485) (2/4)
Forelimb 2 (1/485) (2/4)
Hand 2 (1/485) (1/4)
Head 2 (5/485) (3/4)
Heart 2 (1/485) (2/4)
Hindbrain 2 (6/485) (2/4)
Hindlimb 2 (1/485) (3/4)
Liver 2 (1/485) (1/4)
Lung 2 (1/485) (1/4)
Mandibular process 2 (1/485) (1/4)
Maxillary process 2 (1/485) (1/4)
Midbrain 2 (1/485) (2/4)
Oral cavity 2 (1/485)
Skin 2 (1/485) (1/4)
Tail 2 (1/485) (2/4)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    18 Images
  • X-ray: XRay Images Lateral Orientation
    19 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Dorso Ventral
    19 Images
  • Adult LacZ: LacZ Images Wholemount
    12 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Smurf2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Smurf2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene