Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Pias1 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Immunodeficiency 31B | Recurrent mycobacterial infections, Herpes simplex encephalitis, Recurrent viral infections | OMIM:613796 | |
Cd8 Deficiency, Familial | Recurrent respiratory infections, Recurrent bacterial infections, Bronchiectasis, Recurrent viral... | OMIM:608957 | |
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12Rb1 Deficiency | Tegumentary leishmaniasis susceptibility, Pneumonia, Lymphadenitis, Recurrent mycobacterial infec... | ORPHA:319552 | |
Complement Factor B Deficiency | Pneumonia, Peritonitis, Recurrent bacterial infections, Meningitis, Recurrent meningococcal disease | OMIM:615561 | |
Immunodeficiency 27B | Recurrent mycobacterial infections, Osteomyelitis, Recurrent mycobacterium avium complex infectio... | OMIM:615978 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pias1.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Pias1 is essential for erythroid and vascular development in the mouse embryo. | Developmental biology (May 2016) | Pias1tm1a(KOMP)Wtsi | PMC4906794 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Pias1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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