Gene: Bbox1

Order

Name butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)

Status ES CellsMice
tm1a
Mice
em1
Mice
em2
Mice
tm1b
phenotype data available

Links MGI:1891372    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Bbox1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Bbox1 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Bbox1tm1b(KOMP)Wtsi HOM Female embryonic day 12.5 0.0
abnormal forebrain morphology Bbox1tm1b(KOMP)Wtsi HOM Female embryonic day 12.5 0.0
abnormal hindbrain morphology Bbox1tm1b(KOMP)Wtsi HOM Female embryonic day 12.5 0.0
abnormal midbrain morphology Bbox1tm1b(KOMP)Wtsi HOM Female embryonic day 12.5 0.0
abnormal neural tube closure Bbox1tm1b(KOMP)Wtsi HOM Female embryonic day 12.5 0.0
enlarged heart Bbox1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
male infertility Bbox1tm1a(KOMP)Wtsi HOM Male postpartum stage 0.0
preweaning lethality, incomplete penetrance Bbox1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
prolonged RR interval Bbox1tm1a(KOMP)Wtsi HOM Female Male postnatal 1.95E-6
decreased heart rate Bbox1tm1a(KOMP)Wtsi HOM Female Male postnatal 4.07E-6
abnormal behavior Bbox1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.5E-5
increased heart weight Bbox1tm1b(KOMP)Wtsi HOM Female Male postnatal 4.33E-5
increased body length Bbox1tm1b(KOMP)Wtsi HOM Female postnatal 8.11E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 8 No (2/415)
Aorta 8 No
Blood 2 No
Bone 6 No (2/6)
Bone marrow 2 No
Brain 8 No (6/8)
Brainstem 8 No (4/8)
Brown adipose tissue 8 No
Cartilage tissue 8 No (6/8)
Cecum 4 No (12/383)
Cerebellum 8 No (4/8)
Cerebral cortex 8 No
Chest bone 2 No
Colon 2 No (12/127)
Diaphragm 2 No
Duodenum 2 No (2/127)
Epididymis 4 No (18/134) (1/4)
Esophagus 8 No (7/415) (2/8)
Eye 8 No
Gall bladder 6 No
Gonadal fat pad 2 No
Harderian gland 2 No
Heart 8 No
Hindlimb 2 No
Hippocampus 8 No
Hypothalamus 8 No
Ileum 2 No (14/127) (1/2)
Jejunum 2 No (6/127) (1/2)
Kidney 8 No (18/584) (8/8)
Large intestine 8 No (10/584) (2/8)
Liver 8 No (3/8)
Lower urinary tract 8 No (4/8)
Lung 8 No (4/8)
Lymph node 8 No
Mammary gland 8 No
Mesenteric lymph node 2 No
Mesenteric adipose tissue 2 No
Midbrain 4 No (4/4)
Olfactory lobe 8 No
Oral epithelium 4 No (2/4)
Ovary 8 No (1/584) (1/8)
Oviduct 8 No (4/8)
Pancreas 8 No (5/584)
Parathyroid gland 6 No
Parotid gland 2 No
Penis 2 No (1/2)
Peripheral nervous system 8 No (2/8)
Peyer's patch 8 No
Pituitary gland 8 No
Prostate gland 8 No (12/584) (2/8)
Quadriceps 2 No
Sciatic nerve 2 No
Skeletal muscle 8 No
Skin 8 No (8/8)
Small intestine 8 No (9/584) (3/8)
Spinal cord 8 No (6/8)
Spleen 8 No (2/584)
Stomach 8 No (12/584) (6/8)
Stomach pyloric region 2 No
Striatum 8 No (2/8)
Sublingual gland 2 No
Submandibular gland 4 No (2/132) (1/4)
Testis 8 No (2/584) (4/8)
Thalamus 2 No
Thymus 8 No
Thyroid gland 8 No (15/584) (3/8)
Tongue 2 No (5/127) (1/2)
Trachea 8 No (2/8)
Trigeminal V nerve 4 No
Urinary bladder 4 No (2/4)
Uterus 8 No (2/8)
Vagina 2 No
Vas deferens 4 No (15/388) (1/4)
Vascular system 8 No
Vesicular gland 4 No
White adipose tissue 8 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    digestive system
    set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • exocrine system(1)
    Lower Urinary Tract expression
    Prostate gland expression
    MA:0002636
    MA:0000404

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 3 (1/47)
Axial skeleton 3 (1/51)
Brain 6 (6/485) (3/7)
Central nervous system ganglion 3 (1/51)
Cranium 3 (1/46)
Dorsal root ganglion 5 (1/47) (2/5)
Ear 6 (1/485)
Embryo 6 (1/485) (6/7)
Outer ear 3 (1/47)
Eye 6 (1/485)
Femur pre-cartilage condensation 3 (1/46) (2/3)
Foot 6 (1/485) (1/7)
Forearm 3 (1/282) (2/3)
Forebrain 6 (1/485)
Forelimb 6 (1/485) (6/7)
Fronto-nasal process 5 (1/48)
Gut 3 (1/50)
Hand 6 (1/485) (1/7)
Head 6 (5/485) (4/7)
Head mesenchyme 3 (1/47)
Heart 6 (1/485)
Heart ventricle 3 (1/47)
Hindbrain 6 (6/485) (2/7)
Hindlimb 6 (1/485) (6/7)
Humerus pre-cartilage condensation 3 (1/46) (2/3)
Inner ear 3 (1/46)
Intestine 3 (1/47)
Liver 6 (1/485)
Lower leg 3 (1/282)
Lung 6 (1/485)
Mandibular process 6 (1/485)
Maxillary process 6 (1/485) (3/7)
Mesonephros of female 3 (1/46)
Mesonephros of male 3 (1/46)
Metanephros 3 (1/46)
Midbrain 6 (1/485)
Nasal septum 3 (1/47)
Nose 5 (1/51)
Notochord 3 (1/47) (2/3)
Oral cavity 6 (1/485)
Outflow tract 3 (1/47)
Pancreas 3 (1/46)
Pericardium 3 (1/46)
Pharynx 3 (1/46)
Radius-ulna pre-cartilage condensation 3 (1/46) (2/3)
Rib pre-cartilage condensation 3 (1/46)
Skeleton 3 (1/51)
Skin 6 (1/485)
Spinal cord 5 (1/50) (3/5)
Stomach 3 (1/46)
Tail 6 (1/485) (1/7)
Tail somite 6 (1/485)
Thoracic vertebral cartilage condensation 4 (1/46) (1/4)
Tongue 3 (1/46)
Trachea 3 (1/50)
Trunk mesenchyme 3 (1/47)
Umbilical artery embryonic part 3 (1/47)
Umbilical vein embryonic part 3 (1/47)
Upper arm 3 (1/282) (2/3)
Upper leg 3 (1/282) (2/3)
Urinary system 3 (1/50)
Vibrissa 3 (1/47)


Associated Images

Associated Images
  • Echo: M-Mode Images
    32 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Embryo LacZ: LacZ images wholemount
    21 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    19 Images
  • X-ray: XRay Images Dorso Ventral
    20 Images
  • Adult LacZ: LacZ Images Wholemount
    28 Images
  • X-ray: XRay Images Lateral Orientation
    21 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Forepaw
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Bbox1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Fixed Tissue
Bbox1em1(IMPC)Bay Exon Deletion
Vector
Gene
Bbox1em2(IMPC)Bay Conditional Ready
Vector
Gene
Bbox1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Bbox1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Bbox1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene