Gene: Stx8

Order

Name syntaxin 8

Synonyms
  • 0610007H08Rik
  • 1110002H11Rik
  • 4930571E13Rik

Status ES CellsMice
tm2a
phenotype data available

Links MGI:1890156    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Stx8

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Stx8 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
alopecia Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 1.18E-19
mammalian phenotype Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 1.18E-19
decreased circulating creatinine level Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 5.64E-13
decreased circulating alkaline phosphatase level Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 1.97E-9
decreased circulating HDL cholesterol level Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 3.48E-8
decreased body weight Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 1.34E-7
decreased circulating cholesterol level Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 8.57E-7
decreased bone mineral density Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 6.51E-6
abnormal response to tactile stimuli Stx8tm2a(EUCOMM)Wtsi HOM Female Male postnatal 6.77E-6
tremors Stx8tm2a(EUCOMM)Wtsi HOM Male postnatal 6.92E-6
increased total body fat amount Stx8tm2a(EUCOMM)Wtsi HOM Female postnatal 9.45E-6
increased heart weight Stx8tm2a(EUCOMM)Wtsi HOM Female postnatal 1.35E-5
trunk curl Stx8tm2a(EUCOMM)Wtsi HOM Female postnatal 3.1E-5
increased circulating glucose level Stx8tm2a(EUCOMM)Wtsi HOM Male postnatal 4.76E-5
abnormal response to new environment Stx8tm2a(EUCOMM)Wtsi HOM Male postnatal 7.12E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (1/2)
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/2)
Cerebellum 2 No
Cerebral cortex 2 No
Eye 2 No (1/2)
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (1/2)
Uterus 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system respiratory system nervous system set of connective tissues sensory organ reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (14)
  • Stx8tm2a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    heart, HET, Female, WTSI

show all 14 images

trunk (8)
  • Stx8tm2a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    trachea, HET, Female, WTSI

show all 8 images

nervous system (5)
  • Stx8tm2a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    pituitary gland, peripheral nervous system, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    spinal cord, HET, Male, WTSI
reproductive system (2)
  • Stx8tm2a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
urinary system (2)
  • Stx8tm2a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
cardiovascular system (1)
  • Stx8tm2a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
endocrine system (1)
  • Stx8tm2a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
respiratory system (1)
  • Stx8tm2a(EUCOMM)Wtsi
    trachea, HET, Female, WTSI
sensory organ (1)
  • Stx8tm2a(EUCOMM)Wtsi
    eye, HET, Male, WTSI
set of connective tissues (1)
  • Stx8tm2a(EUCOMM)Wtsi
    cartilage tissue, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (113)
  • Stx8tm2a(EUCOMM)Wtsi
    head, WT, Male, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    forearm, WT, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    body, WT, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    head, WT, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    body, WT, Male, WTSI

show all 113 images

Skin Histopathology (3)
  • Stx8tm2a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI
  • Stx8tm2a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Stx8tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Stx8tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Stx8tm3a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene