Gene: Cpsf3

Order

Name cleavage and polyadenylation specificity factor 3

Synonyms 73 kDa

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1859328    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal     Homozygous - Subviable

Phenotype associations for Cpsf3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cpsf3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Cpsf3tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
preweaning lethality, incomplete penetrance Cpsf3tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/4)
Aorta 4 No (1/4)
Blood vessel 4 No
Bone 4 No
Brain 4 No (4/4)
Brainstem 4 No (4/4)
Brown adipose tissue 4 No
Cartilage tissue 4 No
Cerebellum 4 No (4/4)
Cerebral cortex 4 No (4/4)
Eye 4 No
Gall bladder 4 No (1/4)
Heart 4 No (4/4)
Hippocampus 4 No (4/4)
Hypothalamus 4 No (4/4)
Kidney 4 No (18/584) (4/4)
Large intestine 4 No (10/584)
Liver 4 No
Lower urinary tract 4 No (4/4)
Lung 4 No (2/4)
Lymph node 4 No
Mammary gland 4 No
Esophagus 4 No (2/4)
Olfactory lobe 4 No (4/4)
Ovary 4 No (1/584) (2/4)
Oviduct 4 No (2/4)
Pancreas 4 No (5/584) (4/4)
Parathyroid gland 4 No (4/4)
Peripheral nervous system 4 No (2/4)
Peyer's patch 4 No
Pituitary gland 4 No (3/4)
Prostate gland 4 No (12/584)
Skeletal muscle tissue 4 No
Skin 4 No
Small intestine 4 No (9/584)
Spinal cord 4 No (4/4)
Spleen 4 No (2/584)
Stomach 4 No (12/584) (1/4)
Striatum 4 No (4/4)
Testis 4 No (2/584) (2/4)
Thymus 4 No
Thyroid gland 4 No (15/584)
Trachea 4 No (4/4)
Uterus 4 No (2/4)
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system endocrine system digestive system cardiovascular system nervous system reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (32)
  • Cpsf3tm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    olfactory lobe, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    lung, HET, Female, WTSI

show all 32 images

trunk (24)
  • Cpsf3tm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI

show all 24 images

nervous system (8)
  • Cpsf3tm1a(EUCOMM)Wtsi
    olfactory lobe, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    spinal cord, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    pituitary gland, HET, Male, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    spinal cord, HET, Male, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    hypothalamus, HET, Female, WTSI

show all 8 images

digestive system (5)
  • Cpsf3tm1a(EUCOMM)Wtsi
    oesophagus, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    gall bladder, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    oesophagus, HET, Male, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    large intestine, HET, Male, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    stomach, HET, Male, WTSI
endocrine system (4)
  • Cpsf3tm1b(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    parathyroid gland, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    parathyroid gland, HET, Male, WTSI
reproductive system (4)
  • Cpsf3tm1a(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    uterus, HET, Female, WTSI
urinary system (4)
  • Cpsf3tm1a(EUCOMM)Wtsi
    lower urinary tract, urinary bladder, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    kidney, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
cardiovascular system (2)
  • Cpsf3tm1a(EUCOMM)Wtsi
    aorta, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    aorta, HET, Female, WTSI
respiratory system (2)
  • Cpsf3tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    lung, HET, Female, WTSI
musculoskeletal system (1)
  • Cpsf3tm1a(EUCOMM)Wtsi
    bone, rib, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    27 Images
  • X-ray: XRay Images Lateral Orientation
    55 Images
  • X-ray: XRay Images Dorso Ventral
    83 Images
  • X-ray: XRay Images Skull Lateral Orientation
    27 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    28 Images
  • Eye Morphology: Images Ophthalmoscopy
    1 Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (138)
  • Cpsf3tm1a(EUCOMM)Wtsi
    HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    HET, Female, WTSI

show all 138 images

Histology Slide (13)
  • Cpsf3tm1a(EUCOMM)Wtsi
    TS20 hindlimb, HET, Unsexed, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    TS20 maxillary process, HET, Unsexed, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    TS20 oral cavity, HET, Unsexed, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    TS20 oral cavity, HET, Unsexed, WTSI
  • Cpsf3tm1b(EUCOMM)Wtsi
    TS20 tail, TS20 tail somite group, HET, Male, WTSI

show all 13 images

Eye Morphology (2)
  • Cpsf3tm1b(EUCOMM)Wtsi
    Fused cornea and lens, HET, Female, WTSI
  • Cpsf3tm1a(EUCOMM)Wtsi
    right eye, abnormal retinal pigmentation, HET, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cpsf3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Cpsf3tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene