Gene: Uba2

Order

Name ubiquitin-like modifier activating enzyme 2

Synonyms
  • anthracycline-associated resistance
  • Uble1b
  • Sumo-1 activating enzyme subunit 2
  • UBA2
  • SAE2
  • Arx

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1858313    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Uba2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Uba2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Uba2tm1a(KOMP)Wtsi HOM Female Male n/a 0.0

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 3 No (2/3)
Aorta 3 No
Blood vessel 3 No (3/3)
Bone 3 No
Brain 3 No (3/3)
Brainstem 3 No
Brown adipose tissue 3 No
Cartilage tissue 3 No (3/3)
Cerebellum 3 No
Cerebral cortex 3 No
Eye 3 No (3/3)
Gall bladder 3 No (3/3)
Heart 3 No (3/3)
Hippocampus 3 No
Hypothalamus 3 No
Kidney 3 No (18/584) (3/3)
Large intestine 3 No (10/584) (3/3)
Liver 3 No (3/3)
Lower urinary tract 3 No (3/3)
Lung 3 No (3/3)
Lymph node 3 No (3/3)
Mammary gland 3 No
Esophagus 3 No (3/3)
Olfactory lobe 3 No
Ovary 3 No (1/584) (1/3)
Oviduct 3 No (1/3)
Pancreas 3 No (5/584)
Parathyroid gland 3 No (3/3)
Peripheral nervous system 3 No (3/3)
Peyer's patch 3 No (3/3)
Pituitary gland 3 No (3/3)
Prostate gland 3 No (12/584) (2/3)
Skeletal muscle tissue 3 No (3/3)
Skin 3 No (3/3)
Small intestine 3 No (9/584) (3/3)
Spinal cord 3 No (3/3)
Spleen 3 No (2/584) (3/3)
Stomach 3 No (12/584) (3/3)
Striatum 3 No
Testis 3 No (2/584) (2/3)
Thymus 3 No (3/3)
Thyroid gland 3 No (15/584)
Trachea 3 No (3/3)
Uterus 3 No (1/3)
White adipose tissue 3 No (1/3)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system endocrine system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system adipose tissue trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (27)
  • Uba2tm1a(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Uba2tm1a(KOMP)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI

show all 27 images

trunk (15)
  • Uba2tm1a(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Uba2tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    kidney, HET, Male, WTSI

show all 15 images

nervous system (5)
  • Uba2tm1a(KOMP)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    brain, HET, Male, WTSI
  • Uba2tm1a(KOMP)Wtsi
    brain, HET, Male, WTSI
  • Uba2tm1a(KOMP)Wtsi
    spinal cord, HET, Male, WTSI
  • Uba2tm1a(KOMP)Wtsi
    pituitary gland, HET, Male, WTSI
digestive system (4)
  • Uba2tm1a(KOMP)Wtsi
    large intestine, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    liver, gall bladder, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    oesophagus, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    peyer's patch, HET, Female, WTSI
immune system (4)
  • Uba2tm1a(KOMP)Wtsi
    thymus, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    spleen, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    peyer's patch, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    lymph node, HET, Female, WTSI
reproductive system (3)
  • Uba2tm1a(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Uba2tm1a(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
endocrine system (2)
  • Uba2tm1a(KOMP)Wtsi
    parathyroid gland, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
sensory organ (2)
  • Uba2tm1a(KOMP)Wtsi
    skin, pinna, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    eye, HET, Female, WTSI
set of connective tissues (2)
  • Uba2tm1a(KOMP)Wtsi
    cartilage tissue, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    cartilage tissue, HET, Male, WTSI
urinary system (2)
  • Uba2tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    kidney, HET, Male, WTSI
cardiovascular system (1)
  • Uba2tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
exocrine system (1)
  • Uba2tm1a(KOMP)Wtsi
    prostate gland, HET, Male, WTSI
integumental system (1)
  • Uba2tm1a(KOMP)Wtsi
    skin, pinna, HET, Female, WTSI
musculoskeletal system (1)
  • Uba2tm1a(KOMP)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
respiratory system (1)
  • Uba2tm1a(KOMP)Wtsi
    lung, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (105)
  • Uba2tm1a(KOMP)Wtsi
    head, WT, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    body, WT, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    body, WT, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    forearm, WT, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    body, WT, Female, WTSI

show all 105 images

Skin Histopathology (3)
  • Uba2tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI
  • Uba2tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI
Eye Morphology (2)
  • Uba2tm1a(KOMP)Wtsi
    eye, abnormal placement of pupils, HET, Male, WTSI
  • Uba2tm1a(KOMP)Wtsi
    eye, abnormal pupil morphology, abnormal placement of pupils, HET, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Uba2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Uba2tm303057(L1L2_Bact_P)
Vector
Gene
Uba2tm37390(L1L2_Bact_P)
Vector
Gene