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Gene: Ndrg2 MGI:1352498

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
N-myc downstream regulated gene 2
Synonyms:
Ndr2

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ndrg2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ndrg2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Serrated Polyposis Syndrome
Ovarian neoplasm, Pancreatic adenocarcinoma, Germ cell neoplasia, Colorectal polyposis, Gastric d... ORPHA:157798
Melanoma-Pancreatic Cancer Syndrome
Squamous cell carcinoma, Oropharyngeal squamous cell carcinoma, Melanoma, Sarcoma, Pancreatic ade... OMIM:606719
Hereditary Breast And/Or Ovarian Cancer Syndrome
Neoplasm of the pancreas, Ovarian neoplasm, Abnormal fallopian tube morphology, Primary peritonea... ORPHA:145
Pancreatic Cancer, Susceptibility To, 5
Pancreatic adenocarcinoma, Melanoma OMIM:618680
Li-Fraumeni Syndrome
Rhabdomyosarcoma, Neoplasm of the pancreas, Neoplasm of the larynx, Choriocarcinoma, Hodgkin lymp... ORPHA:524
Li-Fraumeni Syndrome
Acute leukemia, Prostate neoplasm, Neoplasm of the pancreas, Soft tissue sarcoma, Choriocarcinoma... OMIM:151623
Cervical Vertebral Dysplasia
Anterior atlanto-occipital dislocation, Cervical vertebral facet hypoplasia, Cervical vertebral d... OMIM:118005
Nut Midline Carcinoma
Pancreatic squamous cell carcinoma, Squamous cell carcinoma, Oropharyngeal squamous cell carcinom... ORPHA:443167
Subependymoma
Spinal cord tumor, Ovarian neoplasm, Ependymoma, Neoplasm of the lung, Neoplasm of the breast, Su... ORPHA:251639
Ependymoma
Spinal cord tumor, Ovarian neoplasm, Ependymoma, Neoplasm of the lung, Neoplasm of the breast, Su... ORPHA:251636
Pancreatic Cancer
Neoplasm of the pancreas OMIM:260350
Cutaneous Neuroendocrine Carcinoma
Basal cell carcinoma, Merkel cell skin cancer, Squamous cell carcinoma of the skin, Brain neoplas... ORPHA:79140
Tumor Predisposition Syndrome 1
Malignant mesothelioma, Uveal melanoma, Renal cell carcinoma, Meningioma, Lung adenocarcinoma, Cu... OMIM:614327
Gcgr-Related Hyperglucagonemia
Glucagonoma, Neoplasm of the pancreas, Cholelithiasis, Abnormal biliary tract morphology ORPHA:438274
Familial Adenomatous Polyposis 3
Basal cell carcinoma, Pancreatic adenocarcinoma, Breast carcinoma, Prostate cancer, Bladder neopl... OMIM:616415
Gardner Syndrome
Neoplasm of the pancreas, Lipoma, Odontoma, Ampulla of Vater carcinoma, Desmoid tumors, Multiple ... ORPHA:79665
Familial Melanoma
Neoplasm of the breast, Neoplasm of the stomach, Neoplasm of the pancreas, Melanoma ORPHA:618
Pancreatic Cancer, Susceptibility To, 1
Pancreatic adenocarcinoma OMIM:606856
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Basal cell carcinoma, Pancreatic adenocarcinoma, Neoplasm of the rectum, Squamous cell carcinoma,... ORPHA:454840
Pancreatic Cancer, Susceptibility To, 2
Neoplasm of the pancreas OMIM:613347
Prostate Cancer/Brain Cancer Susceptibility
Prostate cancer, Neoplasm of the central nervous system OMIM:603688
Apc-Related Attenuated Familial Adenomatous Polyposis
Neoplasm of the pancreas, Lipoma, Odontoma, Desmoid tumors, Fibroadenoma of the breast, Duodenal ... ORPHA:247806
Polymerase Proofreading-Related Adenomatous Polyposis
Neoplasm of the rectum, Colorectal polyposis, Adenomatous colonic polyposis, Brain neoplasm, Aden... ORPHA:447877
Lynch Syndrome 5
Hereditary nonpolyposis colorectal carcinoma, Neoplasm of the pancreas, Ovarian neoplasm, Endomet... OMIM:614350
Punctate Palmoplantar Keratoderma Type 1
Esophageal neoplasm, Basal cell carcinoma, Squamous cell carcinoma, Stomach cancer, Renal cell ca... ORPHA:79501
Hyperparathyroidism 2 With Jaw Tumors
Parathyroid carcinoma, Renal cortical adenoma, Recurrent pancreatitis, Papillary renal cell carci... OMIM:145001
Desmoplastic Small Round Cell Tumor
Neoplasm of the central nervous system, Neoplasm of the pancreas, Ovarian neoplasm, Hepatomegaly,... ORPHA:83469
Insulinoma Tumor Suppressor Gene Locus
Insulinoma OMIM:606960
Infantile Myofibromatosis
Fibroma, Intestinal obstruction, Neoplasm of the pancreas, Gingival fibromatosis, Neoplasm of the... ORPHA:2591
Familial Adenomatous Polyposis
Lipoma, Odontoma, Pituitary adenoma, Desmoid tumors, Neoplasm of the gastrointestinal tract, Duod... ORPHA:733
Schwannomatosis 1
Spinal cord tumor, Meningioma, Peripheral schwannoma, Vestibular schwannoma OMIM:162091
Ankylosing Vertebral Hyperostosis With Tylosis
Vertebral hyperostosis OMIM:106400
Spondylocostal Dysostosis 6, Autosomal Recessive
Butterfly vertebrae, Scoliosis, Hemivertebrae, Spinal canal stenosis, Cervical kyphosis OMIM:616566
Primary Basilar Invagination
Short neck, Abnormal vertebral morphology, Abnormality of the cervical spine ORPHA:2285
Tumor Predisposition Syndrome 4
Stomach cancer, Glioma, Sarcoma, Meningioma, Breast carcinoma OMIM:609265
Glioma Susceptibility 3
Acute myeloid leukemia, Medulloblastoma, Astrocytoma, B Acute Lymphoblastic Leukemia, Glioblastom... OMIM:613029
Lung Cancer
Alveolar cell carcinoma, Lung adenocarcinoma, Non-small cell lung carcinoma OMIM:211980
Turcot Syndrome With Polyposis
Intestinal polyposis, Cerebellar medulloblastoma, Pituitary adenoma, Desmoid tumors, Neoplasm of ... ORPHA:99818
Peutz-Jeghers Syndrome
Esophageal neoplasm, Intestinal obstruction, Rectal prolapse, Abnormality of the gallbladder, Neo... ORPHA:2869
Familial Multinodular Goiter
Basal cell carcinoma, Thyroid carcinoma, Ovarian neoplasm, Pleuropulmonary blastoma, Colorectal p... ORPHA:276399
Familial Colorectal Cancer Type X
Neoplasm of the thyroid gland, Basal cell carcinoma, Neoplasm of the pancreas, Neoplasm of the re... ORPHA:440437
Mismatch Repair Cancer Syndrome 1
Basal cell carcinoma, T-cell lymphoma, Rhabdomyosarcoma, Pleomorphic xanthoastrocytoma, Leukemia,... OMIM:276300
Peripheral Primitive Neuroectodermal Tumor
Spinal cord tumor, Neoplasm of the pancreas, Ovarian neoplasm, Jaundice, Pancreatitis, Brain neop... ORPHA:370348
Lynch Syndrome
Neoplasm of the stomach, Neoplasm of the pancreas, Intestinal polyposis, Neoplasm of the skin, Ma... ORPHA:144
Von Hippel-Lindau Syndrome
Hepatic hemangioma, Pulmonary capillary hemangiomatosis, Neoplasm of the pancreas, Spinal hemangi... OMIM:193300
Osteomesopyknosis
Scoliosis, Sclerotic vertebral body, Kyphosis, Abnormal form of the vertebral bodies ORPHA:2777
Tropical Calcific Pancreatitis
Neoplasm of the pancreas, Chronic pancreatitis, Pancreatic calcification OMIM:608189
Vertebral Hypoplasia With Lumbar Kyphosis
Vertebral hypoplasia, Lumbar kyphosis OMIM:192900
Rhabdoid Tumor Predisposition Syndrome 1
Medulloblastoma, Choroid plexus carcinoma OMIM:609322
Pleuropulmonary Blastoma
Medulloblastoma, Rhabdomyosarcoma, Pleuropulmonary blastoma OMIM:601200
Colorectal Cancer, Susceptibility To, 12
Carcinoma, Colorectal polyposis OMIM:615083
Basal Cell Nevus Syndrome 2
Basal cell carcinoma, Medulloblastoma, Meningioma, Neurofibroma, Angiofibromas OMIM:620343
Familial Adenomatous Polyposis 1
Fibroma, Osteoma, Duodenal polyposis, Adrenocortical adenoma, Adenomatous colonic polyposis, Carc... OMIM:175100
Spondylocostal Dysostosis 2, Autosomal Recessive
Hemivertebrae, Vertebral segmentation defect, Vertebral clefting, Rib fusion, Short neck OMIM:608681
Peutz-Jeghers Syndrome
Rectal prolapse, Neoplasm of the pancreas, Gastrointestinal carcinoma, Precocious puberty with Se... OMIM:175200
Familial Pancreatic Carcinoma
Jaundice, Elevated circulating hepatic transaminase concentration, Pancreatic adenocarcinoma, Int... ORPHA:1333
Acrodysplasia Scoliosis
Scoliosis, Vertebral segmentation defect, Spina bifida occulta ORPHA:2956
Ovarian Cancer
Dysgerminoma, Ovarian papillary adenocarcinoma, Breast carcinoma OMIM:167000
Breast-Ovarian Cancer, Familial, Susceptibility To, 2
Ovarian neoplasm, Breast carcinoma OMIM:612555
Breast-Ovarian Cancer, Familial, Susceptibility To, 1
Ovarian neoplasm, Breast carcinoma OMIM:604370
Breast-Ovarian Cancer, Familial, Susceptibility To, 3
Ovarian carcinoma, Breast carcinoma OMIM:613399
Medulloblastoma
Medulloblastoma OMIM:155255
Spondylosis, Cervical
Spondylolysis, Cervical spondylosis, Spondylolisthesis, Spina bifida occulta OMIM:184300
Tropical Pancreatitis
Jaundice, Abnormal pancreatic duct morphology, Pancreatic calcification, Pancreatic adenocarcinom... ORPHA:103918
Cancer-Associated Retinopathy
Neoplasm of the pancreas, Small cell lung carcinoma, Testicular neoplasm, Female reproductive sys... ORPHA:71505
Thyroid Cancer, Nonmedullary, 4
Basal cell carcinoma, Ovarian neoplasm, Papillary thyroid carcinoma, Prostate cancer, Goiter OMIM:616534
Grfoma
Intestinal obstruction, Neoplasm of the pancreas, Pheochromocytoma, Pituitary adenoma, Parathyroi... ORPHA:97261
Spondylocostal Dysostosis 3, Autosomal Recessive
Supernumerary vertebral ossification centers, Scoliosis, Vertebral segmentation defect, Kyphosis,... OMIM:609813
Epidermodysplasia Verruciformis, Susceptibility To, 2
Squamous cell carcinoma of the skin, Verruca plana OMIM:618231
Pilomatrixoma
Pilomatrixoma, Neoplasm of head and neck ORPHA:91414
Klippel-Feil Syndrome 3, Autosomal Dominant
Thoracic scoliosis, Cervical C3/C4 vertebral fusion, Cervical C5/C6 vertebrae fusion OMIM:613702
Ppoma
Intestinal obstruction, Neoplasm of the pancreas, Intrahepatic cholestasis, Hepatomegaly, Choleli... ORPHA:97278
Muir-Torre Syndrome
Basal cell carcinoma, Adenoma sebaceum, Ovarian neoplasm, Malignant genitourinary tract tumor, Be... OMIM:158320
Insulinomatosis And Diabetes Mellitus
Insulinoma, Multiple pancreatic beta-cell adenomas OMIM:147630
Maffucci Syndrome
Neoplasm of the parathyroid gland, Hemangiomatosis, Ovarian neoplasm, Neoplasm of the adrenal cor... ORPHA:163634
Von Hippel-Lindau Disease
Neoplasm of the pancreas, Pancreatic endocrine tumor, Adrenal pheochromocytoma, Retinal capillary... ORPHA:892
Progeria-Short Stature-Pigmented Nevi Syndrome
Neoplasm of the pancreas, Elevated circulating hepatic transaminase concentration, Hypospadias, H... ORPHA:2959
Vipoma
Neoplasm of the pancreas, Intrahepatic cholestasis, Hepatomegaly, Increased circulating gonadotro... ORPHA:97282
Carney Complex
Neoplasm of the stomach, Ductal carcinoma in situ, Neoplasm of the pancreas, Pituitary growth hor... ORPHA:1359
Somatostatinoma
Intestinal obstruction, Steatorrhea, Neoplasm of the pancreas, Intrahepatic cholestasis, Gallblad... ORPHA:97283
Multiple Endocrine Neoplasia Type 1
Duodenal ulcer, Neoplasm of the pancreas, Pheochromocytoma, Pituitary growth hormone cell adenoma... ORPHA:652
Blue Rubber Bleb Nevus
Rectal prolapse, Cerebellar medulloblastoma, Hemangioma, Volvulus, Intestinal bleeding, Abnormali... OMIM:112200
Pheochromocytoma/Paraganglioma Syndrome 4
Chemodectoma, Adrenal pheochromocytoma, Renal cell carcinoma, Gastrointestinal stroma tumor, Para... OMIM:115310
Hyperparathyroidism-Jaw Tumor Syndrome
Fibroma, Peptic ulcer, Thyroid carcinoma, Pancreatitis, Lipoma, Testicular neoplasm, Renal hamart... ORPHA:99880
Bazex Syndrome
Liposarcoma, Lung adenocarcinoma, Neoplasm ORPHA:166113
Parathyroid Carcinoma
Fibroma, Parathyroid carcinoma, Thyroid carcinoma, Peptic ulcer, Pancreatitis, Lipoma, Testicular... ORPHA:143
Tumor Predisposition Syndrome 2
Ductal carcinoma in situ, Acute myeloid leukemia, Uveal melanoma, Juvenile type ovarian granulosa... OMIM:619975
Schöpf-Schulz-Passarge Syndrome
Basal cell carcinoma, Ovarian neoplasm, Squamous cell carcinoma ORPHA:50944
Opsoclonus-Myoclonus Syndrome
Small cell lung carcinoma, Neoplasm of the lung, Ovarian teratoma, Melanoma, Neuroblastoma, Breas... ORPHA:1183
Gastrointestinal Stromal Tumor
Esophageal neoplasm, Neoplasm of the stomach, Intestinal obstruction, Neoplasm of the rectum, Neo... ORPHA:44890
Mosaic Variegated Aneuploidy Syndrome 7 With Inflammation And Tumor Predisposition
Lipoma, Pilomatrixoma, Adenocarcinoma of the colon, Embryonal rhabdomyosarcoma, Multinodular goit... OMIM:620189
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin, Sex reversal ORPHA:85112
Epidermodysplasia Verruciformis, Susceptibility To, 5
Verrucae, Squamous cell carcinoma of the skin OMIM:618309
Glucagonoma
Intestinal obstruction, Steatorrhea, Neoplasm of the pancreas, Intrahepatic cholestasis, Hepatome... ORPHA:97280
17Q11 Microdeletion Syndrome
Rhabdomyosarcoma, Cerebellar glioma, Multiple mucosal neuromas, Pheochromocytoma, Glomus jugular ... ORPHA:97685
Medulloblastoma
Spinal cord tumor, Elevated circulating hepatic transaminase concentration, Cerebellar medullobla... ORPHA:616
Rhabdomyosarcoma, Embryonal, 2
Pleuropulmonary blastoma, Ovarian thecoma, Multinodular goiter, Embryonal rhabdomyosarcoma, Goite... OMIM:180295
Dyskeratosis Congenita
Cirrhosis, Neoplasm of the pancreas, Hepatomegaly, Esophageal stenosis, Lymphoma, Tracheoesophage... ORPHA:1775
Gastrointestinal Stromal Tumor
Neurofibroma, Intestinal obstruction, Gastrointestinal stroma tumor OMIM:606764
Juvenile Polyposis Syndrome
Neoplasm of the pancreas, Hepatic arteriovenous malformation, Protein-losing enteropathy, Stomach... ORPHA:2929
Pilomatrixoma
Pilomatrixoma OMIM:132600
Neuroblastoma, Susceptibility To, 2
Neuroblastoma, Ganglioneuroblastoma, Aganglionic megacolon, Ganglioneuroma OMIM:613013
Retinoblastoma
Retinoblastoma, Lymphoma, Ewing sarcoma, Cleft palate, Osteosarcoma, Pinealoma, Leukemia OMIM:180200
Gist-Plus Syndrome
Intussusception, Intestinal polyposis, Gastrointestinal stroma tumor OMIM:175510
Lynch Syndrome 4
Hereditary nonpolyposis colorectal carcinoma, Endometrial carcinoma, Ovarian neoplasm OMIM:614337
Legius Syndrome
Ovarian neoplasm, Acute monocytic leukemia, Non-small cell lung carcinoma, Desmoid tumors, Nephro... ORPHA:137605
Congenital Central Hypoventilation Syndrome
Neoplasm of the central nervous system, Aganglionic megacolon, Neuroblastoma, Ganglioneuroma, Gan... ORPHA:661
Gonadoblastoma
Female external genitalia in individual with 46,XY karyotype, Abnormality of the ovary, Ovarian g... ORPHA:206484
Fanconi Renotubular Syndrome 5
Lung adenocarcinoma OMIM:618913
Familial Multiple Lipomatosis
Medulloblastoma, Odontogenic keratocysts of the jaw ORPHA:199276
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Steinert Myotonic Dystrophy
Decreased response to growth hormone stimulation test, Male hypogonadism, Elevated circulating he... ORPHA:273
Fanconi Anemia, Complementation Group N
Acute myeloid leukemia, Anal atresia, Medulloblastoma, Neuroblastoma, Nephroblastoma OMIM:610832
Gorlin Syndrome
Basal cell carcinoma, Odontogenic keratocysts of the jaw, Ovarian fibroma, Medulloblastoma, Cardi... ORPHA:377
Carney-Stratakis Syndrome
Intestinal obstruction, Paraganglioma, Gastrointestinal stroma tumor ORPHA:97286
Basal Cell Nevus Syndrome 1
Basal cell carcinoma, Cardiac rhabdomyoma, Odontogenic keratocysts of the jaw, Hamartomatous stom... OMIM:109400
Acquired Hypertrichosis Lanuginosa
Ovarian neoplasm, Glossitis, Neoplasm of the breast, Neoplasm of the respiratory system, Neoplasm... ORPHA:2221
Multiple Endocrine Neoplasia, Type I
Peptic ulcer, Glucagonoma, Adenoma sebaceum, Adrenocortical adenoma, Pancreatic islet cell adenom... OMIM:131100
Monosomy 9Q22.3
Basal cell carcinoma, Rhabdomyosarcoma, Odontogenic keratocysts of the jaw, Ovarian fibroma, Card... ORPHA:77301
Asbestos Intoxication
Lung adenocarcinoma, Malignant mesothelioma ORPHA:2302
Disabling Pansclerotic Morphea Of Childhood
Squamous cell carcinoma of the skin OMIM:620443
Attenuated Familial Adenomatous Polyposis
Fibroma, Neoplasm of the stomach, Colorectal polyposis, Rectal polyposis, Adenocarcinoma of the c... ORPHA:220460
Premature Ovarian Failure 8
Streak ovary, Ovarian neoplasm, Elevated circulating luteinizing hormone level, Elevated circulat... OMIM:615723
Platelet Disorder, Undefined
Neuroblastoma, Hematological neoplasm OMIM:173420
Segmental Outgrowth-Lipomatosis-Arteriovenous Malformation-Epidermal Nevus Syndrome
Neoplasm of the thyroid gland, Ovarian neoplasm, Neoplasm of the breast, Visceral angiomatosis, H... ORPHA:137608
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Carcinoma, Primary hyperparathyroidism, Carcinoid tumor, Pituitary ad... OMIM:610755
Cushing Syndrome Due To Ectopic Acth Secretion
Neoplasm of the stomach, Neuroendocrine neoplasm, Small cell lung carcinoma, Pancreatic endocrine... ORPHA:99889
46,Xy Sex Reversal 10
Gonadal dysgenesis, Ovotestis, Hypospadias, Perineal hypospadias, Bifid scrotum, Decreased testic... OMIM:616425
Heart Defect-Tongue Hamartoma-Polysyndactyly Syndrome
Hamartoma of tongue, Benign neoplasm of the central nervous system, Cryptorchidism ORPHA:1338
Carney Triad
Leiomyosarcoma, Adrenocortical adenoma, Pheochromocytoma, Gastrointestinal stroma tumor, Paragang... ORPHA:139411
Thymic Neuroendocrine Tumor
Neoplasm of the endocrine system, Pancreatic islet cell adenoma, Neoplasm of the thymus, Primary ... ORPHA:97289
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 7
Portal hypertension, Cryptorchidism, Squamous cell carcinoma of the skin, Myelodysplasia OMIM:620365
Retinoblastoma
Rhabdomyosarcoma, Leiomyosarcoma, Retinoblastoma, Lymphoma, Ewing sarcoma, Melanoma, Glioma, Clef... ORPHA:790
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
46,Xy Sex Reversal 6
Gonadal dysgenesis, Clitoral hypertrophy, Hypospadias, Chordee, Sex reversal, Dysgerminoma, Gonad... OMIM:613762
Nijmegen Breakage Syndrome
Rhabdomyosarcoma, Anal stenosis, Lymphoma, Anal atresia, Glioma, Medulloblastoma, Cleft palate OMIM:251260
Lambert-Eaton Myasthenic Syndrome
Small cell lung carcinoma, Xerostomia ORPHA:43393
Multiple Endocrine Neoplasia Type 4
Pituitary growth hormone cell adenoma, Pituitary corticotropic cell adenoma, Pulmonary carcinoid ... ORPHA:276152
Gitelman Syndrome
Neoplasm of the pancreas, Parathyroid adenoma ORPHA:358
Werner Syndrome
Neoplasm of the oral cavity, Thyroid carcinoma, Renal neoplasm, Ovarian neoplasm, Aplasia/Hypopla... ORPHA:902
Cowden Syndrome 1
Carcinoma, Fibroadenoma of the breast, High palate, Furrowed tongue, Hamartomatous polyposis, Var... OMIM:158350
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:79434
Hirschsprung Disease-Ganglioneuroblastoma Syndrome
Ganglioneuroblastoma, Neoplasm of the nervous system, Aganglionic megacolon ORPHA:2151
Xeroderma Pigmentosum, Complementation Group C
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin, Actinic keratosis OMIM:278720
Neurofibromatosis Type 1
Rhabdomyosarcoma, Spinal neurofibroma, Pheochromocytoma, Neoplasm of the skin, Gastrointestinal s... ORPHA:636
Adrenocortical Carcinoma
Adrenocorticotropic hormone deficiency, Lung adenocarcinoma, Adrenocortical carcinoma ORPHA:1501
Xeroderma Pigmentosum, Complementation Group B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Hypogonadism, Neoplasm, Cutaneous mela... OMIM:610651
Pineoblastoma
Pinealoma, Retinoblastoma ORPHA:251909
Lhermitte-Duclos Disease
Neoplasm of the thyroid gland, Trichilemmoma, Ovarian neoplasm, Fibroadenoma of the breast, Macro... ORPHA:65285
Bohring-Opitz Syndrome
Annular pancreas, Cholelithiasis, Medulloblastoma, Cleft palate, Nephroblastoma ORPHA:97297
Common Variable Immunodeficiency
Elevated circulating hepatic transaminase concentration, Lymphoma, Anal atresia, Gastrointestinal... ORPHA:1572
Fanconi Anemia, Complementation Group S
Narrow palate, Ovarian carcinoma, Ovarian neoplasm, Breast carcinoma OMIM:617883
Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency
Focal pancreatic islet hyperplasia, Diffuse pancreatic islet hyperplasia, Elevated circulating gr... ORPHA:79644
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Dyskeratosis Congenita, Digenic
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma, Decreased testicular size, O... OMIM:620040
Xeroderma Pigmentosum, Complementation Group A
Squamous cell carcinoma of the skin, Melanoma OMIM:278700
Focal Cortical Dysplasia, Type Ii
Astrocytosis OMIM:607341
46,Xy Sex Reversal 7
Gonadal dysgenesis, male, Streak ovary, Abnormal epididymis morphology, Hypoplasia of the fallopi... OMIM:233420
Neuroendocrine Neoplasm Of Appendix
Hepatomegaly, Ovarian neoplasm, Elevated circulating hepatic transaminase concentration, Adrenoco... ORPHA:100079
Sporadic Creutzfeldt-Jakob Disease
Astrocytosis, Recurrent aspiration pneumonia, Gliosis ORPHA:204
Ectopic Aldosterone-Producing Tumor
Renal cortical adenoma, Ovarian neoplasm ORPHA:231632
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:220295
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6 concentration, Pancreatitis, Abnormal circulating interleukin... ORPHA:70578
Oligoarticular Juvenile Idiopathic Arthritis
Increased circulating interferon-gamma concentration, Knee osteoarthritis, Arthritis, Rheumatoid ... ORPHA:85410
Dyskeratosis Congenita, Autosomal Dominant 1
Cirrhosis, Squamous cell carcinoma of the skin, Hepatic necrosis, Oral leukoplakia, Myelodysplasia OMIM:127550
Pyomyositis
Testicular teratoma ORPHA:764
Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis
Arthritis, Symmetric polyarthritis, Abnormal circulating interleukin concentration, Synovitis ORPHA:85435
Oculocutaneous Albinism Type 2
Basal cell carcinoma, Squamous cell carcinoma of the skin, Cutaneous melanoma ORPHA:79432
Macrophage Activation Syndrome
Increased circulating interleukin 6 concentration, Increased circulating interferon-gamma concent... ORPHA:158061
Car T Cell Therapy-Associated Cytokine Release Syndrome
Abnormal circulating cytokine concentration, Increased circulating interleukin 6 concentration, I... ORPHA:542323
Dermatomyositis
Elevated circulating hepatic transaminase concentration, Lymphoma, Gastrointestinal stroma tumor,... ORPHA:221
Lmna-Related Cardiocutaneous Progeria Syndrome
Basal cell carcinoma, Squamous cell carcinoma of the skin, Pulmonary carcinoid tumor, Papillary r... ORPHA:363618
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12Rb1 Deficiency
Pneumonia, Salmonella osteomyelitis, Abnormal circulating interleukin concentration, Lymphadenitis ORPHA:319552
Progressive Non-Fluent Aphasia
Astrocytosis ORPHA:100070
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Spinal cord tumor, Narrow palate, Hypospadias, Pilomatrixoma, Intestinal malrotation, Meningioma,... ORPHA:353281
Sweet Syndrome
Panniculitis, Increased circulating interleukin 6 concentration, Myositis, Predominantly dermal n... ORPHA:3243
Sotos Syndrome
Aganglionic megacolon, Small cell lung carcinoma, Hypospadias, Phimosis, Cryptorchidism, Neurobla... ORPHA:821
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Astrocytosis OMIM:600795
Familial Infantile Bilateral Striatal Necrosis
Basal ganglia gliosis, Astrocytosis ORPHA:225154
Tetrasomy 9P
Jaundice, Biliary atresia, Pilomatrixoma, High palate, Oligozoospermia, Median cleft palate, Bifi... ORPHA:3310
Behavioral Variant Of Frontotemporal Dementia
Astrocytosis ORPHA:275864
Nmda Receptor Encephalitis
Testicular teratoma, Neoplasm of the lung, Ovarian teratoma, Neoplasm of the thymus, Neuroblastom... ORPHA:217253
Polyhydramnios, Megalencephaly, And Symptomatic Epilepsy
Astrocytosis OMIM:611087
Hermansky-Pudlak Syndrome
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79430
Autoimmune Lymphoproliferative Syndrome
Decreased specific anti-polysaccharide antibody level, Panniculitis, Gastritis, Recurrent aphthou... ORPHA:3261
Teratoma, Ovarian
Ovarian teratoma OMIM:166950
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Smooth tongue, Squamous cell carcinoma of the skin ORPHA:79396
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Narrow palate, Hypospadias, Pilomatrixoma, High palate, Intestinal malrotation, Meningioma, Crypt... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Narrow palate, Hypospadias, Pilomatrixoma, High palate, Intestinal malrotation, Meningioma, Crypt... ORPHA:353277
Inherited Creutzfeldt-Jakob Disease
Astrocytosis ORPHA:282166
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Abnormal circulating interferon-gamma concentration, Panhypogammaglobulinemia, Chronic mucocutane... ORPHA:79124
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Myositis, Lissencephaly, Astrocytosis, Pachygyria ORPHA:258
Intrahepatic Cholestasis Of Pregnancy
Abnormal circulating interleukin concentration, Cholecystitis ORPHA:69665
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Astrocytosis, Gliosis OMIM:203700
Cockayne Syndrome Type 3
Astrocytosis, Keratoconjunctivitis sicca ORPHA:90324
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Astrocytosis ORPHA:309854
Supranuclear Palsy, Progressive, 1
Astrocytosis, Gliosis OMIM:601104

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ndrg2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ndrg2.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Ndrg2em1(IMPC)Wtsi PMC7263671

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MGI Allele Allele Type Produced
Ndrg2em1(IMPC)Wtsi Deletion Mice
Ndrg2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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