Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Ntn3 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Pudendal Neuralgia | Paroxysmal rectal pain, Neuralgia, Pelvic pain, Vulvodynia, Allodynia, Scrotal pain, Anal pain | ORPHA:60039 | |
Trigeminal Neuralgia | Mandibular pain, Trigeminal neuralgia, Cranial nerve compression, Ocular pain, Allodynia | ORPHA:221091 | |
Complex Regional Pain Syndrome | Limb pain, Allodynia | ORPHA:83452 | |
Benign Schwannoma | Abnormality of the twelfth cranial nerve, Abnormal cranial nerve morphology, Abnormality of perip... | ORPHA:252164 | |
Anterior Cutaneous Nerve Entrapment Syndrome | Abdominal pain, Allodynia, Back pain | ORPHA:51890 | |
Neurotrophic Keratopathy | Abnormal fifth cranial nerve morphology, Allodynia | ORPHA:137596 | |
Spinal Cord Injury | Allodynia, Abnormal autonomic nervous system physiology | ORPHA:90058 | |
Mitochondrial Dna Depletion Syndrome 1 (Mngie Type) | Abdominal pain, Abdominal cramps, Allodynia | OMIM:603041 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ntn3.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Netrin-3 Suppresses Diabetic Neuropathic Pain by Gating the Intra-epidermal Sprouting of Sensory Axons. | Neuroscience bulletin (January 2023) | Ntn3tm1(KOMP)Mbp | 36587114 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Ntn3tm458144(Ifitm2_intron_L1L2_GT1_LF2A_LacZ_BetactP_neo) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Ntn3tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
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