Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
increased circulating chloride level | Rnf7tm1a(EUCOMM)Wtsi | HET | Early adult | 2.25×10-05 | ||
decreased circulating triglyceride level | Rnf7tm1a(EUCOMM)Wtsi | HET | Early adult | 1.04×10-05 | ||
abnormal response to tactile stimuli | Rnf7tm1a(EUCOMM)Wtsi | HET | Early adult | 2.25×10-06 | ||
abnormal gait | Rnf7tm1a(EUCOMM)Wtsi | HET | Early adult | 3.34×10-06 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Rnf7 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rnf7.
There are 4 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
CRL5-dependent regulation of the small GTPases ARL4C and ARF6 controls hippocampal morphogenesis. | Proceedings of the National Academy of Sciences of the United States of America (September 2020) | Rnf7tm1c(EUCOMM)Wtsi | 32873638 |
Comparative Analysis of cul5 and rbx2 Expression in the Developing and Adult Murine Brain and Their Essentiality During Mouse Embryogenesis. | Developmental dynamics : an official publication of the American Association of Anatomists (November 2018) | Rnf7tm1a(EUCOMM)Wtsi | 30269386 |
RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. | Development (Cambridge, England) (February 2018) | Rnf7tm1c(EUCOMM)Wtsi | 29361558 |
Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. | Developmental cell (November 2013) | Rnf7tm1c(EUCOMM)Wtsi Rnf7tm1a(EUCOMM)Wtsi | PMC3851519 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Rnf7tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
Rnf7tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Rnf7tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
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