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Genes Phenotypes Help, News, Blog

Gene: Sdcbp MGI:1337026

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
syndecan binding protein
Synonyms:
syndecan interacting protein,  syntenin,  syntenin-1,  Sycl,  MDA-9

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sdcbp mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sdcbp

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sdcbp.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis. Proceedings of the National Academy of Sciences of the United States of America (November 2023) Sdcbptm1d(KOMP)Wtsi 37922327
Knockout of MDA-9/Syntenin (SDCBP) expression in the microenvironment dampens tumor-supporting inflammation and inhibits melanoma metastasis. Oncotarget (July 2016) Sdcbptm1c(KOMP)Wtsi Sdcbptm1a(KOMP)Wtsi PMC5216907
Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex. Nature communications (April 2015) Sdcbptm1c(KOMP)Wtsi Sdcbptm1a(KOMP)Wtsi 25880340

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sdcbptm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sdcbptm35829(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Sdcbptm358022(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Sdcbptm35829(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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