Gene: Ap4e1

Order

Name adaptor-related protein complex AP-4, epsilon 1

Synonyms 2310033A20Rik

Status ES CellsMice
tm1a
Mice
tm1b
Mice
em1
Mice
em2
Mice
em1
Mice
tm1c
phenotype data available

Links MGI:1336993    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Ap4e1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ap4e1 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Bone marrow - depletion Ap4e1tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
Bone marrow - hypoplasia Ap4e1tm1a(KOMP)Wtsi HOM Male postnatal 0.0
Brain - process of degenerative change Ap4e1tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
Sternum - displacement and deformity Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 0.0
abnormal heart morphology Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 0.0
abnormal kidney morphology Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
abnormal seminal vesicle morphology Ap4e1em2(IMPC)Mbp HOM Male postnatal 0.0
abnormal spleen morphology Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
enlarged heart Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 0.0
enlarged lymph nodes Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
enlarged spleen Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 0.0
preweaning lethality, incomplete penetrance Ap4e1em1(IMPC)Bay HOM Female Male n/a 0.0
hyperactivity Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.23E-16
abnormal spine curvature Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.04E-15
kyphosis Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.04E-15
abnormal behavior Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.35E-13
decreased mean corpuscular hemoglobin Ap4e1tm1a(KOMP)Wtsi HOM Female Male postnatal 5.94E-12
abnormal sleep behavior Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.27E-11
decreased total body fat amount Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 6.67E-11
increased startle reflex Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 4.96E-10
decreased total retina thickness Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.03E-9
increased lean body mass Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.18E-9
abnormal lens morphology Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 4.52E-9
decreased total body fat amount Ap4e1em1(IMPC)J HOM Female Male postnatal 7.17E-9
increased prepulse inhibition Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.02E-8
decreased vertical activity Ap4e1em2(IMPC)Mbp HOM Female Male postnatal 2.35E-8
increased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 3.21E-8
increased fluid intake Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 5.65E-8
decreased cardiac stroke volume Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.36E-7
decreased cardiac output Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 4.16E-7
impaired glucose tolerance Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 4.4E-7
decreased circulating cholesterol level Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 5.29E-7
increased lean body mass Ap4e1em1(IMPC)J HOM Female Male postnatal 5.47E-7
decreased respiratory quotient Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 6.28E-7
abnormal sleep behavior Ap4e1em1(IMPC)J HET Female Male postnatal 6.39E-7
increased bone mineral content Ap4e1em1(IMPC)J HOM Female Male postnatal 9.28E-7
abnormal sensory capabilities/reflexes/nociception Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.13E-6
increased cardiac muscle contractility Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.51E-6
limb grasping Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.9E-6
abnormal sleep behavior Ap4e1em1(IMPC)J HOM Female Male postnatal 2.6E-6
abnormal behavioral response to light Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 3.01E-6
increased circulating alkaline phosphatase level Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 4.47E-6
increased heart weight Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 6.64E-6
increased or absent threshold for auditory brainstem response Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 7.6E-6
decreased grip strength Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 8.18E-6
decreased circulating insulin level Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 8.22E-6
decreased heart rate Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 1.0E-5
decreased circulating glucose level Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 1.07E-5
abnormal behavior Ap4e1tm1a(KOMP)Wtsi HOM Female Male postnatal 1.21E-5
decreased circulating triglyceride level Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.33E-5
hypoactivity Ap4e1em1(IMPC)J HOM Female Male postnatal 1.33E-5
long tibia Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 1.6E-5
short tibia Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 1.6E-5
decreased lean body mass Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 1.8E-5
decreased bone mineral content Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 2.22E-5
increased kidney weight Ap4e1tm1b(KOMP)Wtsi HOM Male postnatal 2.68E-5
decreased vertical activity Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 3.36E-5
decreased circulating HDL cholesterol level Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 3.4E-5
increased coping response Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 3.68E-5
decreased circulating insulin level Ap4e1em2(IMPC)Mbp HOM Female Male postnatal 3.75E-5
decreased circulating LDL cholesterol level Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 3.87E-5
increased lean body mass Ap4e1tm1a(KOMP)Wtsi HOM Male postnatal 4.48E-5
abnormal coat appearance Ap4e1em1(IMPC)Bay HET Male postnatal 4.55E-5
decreased heart weight Ap4e1tm1b(KOMP)Wtsi HOM Female postnatal 5.35E-5
abnormal bone structure Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 5.65E-5
increased erythrocyte cell number Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 6.05E-5
abnormal vitreous body morphology Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 6.51E-5
limb grasping Ap4e1em1(IMPC)J HOM Female postnatal 6.76E-5
abnormal retinal inner nuclear layer morphology Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 6.95E-5
abnormal heart left ventricle morphology Ap4e1tm1b(KOMP)Wtsi HOM Female Male postnatal 7.67E-5
abnormal femur morphology Ap4e1tm1a(KOMP)Wtsi HOM Male postnatal 8.12E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (4/4)
Adrenal gland 17 Yes (2/415) (11/19)
Aorta 21 Yes (10/23)
Blood 5 No
Blood vessel 4 No
Bone 14 Yes (3/16)
Bone marrow 7 No (2/7)
Brain 21 Yes (22/23)
Brainstem 21 No (16/23)
Brown adipose tissue 4 No
Brown adipose tissue 15 Yes (2/17)
Cartilage tissue 21 No (18/23)
Cecum 11 Yes (12/383) (8/13)
Cerebellum 21 No (19/23)
Cerebral cortex 21 No (16/23)
Chest bone 9 Yes (8/11)
Colon 9 No (12/127) (8/11)
Cranium 6 No
Diaphragm 9 Yes (6/11)
Duodenum 7 Yes (2/127) (7/9)
Epididymis 11 Yes (18/134) (2/13)
Esophagus 17 Yes (7/415) (12/19)
Eye 21 Yes (5/23)
Gall bladder 17 Yes (6/19)
Gonadal fat pad 7 Yes
Harderian gland 9 Yes
Heart 21 Yes (12/23)
Hindlimb 9 Yes (6/11)
Hippocampus 21 Yes (16/23)
Hypothalamus 21 No (16/23)
Ileum 7 Yes (14/127) (8/9)
Jejunum 7 Yes (6/127) (7/9)
Kidney 21 Yes (18/584) (23/23)
Large intestine 21 Yes (10/584) (12/23)
Liver 21 Yes (10/23)
Lower urinary tract 21 No (11/23)
Lung 21 Yes (14/23)
Lymph node 21 Yes (6/23)
Main olfactory bulb 6 Yes (6/8)
Mammary gland 21 Yes
Mesenteric lymph node 9 Yes
Mesenteric adipose tissue 7 Yes (2/9)
Midbrain 9 No (11/11)
Esophagus 4 No (2/4)
Olfactory lobe 17 No (17/19)
Olfactory lobe 4 No (2/4)
Oral epithelium 10 No (2/12)
Ovary 21 Yes (1/584) (9/23)
Oviduct 21 Yes (9/23)
Pancreas 21 Yes (5/584) (10/23)
Parathyroid gland 17 Yes (11/19)
Parotid gland 9 Yes
Penis 9 Yes (3/11)
Peripheral nervous system 21 No (8/23)
Peyer's patch 4 No
Peyer's patch 17 No (2/19)
Pituitary gland 21 Yes (21/23)
Prostate gland 21 Yes (12/584) (3/23)
Quadriceps 7 Yes (6/9)
Sciatic nerve 9 Yes
Skeletal muscle 17 No (16/19)
Skeletal muscle tissue 4 No (4/4)
Skin 21 Yes (18/23)
Small intestine 21 No (9/584) (12/23)
Spinal cord 21 Yes (23/23)
Spleen 21 Yes (2/584) (6/23)
Stomach 21 Yes (12/584) (15/23)
Stomach pyloric region 9 No
Striatum 21 No (16/23)
Sublingual gland 9 Yes
Submandibular gland 11 Yes (2/132) (2/13)
Testis 21 Yes (2/584) (11/23)
Thalamus 6 No (8/8)
Thymus 21 Yes (4/23)
Thyroid gland 21 Yes (15/584) (7/23)
Tongue 9 Yes (5/127) (6/11)
Trachea 21 Yes (18/23)
Trigeminal V nerve 11 Yes (9/13)
Urinary bladder 12 Yes (10/14)
Uterus 21 Yes (9/23)
Vagina 9 Yes
Vas deferens 11 No (15/388) (2/13)
Vascular system 17 No (4/19)
Vesicular gland 11 Yes (1/13)
White adipose tissue 21 Yes (2/23)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    limb
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system

LacZ Wholemount Images

  • exocrine system(13)
    Lower Urinary Tract expression
    Prostate gland expression
    MA:0002636
    MA:0000404
  • nervous system(151)
    Brain expression
    Hippocampus expression
    Cerebral Cortex expression
    Striatum expression
    MA:0000168
    MA:0000191
    MA:0000185
    MA:0000891

LacZ Section Images


 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 8 (6/485) (1/9)
Dorsal root ganglion 1 (1/47) Image Only
Ear 8 (1/485) (2/9)
Embryo 8 (1/485) (8/9)
Eye 8 (1/485) (8/9)
Foot 8 (1/485) (2/9)
Forearm 6 (1/282)
Forebrain 8 (1/485) (1/9)
Forelimb 8 (1/485) (2/9)
Fronto-nasal process 1 (1/48) Image Only
Hand 8 (1/485) (2/9)
Head 8 (5/485) (2/9)
Heart 8 (1/485) (1/9)
Hindbrain 8 (6/485) (1/9)
Hindlimb 8 (1/485) (2/9)
Liver 8 (1/485) (1/9)
Lower leg 6 (1/282)
Lung 8 (1/485)
Mandibular process 8 (1/485) (2/9)
Maxillary process 8 (1/485) (2/9)
Midbrain 8 (1/485) (1/9)
Nose 1 (1/51) (1/1)
Oral cavity 8 (1/485) (1/9)
Skin 8 (1/485) (2/9)
Spinal cord 1 (1/50) (1/1)
Tail 8 (1/485) (2/9)
Tail somite 8 (1/485) (1/9)
Upper arm 6 (1/282)
Upper leg 6 (1/282)
  • head(9)
    Eye expression
    EMAPA:16198 eye


Secondary lacZ Expression Data
postnatal mouse (32)
  • Ap4e1tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    stomach, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    tail skin, HET, Female, WTSI

show all 32 images

trunk (21)
  • Ap4e1tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    stomach, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI

show all 21 images

nervous system (6)
  • Ap4e1tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    brain, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    pituitary gland, peripheral nervous system, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    spinal cord, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    trigeminal V nerve, peripheral nervous system, HET, Female, WTSI

show all 6 images

digestive system (4)
  • Ap4e1tm1a(KOMP)Wtsi
    stomach, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    stomach, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    large intestine, HET, Male, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    gall bladder, HET, Female, WTSI
reproductive system (4)
  • Ap4e1tm1a(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    oviduct, ovary, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    ovary, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
endocrine system (3)
  • Ap4e1tm1a(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    parathyroid gland, HET, Male, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
respiratory system (3)
  • Ap4e1tm1a(KOMP)Wtsi
    trachea, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    lung, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    lung, HET, Male, WTSI
urinary system (3)
  • Ap4e1tm1a(KOMP)Wtsi
    kidney, HET, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    kidney, HET, Female, WTSI
cardiovascular system (2)
  • Ap4e1tm1a(KOMP)Wtsi
    heart, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    aorta, HET, Female, WTSI
immune system (2)
  • Ap4e1tm1a(KOMP)Wtsi
    lymph node, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    thymus, HET, Male, WTSI
integumental system (2)
  • Ap4e1tm1a(KOMP)Wtsi
    tail skin, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    skin, HET, Male, WTSI
musculoskeletal system (2)
  • Ap4e1tm1a(KOMP)Wtsi
    skeletal muscle tissue, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    cartilage tissue, rib, HET, Male, WTSI
set of connective tissues (2)
  • Ap4e1tm1a(KOMP)Wtsi
    cartilage tissue, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    cartilage tissue, rib, HET, Male, WTSI

Associated Images

Associated Images
  • Brain Histopathology: Hippocampal section
    3 Images
  • Brain Histopathology: Cerebellar Section
    3 Images
  • Brain Histopathology: Striatal Section
    3 Images
  • X-ray: XRay Images Forepaw
    33 Images
  • X-ray: XRay Images Dorso Ventral
    144 Images
  • X-ray: XRay Images Skull Lateral Orientation
    43 Images
  • X-ray: XRay Images Lateral Orientation
    122 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    53 Images
  • Embryo LacZ: LacZ images wholemount
    111 Images
  • Sleep Wake: Wake state (bmp file)
    29 Images
Legacy Phenotype Associated Images
Xray (198)
  • Ap4e1tm1a(KOMP)Wtsi
    head, HOM, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    body, HOM, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    body, HOM, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    body, WT, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    head, WT, Female, WTSI

show all 198 images

Brain Histopathology (12)
  • Ap4e1tm1a(KOMP)Wtsi
    corpus callosum, decreased corpus callosum size, HOM, Male, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    corpus callosum, decreased corpus callosum size, HOM, Male, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    corpus callosum, decreased corpus callosum size, HOM, Male, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    dereased mammillothalamic tract size, HOM, Male, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    anterior commissure, decreased anterior commissure size, HOM, Male, WTSI

show all 12 images

Histology Slide (5)
  • Ap4e1tm1b(KOMP)Wtsi
    TS20 hindlimb, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    TS20 hindbrain, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    TS20 skin, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    TS20 skin, HET, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    TS20 chorioallantoic placenta, HET, Female, WTSI
Eye Morphology (3)
  • Ap4e1tm1b(KOMP)Wtsi
    abnormal placement of pupils, abnormal pupil morphology, HOM, Female, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    cataracts, HOM, Male, WTSI
  • Ap4e1tm1b(KOMP)Wtsi
    cataracts, HOM, Male, WTSI
Skin Histopathology (3)
  • Ap4e1tm1a(KOMP)Wtsi
    back skin, HOM, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    back skin, WT, Female, WTSI
  • Ap4e1tm1a(KOMP)Wtsi
    back skin, WT, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Ap4e1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ap4e1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Ap4e1em1(IMPC)J Indel
Vector
Gene
Ap4e1em2(IMPC)Mbp Indel causing a Frameshift Mutation
Vector
Gene
Fixed Tissue
Ap4e1em1(IMPC)Bay Exon Deletion
Vector
Gene
Ap4e1tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene
Ap4e1tm35132(L1L2_Bact_P)
Vector
Gene