Gene: Dpm1

Order

Name dolichol-phosphate (beta-D) mannosyltransferase 1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1330239    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Dpm1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dpm1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Dpm1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
increased grip strength Dpm1tm1b(KOMP)Wtsi HET Female Male postnatal 4.6E-5
increased caudal vertebrae number Dpm1tm1b(KOMP)Wtsi HET Female Male postnatal 8.82E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (1/2)
Aorta 2 No
Blood vessel 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (1/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584)
Skeletal muscle tissue 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system digestive system nervous system reproductive system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (9)
  • Dpm1tm1b(KOMP)Wtsi
    pituitary gland, HET, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    large intestine, HET, Male, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    spinal cord, HET, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    parathyroid gland, HET, Male, WTSI

show all 9 images

trunk (6)
  • Dpm1tm1b(KOMP)Wtsi
    large intestine, HET, Male, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    spinal cord, HET, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    ovary, HET, Male, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI

show all 6 images

nervous system (3)
  • Dpm1tm1b(KOMP)Wtsi
    pituitary gland, HET, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    spinal cord, HET, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    brainstem, HET, Female, WTSI
endocrine system (2)
  • Dpm1tm1b(KOMP)Wtsi
    parathyroid gland, HET, Male, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    adrenal gland, HET, Female, WTSI
reproductive system (2)
  • Dpm1tm1b(KOMP)Wtsi
    testis, HET, Male, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    ovary, HET, Male, WTSI
digestive system (1)
  • Dpm1tm1b(KOMP)Wtsi
    large intestine, HET, Male, WTSI
urinary system (1)
  • Dpm1tm1b(KOMP)Wtsi
    kidney, HET, Male, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    15 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Dorso Ventral
    43 Images
  • Eye Morphology: Images Slit Lamp
    1 Images
  • Anti-nuclear antibody assay
    6 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (128)
  • Dpm1tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    WT, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    WT, Female, WTSI

show all 128 images

Histology Slide (2)
  • Dpm1tm1b(KOMP)Wtsi
    TS20 heart, HET, Female, WTSI
  • Dpm1tm1b(KOMP)Wtsi
    TS20 chorioallantoic placenta, HET, Female, WTSI
Dysmorphology (1)
  • Dpm1tm1b(KOMP)Wtsi
    tail, kinked tail, WT, Female, WTSI
Eye Morphology (1)
  • Dpm1tm1b(KOMP)Wtsi
    eyelids fail to open, HET, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dpm1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dpm1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene