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Gene: Gpr37 MGI:1313297

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
G protein-coupled receptor 37
Synonyms:
parkin-associated endothelin B-like receptor,  Pael-R

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Gpr37 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gpr37 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Joubert Syndrome 25
Molar tooth sign on MRI, Ataxia OMIM:616781
Joubert Syndrome 13
Molar tooth sign on MRI OMIM:614173
Joubert Syndrome 31
Molar tooth sign on MRI, Truncal ataxia OMIM:617761
Joubert Syndrome 4
Molar tooth sign on MRI, Elongated superior cerebellar peduncle, Ataxia, Thickened superior cereb... OMIM:609583
Meckel Syndrome 13
Molar tooth sign on MRI, Ataxia OMIM:617562
Joubert Syndrome 33
Molar tooth sign on MRI, Ataxia OMIM:617767
Joubert Syndrome 27
Molar tooth sign on MRI, Ataxia, Gait ataxia OMIM:617120
Joubert Syndrome 28
Molar tooth sign on MRI, Ataxia OMIM:617121
Joubert Syndrome 20
Molar tooth sign on MRI, Inability to walk OMIM:614970
Joubert Syndrome 15
Molar tooth sign on MRI, Ataxia OMIM:614464
Coach Syndrome 3
Molar tooth sign on MRI, Ataxia OMIM:619113
Joubert Syndrome 36
Molar tooth sign on MRI OMIM:618763
Adult Krabbe Disease
Broad-based gait, Abnormal medulla oblongata morphology, Ataxia, Abnormal midbrain morphology, So... ORPHA:206448
Joubert Syndrome 32
Molar tooth sign on MRI, Ataxia OMIM:617757
Joubert Syndrome 17
Molar tooth sign on MRI, Ataxia OMIM:614615
Joubert Syndrome 7
Molar tooth sign on MRI, Hypoplasia of the brainstem, Ataxia, Brainstem dysplasia OMIM:611560
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Paraganglioma of head and neck, Glomus tympan... OMIM:168000
Septopreoptic Holoprosencephaly
Abnormal midbrain morphology, Hypoplasia of the pons, Precocious puberty, Anterior hypopituitaris... ORPHA:280195
Pheochromocytoma/Paraganglioma Syndrome 3
Extraadrenal pheochromocytoma, Chemodectoma, Adrenal pheochromocytoma, Glomus jugular tumor, Para... OMIM:605373
Joubert Syndrome 6
Ataxia, Hypoplasia of the brainstem, Molar tooth sign on MRI, Elongated superior cerebellar pedun... OMIM:610688
Multiple Epiphyseal Dysplasia, Al-Gazali Type
Molar tooth sign on MRI ORPHA:166024
Progressive Supranuclear Palsy
Unsteady gait, Abnormal synaptic transmission, Bradykinesia, Falls, Neuronal loss in central nerv... ORPHA:683
Joubert Syndrome 35
Molar tooth sign on MRI, Elongated superior cerebellar peduncle, Ataxia OMIM:618161
Joubert Syndrome 10
Molar tooth sign on MRI OMIM:300804
Joubert Syndrome 3
Molar tooth sign on MRI, Elongated superior cerebellar peduncle, Ataxia OMIM:608629
Orofaciodigital Syndrome Xvi
Molar tooth sign on MRI, Inability to walk, Ataxia OMIM:617563
Joubert Syndrome 40
Molar tooth sign on MRI OMIM:619582
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Joubert Syndrome 8
Molar tooth sign on MRI, Ataxia OMIM:612291
Slc35A2-Cdg
Abnormal midbrain morphology, Precocious puberty, Inability to walk, Elevated circulating thyroid... ORPHA:356961
Orofaciodigital Syndrome Xv
Molar tooth sign on MRI OMIM:617127
Joubert Syndrome 16
Molar tooth sign on MRI OMIM:614465
Joubert Syndrome With Renal Defect
Molar tooth sign on MRI, Abnormality of the hypothalamus-pituitary axis, Ataxia, Gait disturbance ORPHA:220497
Joubert Syndrome With Ocular Defect
Molar tooth sign on MRI, Abnormality of the hypothalamus-pituitary axis, Ataxia, Gait disturbance ORPHA:220493
Joubert Syndrome With Oculorenal Defect
Molar tooth sign on MRI, Abnormality of the hypothalamus-pituitary axis, Ataxia ORPHA:2318
Joubert Syndrome 30
Molar tooth sign on MRI OMIM:617622
Joubert Syndrome 22
Molar tooth sign on MRI OMIM:615665
Joubert Syndrome 2
Ataxia, Brainstem dysplasia, Hypoplasia of the brainstem, Molar tooth sign on MRI, Elongated supe... OMIM:608091
Joubert Syndrome 9
Molar tooth sign on MRI OMIM:612285
Hydrolethalus Syndrome 2
Molar tooth sign on MRI OMIM:614120
Joubert Syndrome 14
Molar tooth sign on MRI, Hypoplasia of the brainstem, Ataxia OMIM:614424
Coach Syndrome 2
Molar tooth sign on MRI OMIM:619111
Joubert Syndrome 18
Molar tooth sign on MRI OMIM:614815
Amoebiasis Due To Free-Living Amoebae
Abnormal medulla oblongata morphology, Ataxia, Abnormal midbrain morphology, Abnormal brainstem M... ORPHA:68
Coach Syndrome 1
Molar tooth sign on MRI, Ataxia OMIM:216360
Al-Gazali-Bakalinova Syndrome
Molar tooth sign on MRI OMIM:607131
Joubert Syndrome 1
Ataxia, Brainstem dysplasia, Hypoplasia of the brainstem, Molar tooth sign on MRI, Elongated supe... OMIM:213300
Joubert Syndrome 38
Decreased serum insulin-like growth factor 1, Ectopic posterior pituitary, Decreased response to ... OMIM:619476
Japanese Encephalitis
Abnormal substantia nigra morphology, Abnormal midbrain morphology, Choreoathetosis, Abnormal pon... ORPHA:79139
Joubert Syndrome 37
Molar tooth sign on MRI OMIM:619185
Joubert Syndrome 39
Molar tooth sign on MRI, Pain insensitivity OMIM:619562
Meckel Syndrome, Type 10
Molar tooth sign on MRI OMIM:614175
Orofaciodigital Syndrome Type 6
Molar tooth sign on MRI, Ataxia, Gait disturbance ORPHA:2754
Joubert Syndrome 5
Molar tooth sign on MRI, Ataxia, Thickened superior cerebellar peduncle OMIM:610188
Arima Syndrome
Molar tooth sign on MRI, Hypoplasia of the brainstem, Ataxia, Brainstem dysplasia OMIM:243910
Cerebellar-Facial-Dental Syndrome
Hypoplasia of the pons, Hypoplasia of the brainstem, Abnormal midbrain morphology ORPHA:444072
Von Hippel-Lindau Disease
Pancreatic islet cell adenoma, Pancreatic endocrine tumor, Adrenal pheochromocytoma, Paragangliom... ORPHA:892
Meckel Syndrome, Type 4
Molar tooth sign on MRI OMIM:611134
Duplication Of The Pituitary Gland
Abnormal pituitary gland morphology, Abnormal midbrain morphology ORPHA:314621
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Abnormal midbrain morphology, Decreased response to growth hormone stimulation test, Central diab... ORPHA:293987
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia
Molar tooth sign on MRI, Hypoplasia of the brainstem OMIM:619306
Joubert Syndrome With Jeune Asphyxiating Thoracic Dystrophy
Molar tooth sign on MRI, Elongated superior cerebellar peduncle ORPHA:397715
Wilson Disease
Hypoparathyroidism, Hypoesthesia, Face of the giant panda sign OMIM:277900
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Molar tooth sign on MRI, Hypoplasia of the brainstem OMIM:616546
Orofaciodigital Syndrome Vi
Molar tooth sign on MRI OMIM:277170
Short-Rib Thoracic Dysplasia 13 With Or Without Polydactyly
Molar tooth sign on MRI OMIM:616300
Short-Rib Thoracic Dysplasia 21 Without Polydactyly
Molar tooth sign on MRI, Small pituitary gland OMIM:619479
Meckel Syndrome, Type 1
Molar tooth sign on MRI, Adrenal hypoplasia OMIM:249000
Orofaciodigital Syndrome Type 14
Molar tooth sign on MRI ORPHA:434179
Orofaciodigital Syndrome Xiv
Molar tooth sign on MRI OMIM:615948

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gpr37

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gpr37.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Metabolic Profiling of Mice with Deletion of the Orphan G Protein-Coupled Receptor, GPR37L1. Cells (June 2022) Gpr37l1tm1d(EUCOMM)Wtsi PMC9180194
Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications. International journal of molecular sciences (April 2022) Gpr37l1tm1a(EUCOMM)Wtsi Gpr37l1tm1b(EUCOMM)Wtsi Gpr37l1tm1d(EUCOMM)Wtsi PMC9025225
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner. Frontiers in pharmacology (January 2020) Gpr37l1tm1a(EUCOMM)Wtsi PMC7901490
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences (April 2018) Gpr37l1tm1c(EUCOMM)Wtsi Gpr37l1tm1a(EUCOMM)Wtsi PMC5889568

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MGI Allele Allele Type Produced
Gpr37tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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