Gene: Dlg4

Order

Name discs large MAGUK scaffold protein 4

Synonyms
  • PSD-95
  • SAP90A
  • SAP90
  • PSD95
  • Dlgh4

Status ES CellsMice
tm1e
phenotype data available

Links MGI:1277959    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Dlg4

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dlg4 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased CD4-positive, alpha beta T cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased CD8-positive, alpha-beta T cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased Ly6C high monocyte number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased Ly6C low monocyte number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased NK cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased T cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased alpha-beta T cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased effector memory CD4-positive, alpha-beta T cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased eosinophil cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased monocyte cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased neutrophil cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
increased B cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 0.0
decreased body weight Dlg4tm1Grnt HOM Female Male postnatal 1.4E-24
decreased exploration in new environment Dlg4tm1Grnt HOM Female Male postnatal 2.41E-20
decreased total body fat amount Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 9.35E-15
decreased grip strength Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 5.65E-12
increased lean body mass Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 2.13E-10
decreased circulating HDL cholesterol level Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 2.24E-10
increased circulating sodium level Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 3.74E-9
tremors Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 1.68E-8
abnormal behavior Dlg4tm1Grnt HOM Female Male postnatal 1.92E-7
increased bone mineral content Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 3.84E-7
hypoactivity Dlg4tm1Grnt HOM Female Male postnatal 7.29E-7
decreased NK T cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 3.6E-6
decreased bone mineral content Dlg4tm1Grnt HOM Female Male postnatal 4.88E-6
decreased total body fat amount Dlg4tm1Grnt HOM Male postnatal 7.11E-6
increased circulating phosphate level Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 8.56E-6
decreased circulating LDL cholesterol level Dlg4tm1e(EUCOMM)Wtsi HOM Male postnatal 9.7E-6
decreased effector memory CD8-positive, alpha-beta T cell number Dlg4tm1e(EUCOMM)Wtsi HOM Female Male postnatal 6.04E-5
decreased lean body mass Dlg4tm1e(EUCOMM)Wtsi HOM Male postnatal 6.28E-5

Download data as: TSV XLS



Expression

Secondary lacZ Expression Data
postnatal mouse (8)
  • Dlg4tm1Grnt
    brain, HET, Male, WTSI
  • Dlg4tm1Grnt
    pituitary gland, HET, Male, WTSI
  • Dlg4tm1Grnt
    adrenal gland, HET, Female, WTSI
  • Dlg4tm1Grnt
    large intestine, HET, Female, WTSI
  • Dlg4tm1Grnt
    stomach, HET, Female, WTSI

show all 8 images

nervous system (4)
  • Dlg4tm1Grnt
    brain, HET, Male, WTSI
  • Dlg4tm1Grnt
    pituitary gland, HET, Male, WTSI
  • Dlg4tm1Grnt
    brain, HET, Male, WTSI
  • Dlg4tm1Grnt
    spinal cord, HET, Male, WTSI
trunk (4)
  • Dlg4tm1Grnt
    adrenal gland, HET, Female, WTSI
  • Dlg4tm1Grnt
    large intestine, HET, Female, WTSI
  • Dlg4tm1Grnt
    stomach, HET, Female, WTSI
  • Dlg4tm1Grnt
    spinal cord, HET, Male, WTSI
digestive system (2)
  • Dlg4tm1Grnt
    large intestine, HET, Female, WTSI
  • Dlg4tm1Grnt
    stomach, HET, Female, WTSI
endocrine system (2)
  • Dlg4tm1Grnt
    adrenal gland, HET, Female, WTSI
  • Dlg4tm1Grnt
    thyroid gland, HET, Female, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    30 Images
  • X-ray: XRay Images Skull Lateral Orientation
    12 Images
  • X-ray: XRay Images Lateral Orientation
    25 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • Eye Morphology: Images Slit Lamp
    2 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Anti-nuclear antibody assay
    7 Images
  • DSS Histology
    8 Images
Legacy Phenotype Associated Images
Xray (263)
  • Dlg4tm1Grnt
    body, WT, Female, WTSI
  • Dlg4tm1Grnt
    head, WT, Female, WTSI
  • Dlg4tm1Grnt
    head, WT, Female, WTSI
  • Dlg4tm1Grnt
    body, HOM, Female, WTSI
  • Dlg4tm1Grnt
    forearm, HOM, Female, WTSI

show all 263 images

Skin Histopathology (3)
  • Dlg4tm1Grnt
    back skin, HOM, Female, WTSI
  • Dlg4tm1Grnt
    back skin, HOM, Female, WTSI
  • Dlg4tm1Grnt
    back skin, HOM, Female, WTSI
Tail Epidermis Wholemount (3)
  • Dlg4tm1Grnt
    abnormal sebaceous gland morphology, tail skin, HOM, Female, WTSI
  • Dlg4tm1Grnt
    tail skin, WT, Female, WTSI
  • Dlg4tm1Grnt
    tail skin, WT, Female, WTSI
Eye Morphology (2)
  • Dlg4tm1e(EUCOMM)Wtsi
    synechia, HOM, Female, WTSI
  • Dlg4tm1e(EUCOMM)Wtsi
    corneal opacity, HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dlg4tm1e(EUCOMM)Wtsi Targeted, non-conditional allele
Vector
Gene
Dlg4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene