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Gene: Utf1 MGI:1276125

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
undifferentiated embryonic cell transcription factor 1
Synonyms:
N/A

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Utf1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Utf1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Placental Insufficiency
Abnormal umbilical cord blood vessel morphology, Miscarriage, Proportionate short stature, Abnorm... ORPHA:439167
Lethal Congenital Contracture Syndrome 3
Neonatal death, Arthrogryposis multiplex congenita, Multiple joint contractures, Skeletal muscle ... OMIM:611369
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Short stature, Postnatal growth retardation, Osteoporosis, Severe postnatal growth retardation, S... ORPHA:73272
Nemaline Myopathy 10
Decreased fetal movement, Death in infancy, Skeletal muscle atrophy, Premature birth, Facial pals... OMIM:616165
Mitochondrial Complex I Deficiency, Nuclear Type 30
Neonatal death, Intrauterine growth retardation, Premature birth OMIM:301021
Silver-Russell Syndrome Due To A Point Mutation
Postnatal growth retardation, Intrauterine growth retardation, Small placenta, Oligohydramnios ORPHA:397590
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Ventricular septal defect, Diastasis recti, Polyhydramnios, Postnatal growth retardation, Large p... ORPHA:254534
Fetal Akinesia Deformation Sequence 1
Hip contracture, Decreased fetal movement, Decreased muscle mass, Premature birth, Elbow contract... OMIM:208150
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Joint laxity, Diastasis recti, Polyhydramnios, Postnatal growth retardation, Large placenta, Flex... ORPHA:254528
Arthrogryposis Multiplex Congenita 6
Decreased fetal movement, Death in infancy, Polyhydramnios, Increased variability in muscle fiber... OMIM:619334
Greenberg Dysplasia
Polyhydramnios, Multiple prenatal fractures, Patchy variation in bone mineral density, Hydrops fe... OMIM:215140
Restrictive Dermopathy
Osteopenia, Decreased fetal movement, Multiple joint contractures, Premature birth, Camptodactyly... ORPHA:1662
Neu-Laxova Syndrome 1
Decreased fetal movement, Ventricular septal defect, Spina bifida, Fetal akinesia sequence, Polyh... OMIM:256520
Cardiomyopathy, Dilated, 1Aa, With Or Without Left Ventricular Noncompaction
Myofiber disarray, Dilated cardiomyopathy, Death in adolescence, Cardiomyocyte hypertrophy, Endoc... OMIM:612158
Lethal Congenital Contracture Syndrome 1
Skeletal muscle atrophy, Hypoplasia of the musculature, Abnormality of the amniotic fluid, Neonat... OMIM:253310
Combined Oxidative Phosphorylation Deficiency 42
Death in infancy, Premature birth, Nonimmune hydrops fetalis, Cardiomyopathy, Neonatal death, Int... OMIM:618839
Combined Oxidative Phosphorylation Deficiency 40
Death in infancy, Premature birth, Nonimmune hydrops fetalis, Neonatal death, Intrauterine growth... OMIM:618835
Restrictive Dermopathy 1
Spontaneous chorioamniotic separation, Decreased fetal movement, Atrial septal defect, Limb joint... OMIM:275210
Mosaic Trisomy 16
Premature birth, Ventricular septal defect, Large placenta, Abnormal heart morphology, Single umb... ORPHA:1708
Kagami-Ogata Syndrome
Premature birth, Diastasis recti, Polyhydramnios, Postnatal growth retardation, Large placenta, L... ORPHA:254519
Trichohepatoenteric Syndrome 1
Short stature, Ventricular septal defect, Polyhydramnios, Large placenta, Abnormalities of placen... OMIM:222470
Ulnar Agenesis And Endocardial Fibroelastosis
Neonatal death, Hydrops fetalis, Endocardial fibroelastosis OMIM:276822
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Premature birth, Interphalangeal joint contracture of finger, Polyhydramnios, Short stature, Post... ORPHA:96334
Meacham Syndrome
Death in infancy, Atrial septal defect, Bicuspid aortic valve, Aplasia of the right hemidiaphragm... OMIM:608978
Meckel Syndrome, Type 1
Occipital encephalocele, Camptodactyly of finger, Breech presentation, Large placenta, Anencephal... OMIM:249000
Beckwith-Wiedemann Syndrome
Premature birth, Diastasis recti, Polyhydramnios, Congenital diaphragmatic hernia, Cardiomegaly, ... ORPHA:116
Homozygous Familial Hypercholesterolemia
Abnormal tendon morphology, Tendon xanthomatosis, Myocardial steatosis ORPHA:391665

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Utf1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Utf1.

No publications found that use IMPC mice or data for Utf1.

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MGI Allele Allele Type Produced
Utf1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells

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