Gene: Alox12e

Name arachidonate lipoxygenase, epidermal

Synonyms
  • Alox12-ps1
  • Aloxe
  • Alox12-ps2
  • e-LOX1
  • 8-LOX

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1274790   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Viable

Phenotype associations for Alox12e

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Alox12e data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased circulating insulin level Alox12etm1b(EUCOMM)Wtsi HOM Male postnatal 9.6E-7
decreased blood urea nitrogen level Alox12etm1b(EUCOMM)Wtsi HOM Female Male postnatal 6.15E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No
Aorta 2 No (1/562)
Blood vessel 2 No
Bone 2 No (1/539)
Brain 2 No (6/562)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Esophagus 2 No
Olfactory lobe 2 No
Ovary 2 No (1/562)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle tissue 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Testis 2 No (4/562)
Thymus 2 No (2/2)
Thyroid gland 2 No (16/562) (1/2)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse endocrine system reproductive system immune system integumental system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (2)
  • Alox12etm1b(EUCOMM)Wtsi
    THYMUS, HET, Female, WTSI
  • Alox12etm1b(EUCOMM)Wtsi
    OVIDUCT, HET, Female, WTSI
endocrine system (1)
  • Alox12etm1b(EUCOMM)Wtsi
    THYROID GLAND, HET, Male, WTSI
immune system (1)
  • Alox12etm1b(EUCOMM)Wtsi
    THYMUS, HET, Female, WTSI
integumental system (1)
  • Alox12etm1b(EUCOMM)Wtsi
    SKIN, HET, Female, WTSI
reproductive system (1)
  • Alox12etm1b(EUCOMM)Wtsi
    OVIDUCT, HET, Female, WTSI

Associated Images

Associated Images
  • DSS Histology
    8 Images
  • Anti-nuclear antibody assay
    6 Images
  • X-ray: XRay Images Dorso Ventral
    42 Images
  • X-ray: XRay Images Lateral Orientation
    28 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • Eye Morphology: Images Ophthalmoscopy
    1 Images
Legacy Phenotype Associated Images
Xray (70)
  • Alox12etm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Alox12etm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Alox12etm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Alox12etm1b(EUCOMM)Wtsi
    HOM, Female, WTSI
  • Alox12etm1b(EUCOMM)Wtsi
    HOM, Female, WTSI

show all 70 images

Eye Morphology (1)
  • Alox12etm1b(EUCOMM)Wtsi
    abnormal retinal pigmentation, HOM, Male, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Alox12etm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Alox12etm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Alox12etm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene