Gene: Axin2

Name axin 2

Synonyms
  • Conductin
  • Axil

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1270862   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Axin2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Axin2 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal body wall morphology Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal embryo development Axin2tm1b(KOMP)Wtsi HOM Male embryonic day 18.5 0.0
abnormal embryo size Axin2tm1b(KOMP)Wtsi HET Female Male embryonic day 18.5 0.0
abnormal embryo size Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal eyelid fusion Axin2tm1b(KOMP)Wtsi HOM Female embryonic day 18.5 0.0
abnormal facial morphology Axin2tm1b(KOMP)Wtsi HET Female embryonic day 18.5 0.0
abnormal facial morphology Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal head shape Axin2tm1b(KOMP)Wtsi HET Female embryonic day 18.5 0.0
abnormal head shape Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
abnormal limb morphology Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
anophthalmia Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
microphthalmia Axin2tm1b(KOMP)Wtsi HET Female embryonic day 18.5 0.0
microphthalmia Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
polydactyly Axin2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
preweaning lethality, complete penetrance Axin2tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
protruding tongue Axin2tm1b(KOMP)Wtsi HOM Female embryonic day 18.5 0.0
decreased body length Axin2tm1b(KOMP)Wtsi HET Female Male postnatal 5.02E-7
persistence of hyaloid vascular system Axin2tm1b(KOMP)Wtsi HET Male postnatal 5.58E-6
abnormal skin coloration Axin2tm1b(KOMP)Wtsi HET Female postnatal 2.57E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/562) (2/2)
Cecum 2 No (1/355)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562)
Gall bladder 2 No (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No (1/2)
Mesenteric lymph node 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393) (2/2)
Pituitary gland 2 No (1/562) (1/2)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vas deferens 2 No (1/360) (1/2)
Vascular system 2 No (1/393)
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system set of connective tissues
    reproductive system
    musculoskeletal system adipose tissue
    trunk
    postnatal mouse
    nervous system
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 (1/3) (2/2)
Axial skeleton 2 (1/5) (2/2)
Brain 2 (6/440) (2/2)
Central nervous system ganglion 2 (1/5) (2/2)
Cranium 2 Image Only (2/2)
Dorsal root ganglion 2 (1/3) (2/2)
Ear 2 (1/440) (2/2)
Embryo 2 (1/440) (2/2)
Outer ear 2 (2/2)
Eye 2 (1/440) (2/2)
Femur pre-cartilage condensation 2 Image Only (2/2)
Foot 2 (2/2)
Forearm 2 (2/2)
Forebrain 2 (1/440) (2/2)
Forelimb 2 (1/440) (2/2)
Fronto-nasal process 2 (1/4) (2/2)
Gut 2 (1/4) (2/2)
Hand 2 (2/2)
Head 2 (5/440) (2/2)
Head mesenchyme 2 (1/3) (2/2)
Heart 2 (1/440) (2/2)
Heart ventricle 2 (1/3) (2/2)
Hindbrain 2 (5/440) (2/2)
Hindlimb 2 (1/440) (2/2)
Humerus pre-cartilage condensation 2 Image Only (2/2)
Inner ear 2 Image Only (2/2)
Intestine 2 (2/2)
Liver 2 (1/440) (2/2)
Lower leg 2 (2/2)
Lung 2 (1/440) (2/2)
Mandibular process 2 (1/440) (2/2)
Maxillary process 2 (1/440) (2/2)
Mesonephros of female 2 Image Only (1/2)
Mesonephros of male 2 Image Only (1/2)
Metanephros 2 Image Only (2/2)
Midbrain 2 (1/440) (2/2)
Nasal septum 2 (2/2)
Nose 2 (1/5) (2/2)
Notochord 2 (2/2)
Oral cavity 2 (1/440) (2/2)
Outflow tract 2 (1/3) (2/2)
Pancreas 2 Image Only (2/2)
Pericardium 2 (1/2) (2/2)
Pharynx 2 Image Only (2/2)
Radius-ulna pre-cartilage condensation 2 Image Only (2/2)
Rib pre-cartilage condensation 2 (1/2) (2/2)
Skeleton 2 (1/5) (2/2)
Skin 2 (1/440) (2/2)
Spinal cord 2 (1/4) (2/2)
Stomach 2 Image Only (2/2)
Tail 2 (1/440) (2/2)
Tail somite 2 (1/440) (2/2)
Thoracic vertebral cartilage condensation 2 (1/2) (2/2)
Tongue 2 Image Only (2/2)
Trachea 2 Image Only (2/2)
Trunk mesenchyme 2 (1/3) (2/2)
Umbilical artery embryonic part 2 (2/2)
Umbilical vein embryonic part 2 (2/2)
Upper arm 2 (2/2)
Upper leg 2 (2/2)
Urinary system 2 Image Only (2/2)
Vibrissa 2 (2/2)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    9 Images
  • X-ray: XRay Images Lateral Orientation
    9 Images
  • X-ray: XRay Images Forepaw
    9 Images
  • X-ray: XRay Images Skull Lateral Orientation
    9 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    9 Images
  • Adult LacZ: LacZ Images Wholemount
    10 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Axin2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Axin2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene