Gene: Dnmt3a

Order

Name DNA methyltransferase 3A

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1261827    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable     Homozygous - Subviable

Phenotype associations for Dnmt3a

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dnmt3a data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Dnmt3atm1b(KOMP)Wtsi HOM Female embryonic day 12.5 0.0
preweaning lethality, incomplete penetrance Dnmt3atm1b(KOMP)Wtsi HOM Female Male n/a 0.0
increased grip strength Dnmt3atm1a(KOMP)Wtsi HOM Female Male postnatal 3.79E-12
decreased bone mineral content Dnmt3atm1b(KOMP)Wtsi HET Female postnatal 3.73E-9
increased bone mineral content Dnmt3atm1b(KOMP)Wtsi HET Male postnatal 3.73E-9
increased hemoglobin content Dnmt3atm1b(KOMP)Wtsi HET Female postnatal 1.08E-5
decreased circulating HDL cholesterol level Dnmt3atm1b(KOMP)Wtsi HET Male postnatal 3.22E-5
increased circulating HDL cholesterol level Dnmt3atm1b(KOMP)Wtsi HET Female postnatal 3.22E-5
increased total body fat amount Dnmt3atm1b(KOMP)Wtsi HET Female postnatal 3.79E-5
decreased effector memory CD8-positive, alpha-beta T cell number Dnmt3atm1a(KOMP)Wtsi HOM Male postnatal 8.9E-5
decreased lean body mass Dnmt3atm1b(KOMP)Wtsi HET Female postnatal 9.07E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Brain 2 No (6/562)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No (4/393)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Submandibular gland 2 No (1/104)
Testis 2 No (4/562) (1/2)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Urinary bladder 2 No
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    cardiovascular system
    reproductive system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482)
Dorsal root ganglion 2 (1/45)
Ear 2 (1/482)
Embryo 2 (1/482)
Eye 2 (1/482)
Foot 2 (1/482)
Forebrain 2 (1/482)
Forelimb 2 (1/482)
Fronto-nasal process 2 (1/46)
Hand 2 (1/482)
Head 2 (5/482)
Heart 2 (1/482)
Hindbrain 2 (6/482)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Midbrain 2 (1/482)
Nose 2 (1/47)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Spinal cord 2 (1/46)
Tail 2 (1/482)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    31 Images
  • X-ray: XRay Images Dorso Ventral
    60 Images
  • X-ray: XRay Images Lateral Orientation
    45 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    32 Images
  • Electroretinography: Rod waveform (pdf format)
    2 Images
  • X-ray: XRay Images Skull Lateral Orientation
    31 Images
  • Combined SHIRPA and Dysmorphology
    11 Images
  • Sleep Wake: Wake state (bmp file)
    11 Images
  • Eye Morphology: Images Slit Lamp
    3 Images
  • Electroretinography: Cone waveform (pdf format)
    2 Images
Legacy Phenotype Associated Images
Xray (86)
  • Dnmt3atm1a(KOMP)Wtsi
    WT, Female, WTSI
  • Dnmt3atm1a(KOMP)Wtsi
    WT, Female, WTSI
  • Dnmt3atm1a(KOMP)Wtsi
    HOM, Female, WTSI
  • Dnmt3atm1a(KOMP)Wtsi
    HOM, Female, WTSI
  • Dnmt3atm1a(KOMP)Wtsi
    HOM, Female, WTSI

show all 86 images

Eye Morphology (2)
  • Dnmt3atm1a(KOMP)Wtsi
    corneal opacity, HOM, Female, WTSI
  • Dnmt3atm1a(KOMP)Wtsi
    corneal vascularization, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dnmt3atm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dnmt3atm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene