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Gene: Myoc MGI:1202864

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
myocilin
Synonyms:
TIGR,  GLC1A

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Myoc mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Myoc by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Juvenile Glaucoma
Ocular hypertension ORPHA:98977
Glaucoma 1, Open Angle, A
OMIM:137750
Congenital Glaucoma
ORPHA:98976

The table below shows human diseases predicted to be associated to Myoc by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Glaucoma 1, Primary Open Angle, C
Ocular hypertension OMIM:601682
Glaucoma 1, Open Angle, F
Ocular hypertension OMIM:603383
Glaucoma 3, Primary Congenital, E
Ocular hypertension OMIM:617272
Glaucoma 3, Primary Congenital, A
Ocular hypertension OMIM:231300
Microphthalmia, Isolated 6
Ocular hypertension OMIM:613517
Microcoria, Congenital
Ocular hypertension OMIM:156600
Glaucoma, Primary Closed-Angle
Ocular hypertension OMIM:618880
Brachydactyly, Coloboma, And Anterior Segment Dysgenesis
Ocular hypertension OMIM:610023
Idiopathic Uveal Effusion Syndrome
Abnormal intraocular pressure ORPHA:209956
Irvan Syndrome
Ocular hypertension ORPHA:209943
Weill-Marchesani Syndrome 3
Ocular hypertension OMIM:614819
Neovascular Glaucoma
Ocular hypertension ORPHA:94058
Birdshot Chorioretinopathy
Ocular hypertension ORPHA:179
Anterior Segment Dysgenesis 1
Ocular hypertension OMIM:107250
Exfoliation Syndrome
Asymmetry of intraocular pressure OMIM:177650
Hyperostosis Cranialis Interna
Ocular hypertension OMIM:144755
Macrophthalmia, Colobomatous, With Microcornea
Ocular hypertension OMIM:602499
Anterior Segment Dysgenesis 7
Ocular hypertension OMIM:269400
Uveal Melanoma
Ocular hypertension ORPHA:39044
Weill-Marchesani Syndrome 4
Ocular hypertension OMIM:613195
1P31P32 Microdeletion Syndrome
Ocular hypertension ORPHA:401986
Craniofacial Anomalies And Anterior Segment Dysgenesis Syndrome
Ocular hypertension OMIM:614195
Juvenile Glaucoma
Ocular hypertension ORPHA:98977
Anterior Segment Dysgenesis 2
Ocular hypertension OMIM:610256
Idiopathic Panuveitis
Ocular hypertension ORPHA:280921
Wagro Syndrome
Ocular hypertension OMIM:612469
Dural Sinus Malformation
Ocular hypertension ORPHA:97339
Posterior Polymorphous Corneal Dystrophy
Ocular hypertension ORPHA:98973
Musculocontractural Ehlers-Danlos Syndrome
Ocular hypertension ORPHA:2953
Late-Onset Retinal Degeneration
Ocular hypertension ORPHA:67042
Congenital Microcoria
Ocular hypertension ORPHA:566
Fuchs Heterochromic Iridocyclitis
Ocular hypertension ORPHA:263479
Nail-Patella Syndrome
Ocular hypertension ORPHA:2614
Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
Ocular hypertension OMIM:610199
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Ocular hypertension ORPHA:93315
Facial Dysmorphism, Lens Dislocation, Anterior Segment Abnormalities, And Spontaneous Filtering Blebs
Ocular hypertension OMIM:601552
Oculoauricular Syndrome
Ocular hypertension OMIM:612109
Sympathetic Ophthalmia
Ocular hypertension ORPHA:79098
Phacoanaphylactic Uveitis
Ocular hypertension ORPHA:209959
Tubulointerstitial Nephritis And Uveitis Syndrome
Ocular hypertension ORPHA:91500
Glaucoma 1, Open Angle, A
OMIM:137750
Congenital Glaucoma
ORPHA:98976

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Myoc

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Myoc.

No publications found that use IMPC mice or data for Myoc.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Myoctm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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