Gene: Sept5

Name septin 5

Synonyms
  • Cdcrel1
  • Pnutl1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1195461   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Sept5

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Sept5 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Sept5tm1b(EUCOMM)Hmgu HOM Female Male n/a 0.0
small spleen Sept5tm1b(EUCOMM)Hmgu HET Female postnatal 0.0
prolonged ST segment Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 2.57E-11
thrombocytopenia Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 9.61E-11
prolonged QT interval Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 5.99E-10
cardiovascular system phenotype Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 1.31E-7
short tibia Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 2.3E-7
decreased bone mineral content Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 1.9E-5
improved glucose tolerance Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 1.98E-5
decreased body length Sept5tm1b(EUCOMM)Hmgu HET Female Male postnatal 5.5E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/354)
Aorta 4 No (2/530) (4/4)
Bone 4 No (1/515) (4/4)
Brain 4 No (8/530) (4/4)
Brainstem 4 No (5/530) (4/4)
Brown adipose tissue 4 No
Cartilage tissue 4 No (1/530) (4/4)
Cecum 4 No (1/325) (4/4)
Cerebellum 4 No (6/530) (4/4)
Cerebral cortex 4 No (6/530) (4/4)
Chest bone 4 No (4/4)
Colon 4 No (1/99) (4/4)
Cranium 4 No
Diaphragm 4 No
Duodenum 4 No (1/99) (4/4)
Epididymis 4 No (1/103)
Esophagus 4 No (1/354) (4/4)
Eye 4 No (1/530) (4/4)
Gall bladder 4 No
Gonadal fat pad 4 No
Harderian gland 4 No
Heart 4 No (4/530) (4/4)
Hindlimb 4 No (4/4)
Hippocampus 4 No (7/530) (4/4)
Hypothalamus 4 No (5/529) (4/4)
Ileum 4 No (1/99) (4/4)
Jejunum 4 No (1/99) (4/4)
Kidney 4 No (13/530) (4/4)
Large intestine 4 No (7/530) (4/4)
Liver 4 No
Lower urinary tract 4 No (3/530) (4/4)
Lung 4 No (4/530) (4/4)
Lymph node 4 No (2/530)
Main olfactory bulb 4 No (4/4)
Mammary gland 4 No
Mesenteric lymph node 4 No
Mesenteric adipose tissue 4 No
Midbrain 4 No (4/4)
Olfactory lobe 4 No (3/354) (4/4)
Oral epithelium 4 No (4/4)
Ovary 4 No (1/530)
Oviduct 4 No (1/530) (2/4)
Pancreas 4 No (2/530)
Parathyroid gland 4 No (2/516) (4/4)
Parotid gland 4 No
Penis 4 No (2/4)
Peripheral nervous system 4 No (4/530) (4/4)
Peyer's patch 4 No (1/354) (3/4)
Pituitary gland 4 No (2/530) (4/4)
Prostate gland 4 No (3/530)
Quadriceps 4 No
Sciatic nerve 4 No
Skeletal muscle 4 No
Skin 4 No (2/530) (4/4)
Small intestine 4 No (5/530) (4/4)
Spinal cord 4 No (5/530) (4/4)
Spleen 4 No (3/530)
Stomach 4 No (5/530) (4/4)
Stomach pyloric region 4 No
Striatum 4 No (6/530) (4/4)
Sublingual gland 4 No
Submandibular gland 4 No
Testis 4 No (7/530) (2/4)
Thalamus 4 No (4/4)
Thymus 4 No (1/530)
Thyroid gland 4 No (11/530)
Tongue 4 No (4/4)
Trachea 4 No (5/530) (4/4)
Trigeminal V nerve 4 No (4/4)
Urinary bladder 4 No (4/4)
Uterus 4 No (1/530)
Vagina 4 No (2/4)
Vas deferens 4 No (1/331)
Vascular system 4 No (1/354) (4/4)
Vesicular gland 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    limb
    endocrine system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 13 (5/413) (14/14)
Ear 13
Embryo 13 (14/14)
Eye 13 (8/14)
Foot 13
Forearm 13 (14/14)
Forebrain 13 (7/14)
Forelimb 13 (14/14)
Hand 13
Head 13 (4/413) (14/14)
Heart 13
Hindbrain 13 (5/413) (14/14)
Hindlimb 13 (8/14)
Liver 13
Lower leg 13 (8/14)
Lung 13
Mandibular process 13
Maxillary process 13
Midbrain 13 (1/14)
Oral cavity 13
Skin 13
Tail 13
Tail somite 13
Upper arm 13 (11/14)
Upper leg 13 (7/14)
  • alimentary system(9)
    Mandibular process ambiguous
    Maxillary process ambiguous
    EMAPA:17355 mandibular process
    EMAPA:17359 maxillary process
  • limb(19)
    Forelimb expression
    EMAPA:17412 forelimb


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    196 Images
  • Adult LacZ: LacZ Images Wholemount
    175 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Eye Morphology: Images Ophthalmoscopy
    1 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Sept5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Sept5tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene