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Gene: Mre11a MGI:1100512

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
MRE11A homolog A, double strand break repair nuclease
Synonyms:
N/A

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Mre11a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Mre11a by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ataxia-Telangiectasia-Like Disorder
Hypergonadotropic hypogonadism ORPHA:251347
Hereditary Breast And/Or Ovarian Cancer Syndrome
ORPHA:145
Ataxia-Telangiectasia-Like Disorder 1
OMIM:604391

The table below shows human diseases predicted to be associated to Mre11a by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Fraxf Syndrome
Folate-dependent fragile site at Xq28 ORPHA:100974
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Nijmegen Breakage Syndrome-Like Disorder
Chromosomal breakage induced by ionizing radiation OMIM:613078
Transcobalamin Deficiency
Lymphopenia, Abnormality of chromosome stability, Pancytopenia, Decreased circulating antibody le... ORPHA:859
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Abnormality of chromosome stability OMIM:600546
Scleroderma, Familial Progressive
Chromosome breakage, Abnormality of chromosome stability OMIM:181750
N Syndrome
Cryptorchidism, Abnormality of chromosome stability OMIM:310465
Fanconi Anemia, Complementation Group J
Chromosomal breakage induced by crosslinking agents OMIM:609054
Radial-Renal Syndrome
Chromosome breakage OMIM:179280
Fanconi Anemia, Complementation Group G
Abnormality of chromosome stability, Anemia, Neutropenia, Leukemia, Thrombocytopenia OMIM:614082
Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 2
Increased susceptibility to spontaneous sister chromatid exchange OMIM:618097
Fanconi Anemia, Complementation Group O
Chromosome breakage, Cryptorchidism OMIM:613390
Fanconi Anemia, Complementation Group T
Chromosomal breakage induced by crosslinking agents OMIM:616435
Fanconi Anemia, Complementation Group D1
Chromosomal breakage induced by crosslinking agents OMIM:605724
Fragile X Syndrome
Macroorchidism, postpubertal, Folate-dependent fragile site at Xq28, Congenital macroorchidism OMIM:300624
Immunodeficiency 54
Chromosome breakage OMIM:609981
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Macroorchidism, Folate-dependent fragile site at Xq28 ORPHA:85327
Fanconi Anemia, Complementation Group V
Chromosomal breakage induced by crosslinking agents OMIM:617243
Mitochondrial Complex Iv Deficiency, Nuclear Type 16
Chromosomal breakage induced by crosslinking agents OMIM:619060
Fragile X Syndrome
Macroorchidism, Folate-dependent fragile site at Xq28 ORPHA:908
Fanconi Anemia, Complementation Group U
Chromosome breakage, Patent ductus arteriosus OMIM:617247
Fanconi Anemia, Complementation Group Q
Chromosome breakage OMIM:615272
Fanconi Anemia, Complementation Group S
Chromosome breakage OMIM:617883
Fanconi Anemia, Complementation Group A
Male infertility, Hypergonadotropic hypogonadism, Cryptorchidism, Prolonged G2 phase of cell cycl... OMIM:227650
Fanconi Anemia, Complementation Group E
Hypergonadotropic hypogonadism, Cryptorchidism, Prolonged G2 phase of cell cycle, Deficient excis... OMIM:600901
Ataxia-Telangiectasia
Abnormality of chromosome stability, Abnormal testis morphology ORPHA:100
Fanconi Anemia, Complementation Group N
Chromosomal breakage induced by crosslinking agents OMIM:610832
Fanconi Anemia, Complementation Group R
Chromosomal breakage induced by crosslinking agents OMIM:617244
Fanconi Anemia, Complementation Group P
Cryptorchidism, Chromosomal breakage induced by crosslinking agents OMIM:613951
Bloom Syndrome
Chromosome breakage, Abnormality of chromosome stability, Decreased fertility in females, Cryptor... OMIM:210900
Fanconi Anemia, Complementation Group C
Hypergonadotropic hypogonadism, Cryptorchidism, Prolonged G2 phase of cell cycle, Deficient excis... OMIM:227645
Dyskeratosis Congenita, Autosomal Recessive 8
Chromosomal breakage induced by crosslinking agents OMIM:620133
Fanconi Anemia, Complementation Group I
Chromosomal breakage induced by crosslinking agents OMIM:609053
Icf Syndrome
Abnormality of chromosome stability, Abnormality of neutrophils, Decreased circulating antibody l... ORPHA:2268
Fanconi Anemia, Complementation Group B
Hypogonadism, Abnormality of chromosome stability, Patent ductus arteriosus, Hypergonadotropic hy... OMIM:300514
Bone Marrow Failure Syndrome 3
Chromosome breakage, Cryptorchidism OMIM:617052
Fanconi Anemia, Complementation Group F
Cryptorchidism, Patent ductus arteriosus, Chromosomal breakage induced by crosslinking agents OMIM:603467
Fanconi Anemia, Complementation Group D2
Hypergonadotropic hypogonadism, Cryptorchidism, Patent ductus arteriosus, Prolonged G2 phase of c... OMIM:227646
Fanconi Anemia, Complementation Group L
Chromosome breakage, Chromosomal breakage induced by crosslinking agents OMIM:614083
Lig4 Syndrome
Cryptorchidism, Abnormality of chromosome stability ORPHA:99812
Riddle Syndrome
Chromosomal breakage induced by ionizing radiation ORPHA:420741
Meningioma
Impotence, Chromosomal breakage induced by ionizing radiation, Hypogonadotropic hypogonadism, Ame... ORPHA:2495
Revesz Syndrome
Abnormality of chromosome stability OMIM:268130
Cartilage-Hair Hypoplasia
Decreased circulating antibody level, Abnormality of chromosome stability, Anemia, Neutropenia ORPHA:175
Fanconi Anemia
Abnormality of chromosome stability, Cryptorchidism, Patent ductus arteriosus, Azoospermia, Decre... ORPHA:84
Nijmegen Breakage Syndrome
Abnormality of chromosome stability ORPHA:647
Ataxia-Telangiectasia-Like Disorder
Hypergonadotropic hypogonadism ORPHA:251347
Hereditary Breast And/Or Ovarian Cancer Syndrome
ORPHA:145
Ataxia-Telangiectasia-Like Disorder 1
OMIM:604391

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Mre11a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Mre11a.

No publications found that use IMPC mice or data for Mre11a.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Mre11atm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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