Gene: Pitx3

Order

Name paired-like homeodomain transcription factor 3

Synonyms Ptx3

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:1100498    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Pitx3

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Pitx3 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
anophthalmia Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.54E-19
abnormal sleep behavior Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 2.27E-17
abnormal behavioral response to light Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 5.35E-12
increased coping response Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.41E-10
decreased vertical activity Pitx3eyl HOM Female postnatal 3.37E-9
increased grip strength Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 8.04E-9
decreased total body fat amount Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.9E-8
decreased lean body mass Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 7.98E-8
shortened ST segment Pitx3tm1.1(KOMP)Vlcg HOM Male postnatal 8.62E-8
increased exploration in new environment Pitx3eyl HOM Female postnatal 8.78E-8
increased fasted circulating glucose level Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 2.02E-7
decreased body weight Pitx3eyl HOM Female Male postnatal 4.23E-7
hypoactivity Pitx3eyl HOM Female postnatal 1.16E-6
abnormal bone structure Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.8E-6
decreased exploration in new environment Pitx3eyl HOM Female Male postnatal 4.18E-6
decreased circulating triglyceride level Pitx3eyl HOM Female Male postnatal 4.71E-6
decreased exploration in new environment Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 5.7E-6
increased circulating alkaline phosphatase level Pitx3eyl HOM Female Male postnatal 5.92E-6
decreased circulating amylase level Pitx3eyl HOM Female Male postnatal 1.9E-5
decreased bone mineral content Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 3.39E-5
abnormal social/conspecific interaction Pitx3eyl HOM Female postnatal 4.45E-5
increased heart rate Pitx3tm1.1(KOMP)Vlcg HOM Female Male postnatal 5.14E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No (2/2)
Cerebral cortex 2 No
Epididymis 2 No (18/134)
Esophagus 2 No (7/415)
Eye 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No (1/2)
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No (2/2)
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584) (1/2)
Stomach 2 No (12/584)
Striatum 2 No (2/2)
Submandibular gland 2 No (2/132) (1/2)
Testis 2 No (2/584) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (1/2)
Thyroid gland 2 No (15/584)
Trachea 2 No (1/2)
Urinary bladder 2 No
Uterus 2 No (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system digestive system cardiovascular system nervous system sensory organ reproductive system musculoskeletal system immune system exocrine system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2 (1/51) (1/2)
Brain 2 (6/485) (2/3)
Dorsal root ganglion 2 (1/47)
Ear 2 (1/485)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485) (2/3)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485) (2/3)
Fronto-nasal process 2 (1/48)
Hand 2 (1/485)
Head 2 (5/485) (2/3)
Heart 2 (1/485)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485) (2/3)
Liver 2 (1/485)
Lung 2 (1/485) Image Only
Mandibular process 2 (1/485) (2/3)
Maxillary process 2 (1/485)
Midbrain 2 (1/485) (2/3)
Nose 2 (1/51)
Oral cavity 2 (1/485) Image Only
Rib pre-cartilage condensation 1 (1/46) (1/1)
Skeleton 1 (1/51) Image Only
Skin 2 (1/485) Image Only
Spinal cord 2 (1/50)
Tail 2 (1/485) (2/3)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • Combined SHIRPA and Dysmorphology
    28 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Sleep Wake: Wake state (bmp file)
    9 Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Pitx3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Pitx3tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene