Gene: Itga8

Order

Name integrin alpha 8

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:109442    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Itga8

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Itga8 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Itga8tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased circulating glucose level Itga8tm1b(KOMP)Wtsi HET Female Male postnatal 2.77E-6
increased circulating triglyceride level Itga8tm1b(KOMP)Wtsi HET Female postnatal 1.32E-5
increased circulating calcium level Itga8tm1b(KOMP)Wtsi HET Female Male postnatal 3.2E-5
increased circulating sodium level Itga8tm1b(KOMP)Wtsi HET Female Male postnatal 3.47E-5
decreased bone mineral density Itga8tm1b(KOMP)Wtsi HET Male postnatal 6.3E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No (2/2)
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No (2/2)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415)
Eye 2 No
Heart 2 No
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No
Spleen 2 No (2/584) (2/2)
Stomach 2 No (12/584) (2/2)
Striatum 2 No
Submandibular gland 2 No (2/132)
Testis 2 No (2/584) (1/2)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Urinary bladder 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system digestive system cardiovascular system nervous system reproductive system immune system integumental system trunk urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (1/3)
Dorsal root ganglion 1 (1/47) Image Only
Ear 2 (1/485)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485)
Foot 2 (1/485) (2/3)
Forebrain 2 (1/485) (1/3)
Forelimb 2 (1/485) (2/3)
Fronto-nasal process 1 (1/48) Image Only
Gut 1 (1/50) (1/1)
Hand 2 (1/485) (2/3)
Head 2 (5/485) (2/3)
Heart 2 (1/485)
Hindbrain 2 (6/485) (1/3)
Hindlimb 2 (1/485) (2/3)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485) (2/3)
Maxillary process 2 (1/485) (2/3)
Midbrain 2 (1/485) (1/3)
Nose 2 (1/51) (2/2)
Oral cavity 2 (1/485) (1/3)
Rib pre-cartilage condensation 1 (1/46) (1/1)
Skin 2 (1/485) (2/3)
Spinal cord 1 (1/50) Image Only
Tail 2 (1/485)
Tail somite 2 (1/485)
Umbilical artery embryonic part 1 (1/47) (1/1)
Umbilical vein embryonic part 1 (1/47) (1/1)
Vibrissa 1 (1/47) (1/1)


Associated Images

Associated Images
  • X-ray: XRay Images Forepaw
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • Combined SHIRPA and Dysmorphology
    6 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Itga8tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Itga8tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Itga8tm39262(L1L2_Bact_P)
Vector
Gene
Itga8tm39262(L1L2_gt1)
Vector
Gene
Itga8tm39262(L1L2_Pgk_P)
Vector
Gene
Itga8tm39262(L1L2_Pgk_PM)
Vector
Gene