Gene: Mmp15

Order

Name matrix metallopeptidase 15

Synonyms
  • Membrane type 2-MMP
  • MT2-MMP

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:109320    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Mmp15

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mmp15 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal esophagus morphology Mmp15tm1b(KOMP)Wtsi HOM Male postnatal 0.0
abnormal pancreas morphology Mmp15tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
abnormal thyroid gland morphology Mmp15tm1b(KOMP)Wtsi HOM Male postnatal 0.0
abnormal trachea morphology Mmp15tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
absent lymph nodes Mmp15tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
anophthalmia Mmp15tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
athymia Mmp15tm1b(KOMP)Wtsi HOM Female Male postnatal 0.0
enlarged spleen Mmp15tm1b(KOMP)Wtsi HOM Female postnatal 0.0
abnormal skin coloration Mmp15tm1b(KOMP)Wtsi HOM Female postnatal 1.76E-6
decreased circulating alanine transaminase level Mmp15tm1b(KOMP)Wtsi HOM Female Male postnatal 8.64E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cecum 2 No (12/383)
Cerebellum 2 No
Cerebral cortex 2 No
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Heart 2 No (2/2)
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No
Olfactory lobe 2 No (2/2)
Oral epithelium 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584) (1/2)
Parathyroid gland 2 No
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No (2/2)
Testis 2 No (2/584)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No
Vas deferens 2 No (15/388)
Vascular system 2 No (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    cardiovascular system
    nervous system
    reproductive system
    exocrine system
    trunk
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Wholemount
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mmp15tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Mmp15tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene