Gene: Mapkapk2


Name MAP kinase-activated protein kinase 2

  • MK2
  • MAPKAP kinase 2
  • Rps6kc1

Status ES CellsMice
phenotype data available

Links MGI:109298    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Mapkapk2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mapkapk2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal bone structure Mapkapk2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 5.41E-9
decreased bone mineral content Mapkapk2tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.56E-7
increased circulating iron level Mapkapk2tm1b(EUCOMM)Hmgu HOM Male postnatal 1.13E-5
abnormal optic disk morphology Mapkapk2tm1b(EUCOMM)Hmgu HOM Male postnatal 1.18E-5
abnormal joint morphology Mapkapk2tm1b(EUCOMM)Hmgu HOM Male postnatal 1.39E-5
abnormal clavicle morphology Mapkapk2tm1b(EUCOMM)Hmgu HOM Male postnatal 4.17E-5

Download data as: TSV XLS


IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415) (3/4)
Aorta 4 No (4/4)
Bone 4 No
Brain 4 No (3/4)
Brainstem 4 No
Brown adipose tissue 4 No (4/4)
Cartilage tissue 4 No
Cerebellum 4 No
Cerebral cortex 4 No
Esophagus 4 No (7/415) (4/4)
Eye 4 No
Gall bladder 4 No (4/4)
Heart 4 No (4/4)
Hippocampus 4 No
Hypothalamus 4 No
Kidney 4 No (18/584) (4/4)
Large intestine 4 No (10/584) (3/4)
Liver 4 No
Lower urinary tract 4 No (4/4)
Lung 4 No (4/4)
Lymph node 4 No
Mammary gland 4 No
Olfactory lobe 4 No
Oral epithelium 4 No (1/4)
Ovary 4 No (1/584) (2/4)
Oviduct 4 No (2/4)
Pancreas 4 No (5/584)
Parathyroid gland 4 No (3/4)
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No
Prostate gland 4 No (12/584)
Skeletal muscle 4 No
Skin 4 No
Small intestine 4 No (9/584) (4/4)
Spinal cord 4 No
Spleen 4 No (2/584)
Stomach 4 No (12/584) (4/4)
Striatum 4 No
Testis 4 No (2/584) (2/4)
Thymus 4 No
Thyroid gland 4 No (15/584)
Trachea 4 No (1/4)
Uterus 4 No (2/4)
Vascular system 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    endocrine system
    digestive system
    cardiovascular system
    nervous system
    set of connective tissues
    reproductive system
    adipose tissue
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab

Associated Images

Associated Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • Adult LacZ: LacZ Images Wholemount
    15 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mapkapk2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Mapkapk2tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)