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Gene: Chrm5 MGI:109248

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cholinergic receptor, muscarinic 5
Synonyms:
muscarinic acetylcholine receptor 5,  M5R

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Chrm5 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Chrm5 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Hypertension, Paraganglioma OMIM:618464
Familial Cylindromatosis
Telangiectasia of the skin ORPHA:211
Moyamoya Disease 1
Inflammatory arteriopathy, Telangiectasia OMIM:252350
Pheochromocytoma/Paraganglioma Syndrome 3
Tachycardia, Extraadrenal pheochromocytoma, Glomus jugular tumor, Adrenal pheochromocytoma, Chemo... OMIM:605373
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Tachycardia, Extraadrenal pheochromocytoma, Paraganglioma of head and neck, ... OMIM:168000
Telangiectasia, Hereditary Benign
Diffuse telangiectasia OMIM:187260
Capillary Malformation-Arteriovenous Malformation 2
Telangiectasia OMIM:618196
Hereditary Central Diabetes Insipidus
Polydipsia, Vomiting, Diarrhea ORPHA:30925
Pure Autonomic Failure
Orthostatic hypotension, Syncope, Abnormality of circulating catecholamine level ORPHA:441
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Kleine-Levin Syndrome
Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, Hyperhid... ORPHA:33543
Central Diabetes Insipidus
Diarrhea, Polydipsia, Anorexia, Dehydration ORPHA:178029
Type 1 Diabetes Mellitus
Polydipsia, Polyphagia OMIM:222100
Telangiectasia, Hereditary Hemorrhagic, Type 5
Spontaneous, recurrent epistaxis, Portal hypertension, Telangiectasia OMIM:615506
Familial Cold Urticaria
Polydipsia, Dehydration, Hyperhidrosis ORPHA:47045
Acquired Central Diabetes Insipidus
Polydipsia ORPHA:95626
Huntington Disease
Aggressive behavior, Oral-pharyngeal dysphagia, Addictive alcohol use, Agitation, Compulsive beha... ORPHA:399
Intestinal Botulism
Diarrhea, Xerostomia, Dysphagia ORPHA:178481
Achalasia, Familial Esophageal
Achalasia, Xerostomia OMIM:200400
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Ochoa Syndrome
Polydipsia, Constipation, Bowel incontinence ORPHA:2704
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Polydipsia, Vomiting, Hypertonic dehydration, Constipation OMIM:125800
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia, Vomiting, Hypertonic dehydration, Constipation OMIM:304800
Helix Syndrome
Anhidrosis, Hyperparathyroidism, Xerostomia, Hypohidrosis, Polydipsia OMIM:617671
Familial Hyperaldosteronism Type I
Polydipsia, Dexamethasone-suppressible primary hyperaldosteronism, Nausea ORPHA:403
Iatrogenic Botulism
Constipation, Xerostomia, Dysphagia ORPHA:254509
Erythermalgia, Primary
Diarrhea, Constipation, Xerostomia, Hyperhidrosis OMIM:133020
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Pediatric-Onset Graves Disease
Hyperactivity, Thyrotoxicosis with diffuse goiter, Increased circulating free T3, Diarrhea, Grave... ORPHA:525731
Nephrogenic Diabetes Insipidus
Hypernatremic dehydration, Polyhydramnios, Anorexia, Constipation, Polydipsia ORPHA:223
Hyperaldosteronism, Familial, Type Iii
Polydipsia, Hyperaldosteronism OMIM:613677
Brain-Lung-Thyroid Syndrome
Hypoparathyroidism, Hyperactivity, Abnormal eating behavior, Abnormal drinking behavior, Congenit... ORPHA:209905
Familial Hyperaldosteronism Type Iii
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Dexamethasone-suppressible pri... ORPHA:251274
Botulism
Diarrhea, Constipation, Xerostomia, Dysphagia ORPHA:1267
Von Hippel-Lindau Disease
Pancreatic islet cell adenoma, Myocardial infarction, Myocarditis, Pancreatic endocrine tumor, Ad... ORPHA:892
Acute Lung Injury
Acute pancreatitis, Addictive alcohol use, Edema ORPHA:178320
Cystinosis
Abnormal repetitive mannerisms, Dehydration, Vomiting, Polydipsia, Hypothyroidism ORPHA:213
Methanol Poisoning
Diarrhea, Addictive alcohol use, Vomiting ORPHA:31825
Teratoma, Pineal
Polydipsia OMIM:273120
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Sjogren Syndrome
Xerostomia OMIM:270150
Foodborne Botulism
Diarrhea, Constipation, Xerostomia, Dysphagia ORPHA:228371
Marchiafava-Bignami Disease
Addictive alcohol use, Vomiting, Aggressive behavior ORPHA:221074
Infant Botulism
Bowel incontinence, Anorexia, Xerostomia, Constipation, Dysphagia ORPHA:178478
Panhypophysitis
Decreased circulating cortisol level, Reduced circulating prolactin concentration, Hashimoto thyr... ORPHA:95513
Primary Unilateral Adrenal Hyperplasia
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Nausea ORPHA:231580
Secondary Non-Traumatic Avascular Necrosis
Addictive alcohol use ORPHA:399180
Postorgasmic Illness Syndrome
Xerostomia, Hyperhidrosis ORPHA:279947
East Syndrome
Polydipsia, Salt craving, Hyperaldosteronism ORPHA:199343
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Anorexia, Diarrhea, Xerostomia, Hematochezia, Vomiting OMIM:175500
Acquired Aneurysmal Subarachnoid Hemorrhage
Addictive alcohol use, Vomiting, Hypopituitarism, Hypothyroidism, Nausea ORPHA:90065
Inhalational Botulism
Diarrhea, Xerostomia, Constipation ORPHA:254504
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Polydipsia, Hyperaldosteronism, Dexamethasone-suppressible primary hyperaldosteronism, Nausea ORPHA:369929
Herpes Simplex Virus Encephalitis
Addictive alcohol use, Cerebral edema ORPHA:1930
Whipple Disease
Gastrointestinal hemorrhage, Anorexia, Diarrhea, Pedal edema, Polydipsia, Hypothyroidism ORPHA:3452
Reynolds Syndrome
Gastroesophageal reflux, Ascites, Xerostomia, Dysphagia ORPHA:779
Pituitary Dermoid And Epidermoid Cysts
Panhypopituitarism, Hyperpituitarism, Polydipsia, Anterior hypopituitarism, Increased circulating... ORPHA:91351
Staphylococcal Necrotizing Pneumonia
Pleural effusion, Addictive alcohol use, Pleural empyema ORPHA:36238
Adiposis Dolorosa
Hypothyroidism, Constipation, Xerostomia, Diarrhea ORPHA:36397
Amyotrophic Lateral Sclerosis
Xerostomia, Agitation ORPHA:803
Septo-Optic Dysplasia Spectrum
Polydipsia, Constipation, Hypohidrosis ORPHA:3157
Prune Belly Syndrome
Xerostomia, Oligohydramnios OMIM:100100
Nephronophthisis 4
Polydipsia OMIM:606966
Apparent Mineralocorticoid Excess
Polydipsia, Decreased circulating aldosterone level ORPHA:320
Cirrhotic Cardiomyopathy
Peripheral edema, Ascites, Addictive alcohol use, Pulmonary edema ORPHA:57777
Isolated Osteopoikilosis
Addictive alcohol use ORPHA:166119
Antisynthetase Syndrome
Xerostomia, Edema, Dysphagia ORPHA:81
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Renal Hypoplasia
Polydipsia, Dehydration ORPHA:93101
Acute Promyelocytic Leukemia
Stomatitis, Addictive alcohol use, Anorexia ORPHA:520
Hyperparathyroidism, Neonatal Severe
Polydipsia, Primary hyperparathyroidism, Constipation OMIM:239200
Bardet-Biedl Syndrome 17
Polydipsia OMIM:615994
Diffuse Cutaneous Systemic Sclerosis
Gastroesophageal reflux, Xerostomia, Dysphagia ORPHA:220393
Nephronophthisis 3
Polydipsia OMIM:604387
Aplasia Of Lacrimal And Salivary Glands
Xerostomia OMIM:180920
Senior-Boichis Syndrome
Aggressive behavior, Agitation, Attention deficit hyperactivity disorder, Polydipsia, Ascites ORPHA:84081
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Salt craving, Hyperaldosteronism OMIM:612780
Nephronophthisis 1
Polydipsia OMIM:256100
Infantile Nephropathic Cystinosis
Abnormality of thyroid physiology, Dehydration, Vomiting, Constipation, Polydipsia ORPHA:411629
Ethylene Glycol Poisoning
Gastritis, Addictive alcohol use, Vomiting, Nausea, Cerebral edema, Pulmonary edema ORPHA:31826
Gitelman Syndrome
Polydipsia, Salt craving, Vomiting, Constipation OMIM:263800
Nephronophthisis 11
Polydipsia OMIM:613550
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polyhydramnios, Edema, Hydrops fetalis, Hyperaldosteronism, Polydipsia OMIM:602522
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Abnormality of exocrine pancreas physiology, Abnormality of endocrine pancreas physiology, Polydi... ORPHA:93111
Oligomeganephronia
Polydipsia, Dehydration ORPHA:2260
Lambert-Eaton Myasthenic Syndrome
Constipation, Xerostomia, Hypohidrosis ORPHA:43393
Erdheim-Chester Disease
Pleural effusion, Polydipsia, Joint swelling, Hyperhidrosis ORPHA:35687
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Decreased response to growth hormone stimulation test, Aggressive behavior, Adrenocorticotropic h... ORPHA:293987
Distal Renal Tubular Acidosis
Diarrhea, Dehydration, Vomiting, Constipation, Polydipsia ORPHA:18
Toxic Epidermal Necrolysis
Gastrointestinal hemorrhage, Polydipsia, Pancreatitis, Dysphagia ORPHA:537
Hyperparathyroidism-Jaw Tumor Syndrome
Primary hyperparathyroidism, Constipation, Dysphagia, Polydipsia, Pancreatitis ORPHA:99880
Parathyroid Carcinoma
Primary hyperparathyroidism, Constipation, Dysphagia, Polydipsia, Pancreatitis ORPHA:143
Gitelman Syndrome
Salt craving, Pericardial effusion, Diarrhea, Hyperhidrosis, Constipation, Primary hyperaldostero... ORPHA:358
Juvenile Nephropathic Cystinosis
Hypothyroidism, Polydipsia, Vomiting, Dehydration ORPHA:411634
Wolfram Syndrome
Gastrointestinal hemorrhage, Polydipsia, Constipation ORPHA:3463
Rabson-Mendenhall Syndrome
Polydipsia, Hypothyroidism ORPHA:769
Cystinosis, Nephropathic
Oral-pharyngeal dysphagia, Dehydration, Hypohidrosis, Primary hypothyroidism, Dysphagia, Polydips... OMIM:219800
Porphyria Cutanea Tarda
Addictive alcohol use ORPHA:101330
Bartter Syndrome, Type 2, Antenatal
Polyhydramnios, Diarrhea, Dehydration, Hyperaldosteronism, Vomiting, Constipation, Polydipsia OMIM:241200
Proximal Renal Tubular Acidosis
Diarrhea, Polydipsia, Vomiting, Dehydration ORPHA:47159
Hypomagnesemia 3, Renal
Polydipsia OMIM:248250
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Polydipsia, Ascites, Oligohydramnios ORPHA:731
Arima Syndrome
Polydipsia OMIM:243910

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Chrm5

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chrm5.

No publications found that use IMPC mice or data for Chrm5.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Chrm5tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Chrm5tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Chrm5tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Chrm5tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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