Gene: Fzd5 MGI:108571
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal heart morphology | Fzd5tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
enlarged heart | Fzd5tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
small superior vagus ganglion | Fzd5tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
hydrometra | Fzd5tm1.1(KOMP)Vlcg | HET | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Fzd5tm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 100% (1 of 1) |
Aorta | Section images | heterozygote | 100% (1 of 1) |
Bone marrow | Section images | heterozygote | 100% (1 of 1) |
Cecum | Section images | heterozygote | 100% (1 of 1) |
Cerebellum | Section images | heterozygote | 100% (1 of 1) |
Colon | Section images | heterozygote | 100% (1 of 1) |
Duodenum | Section images | heterozygote | 100% (1 of 1) |
Epididymis | Section images | heterozygote | 100% (1 of 1) |
Esophagus | Section images | heterozygote | 100% (1 of 1) |
Eye | Section images | heterozygote | 100% (1 of 1) |
Harderian gland | Section images | heterozygote | 100% (1 of 1) |
Ileum | Section images | heterozygote | 100% (1 of 1) |
Jejunum | Section images | heterozygote | 100% (1 of 1) |
Kidney | Section images | heterozygote | 100% (1 of 1) |
Lung | Section images | heterozygote | 100% (1 of 1) |
Midbrain | Section images | heterozygote | 100% (1 of 1) |
Olfactory lobe | Section images | heterozygote | 100% (1 of 1) |
Pancreas | Section images | heterozygote | 100% (1 of 1) |
Parotid gland | Section images | heterozygote | 100% (1 of 1) |
Penis | Section images | heterozygote | 100% (1 of 1) |
Pituitary gland | Section images | heterozygote | 100% (1 of 1) |
Quadriceps | Section images | heterozygote | 100% (1 of 1) |
Skin | Section images | heterozygote | 100% (1 of 1) |
Spinal cord | Section images | heterozygote | 0.0% (0 of 1) |
Spleen | Section images | heterozygote | 100% (1 of 1) |
Stomach | Section images | heterozygote | 100% (1 of 1) |
Sublingual gland | Section images | heterozygote | 100% (1 of 1) |
Submandibular gland | Section images | heterozygote | 100% (1 of 1) |
Testis | Section images | heterozygote | 100% (1 of 1) |
Thyroid gland | Section images | heterozygote | 100% (1 of 1) |
Tongue | Section images | heterozygote | 100% (1 of 1) |
Trachea | Section images | heterozygote | 100% (1 of 1) |
Urinary bladder | Section images | heterozygote | 100% (1 of 1) |
Vesicular gland | Section images | heterozygote | 100% (1 of 1) |
Blood | N/A | heterozygote | 0.0% (0 of 1) |
Brain | N/A | heterozygote | 100% (1 of 1) |
Brainstem | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 1) |
Cartilage tissue | N/A | heterozygote | Not available |
Cerebral cortex | N/A | heterozygote | Not available |
Chest bone | N/A | heterozygote | Not available |
Diaphragm | N/A | heterozygote | 0.0% (0 of 1) |
Gall bladder | N/A | heterozygote | Not available |
Gonadal fat pad | N/A | heterozygote | 0.0% (0 of 1) |
Heart | N/A | heterozygote | Not available |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | Not available |
Hypothalamus | N/A | heterozygote | Not available |
Large intestine | N/A | heterozygote | 100% (1 of 1) |
Liver | N/A | heterozygote | 0.0% (0 of 1) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | Not available |
Mammary gland | N/A | heterozygote | Not available |
Mesenteric adipose tissue | N/A | heterozygote | 0.0% (0 of 1) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 1) |
Ovary | N/A | heterozygote | Not available |
Oviduct | N/A | heterozygote | Not available |
Parathyroid gland | N/A | heterozygote | 0.0% (0 of 1) |
Peripheral nervous system | N/A | heterozygote | Not available |
Peyer's patch | N/A | heterozygote | Not available |
Prostate gland | N/A | heterozygote | Not available |
Sciatic nerve | N/A | heterozygote | 0.0% (0 of 1) |
Skeletal muscle | N/A | heterozygote | Not available |
Small intestine | N/A | heterozygote | 100% (1 of 1) |
Stomach pyloric region | N/A | heterozygote | Not available |
Striatum | N/A | heterozygote | Not available |
Thymus | N/A | heterozygote | 0.0% (0 of 1) |
Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 1) |
Uterus | N/A | heterozygote | Not available |
Vagina | N/A | heterozygote | Not available |
Vas deferens | N/A | heterozygote | Not available |
Vascular system | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | Not available |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Axial skeleton | N/A | heterozygote | 85.71% (6 of 7) |
Brain | N/A | heterozygote | 100% (7 of 7) |
Central nervous system ganglion | N/A | heterozygote | 100% (7 of 7) |
Dorsal root ganglion | N/A | heterozygote | 0.0% (0 of 7) |
Ear | N/A | heterozygote | 28.57% (2 of 7) |
Embryo | N/A | heterozygote | 100% (7 of 7) |
Eye | N/A | heterozygote | 100% (7 of 7) |
Footplate | N/A | heterozygote | 0.0% (0 of 7) |
Forebrain | N/A | heterozygote | 100% (7 of 7) |
Forelimb | N/A | heterozygote | 100% (7 of 7) |
Fronto-nasal process | N/A | heterozygote | 0.0% (0 of 7) |
Gut | N/A | heterozygote | 66.67% (2 of 3) |
Handplate | N/A | heterozygote | 0.0% (0 of 7) |
Head mesenchyme | N/A | heterozygote | 0.0% (0 of 7) |
Head | N/A | heterozygote | 14.29% (1 of 7) |
Heart | N/A | heterozygote | 0.0% (0 of 7) |
Hindbrain | N/A | heterozygote | 0.0% (0 of 7) |
Hindlimb | N/A | heterozygote | 100% (7 of 7) |
Intestine | N/A | heterozygote | 66.67% (2 of 3) |
Liver | N/A | heterozygote | 0.0% (0 of 7) |
Lung | N/A | heterozygote | 0.0% (0 of 7) |
Mandibular process | N/A | heterozygote | 0.0% (0 of 7) |
Maxillary process | N/A | heterozygote | 14.29% (1 of 7) |
Meckel's cartilage | N/A | heterozygote | 71.43% (5 of 7) |
Metanephros | N/A | heterozygote | 50% (3 of 6) |
Midbrain | N/A | heterozygote | 0.0% (0 of 7) |
Nasal septum | N/A | heterozygote | 0.0% (0 of 7) |
Nose | N/A | heterozygote | 0.0% (0 of 7) |
Notochord | N/A | heterozygote | 85.71% (6 of 7) |
Oral cavity | N/A | heterozygote | 85.71% (6 of 7) |
Pharynx | N/A | heterozygote | 50% (3 of 6) |
Rib pre-cartilage condensation | N/A | heterozygote | 0.0% (0 of 7) |
Skeleton | N/A | heterozygote | 100% (7 of 7) |
Skin | N/A | heterozygote | 0.0% (0 of 7) |
Spinal cord | N/A | heterozygote | 0.0% (0 of 7) |
Tail somite | N/A | heterozygote | 14.29% (1 of 7) |
Tail | N/A | heterozygote | 14.29% (1 of 7) |
Thoracic vertebral cartilage condensation | N/A | heterozygote | 100% (7 of 7) |
Tongue | N/A | heterozygote | 0.0% (0 of 5) |
Trunk mesenchyme | N/A | heterozygote | 0.0% (0 of 7) |
Umbilical artery embryonic part | N/A | heterozygote | 100% (4 of 4) |
Umbilical vein embryonic part | N/A | heterozygote | 100% (2 of 2) |
Vibrissa | N/A | heterozygote | 85.71% (6 of 7) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood | |
bone marrow | |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
chest bone | |
colon | |
diaphragm | 0.0% |
duodenum | 0.0% |
epididymis | Unavailable |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | |
heart | 0.0% |
hindlimb | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
ileum | 0.0% |
jejunum | |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | |
midbrain | 0.0% |
olfactory lobe | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.0% |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
stomach pyloric region | 0.0% |
striatum | 0.0% |
sublingual gland | 0.0% |
submandibular gland | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
tongue | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vagina | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
vesicular gland | Unavailable |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
axial skeleton | Ambiguous |
brain | 0.0% |
central nervous system ganglion | Ambiguous |
dorsal root ganglion | Ambiguous |
ear | 0.0% |
embryo | 0.0% |
eye | 0.0% |
footplate | 0.0% |
forebrain | 0.0% |
forelimb | 0.0% |
fronto-nasal process | Ambiguous |
gut | Ambiguous |
handplate | 0.0% |
head | 0.0% |
head mesenchyme | Ambiguous |
heart | 0.0% |
hindbrain | 0.0% |
hindlimb | 0.0% |
intestine | Ambiguous |
liver | 0.0% |
lung | 0.0% |
mandibular process | 0.0% |
maxillary process | 0.0% |
meckel's cartilage | Ambiguous |
metanephros | Ambiguous |
midbrain | 0.0% |
nasal septum | Ambiguous |
nose | Ambiguous |
notochord | Ambiguous |
oral cavity | 0.0% |
pharynx | Ambiguous |
rib pre-cartilage condensation | Ambiguous |
skeleton | Ambiguous |
skin | 0.0% |
spinal cord | Ambiguous |
tail | 0.0% |
tail somite group | 0.0% |
thoracic vertebral cartilage condensation | Ambiguous |
tongue | Ambiguous |
trunk mesenchyme | Ambiguous |
umbilical artery embryonic part | Ambiguous |
umbilical vein embryonic part | Ambiguous |
vibrissa | Ambiguous |
Human diseases caused by Fzd5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Fzd5 by phenotypic similarity.
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fzd5.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways. | Disease models & mechanisms (March 2023) | Fzd5tm1.1(KOMP)Vlcg | PMC10073008 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Fzd5tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Fzd5tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
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