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Gene: Irak1 MGI:107420

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Gene Summary

Name:
interleukin-1 receptor-associated kinase 1
Synonyms:
Il1rak,  mPLK,  Plpk,  IRAK-1

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating fructosamine level Irak1tm1b(EUCOMM)Hmgu HEM Early adult 7.47×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

14 Images

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X-ray

XRay Images Whole Body Lateral Orientation

14 Images

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X-ray

XRay Images Skull Lateral Orientation

14 Images

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X-ray

XRay Images Forepaw

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

14 Images

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Anti-nuclear antibody assay

Images

6 Images

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DSS Histology

Images

8 Images

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Ear epidermis immunophenotyping

Images

12 Images

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Legacy Phenotype Associated Images
Irak1tm1a(EUCOMM)Hmgu
WT, Female, WTSI
Irak1tm1a(EUCOMM)Hmgu
WT, Female, WTSI
Irak1tm1a(EUCOMM)Hmgu
WT, Female, WTSI
Irak1tm1a(EUCOMM)Hmgu
WT, Female, WTSI
Irak1tm1a(EUCOMM)Hmgu
WT, Female, WTSI

View all 91 images

Human diseases caused by Irak1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Irak1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pediatric Systemic Lupus Erythematosus
Antiphospholipid antibody positivity, Antinuclear antibody positivity, Systemic lupus erythematos... ORPHA:93552
Systemic Lupus Erythematosus
Antinuclear antibody positivity, Antineutrophil antibody positivity, Anti-La/SS-B antibody positi... ORPHA:536

The table below shows human diseases predicted to be associated to Irak1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Complement Component 4, Partial Deficiency Of
Systemic lupus erythematosus OMIM:120790
Autoimmune Disease
Autoimmune antibody positivity, Autoimmunity OMIM:109100
Pemphigus Vulgaris, Familial
Autoimmune antibody positivity, Autoimmunity OMIM:169610
Hashimoto Thyroiditis
Autoimmune antibody positivity, Hashimoto thyroiditis OMIM:140300
Tn Polyagglutination Syndrome
Autoimmunity OMIM:300622
Complement Component 8 Deficiency, Type I
Systemic lupus erythematosus OMIM:613790
Systemic Lupus Erythematosus 16
Antinuclear antibody positivity, Perinuclear antineutrophil antibody positivity, Anti-dsDNA antib... OMIM:614420
Complement Component C1S Deficiency
Hashimoto thyroiditis, Systemic lupus erythematosus OMIM:613783
C1Q Deficiency 1
Autoimmunity, Systemic lupus erythematosus OMIM:613652
Complement Component 2 Deficiency
Systemic lupus erythematosus OMIM:217000
Eosinophilopenia
Autoimmunity OMIM:131430
Diabetes Mellitus, Ketosis-Prone
Autoimmunity OMIM:612227
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Autoimmune hemolytic anemia, Autoimmunity, Systemic lupus erythematosus, Autoimmune thrombocytopenia ORPHA:444463
Immunoglobulin A Deficiency 2
Autoimmunity OMIM:609529
Pemphigus Erythematosus
Antinuclear antibody positivity, Anti-acetylcholine receptor antibody positivity, Autoimmunity, S... ORPHA:79480
Sjogren Syndrome
Autoimmunity, Rheumatoid arthritis OMIM:270150
Combined Immunodeficiency Due To Partial Rag1 Deficiency
Autoimmune hemolytic anemia, Neutropenia in presence of anti-neutropil antibodies, Autoimmunity ORPHA:231154
Subcorneal Pustular Dermatosis
Autoimmunity, Rheumatoid arthritis, Systemic lupus erythematosus ORPHA:48377
Pediatric Systemic Lupus Erythematosus
Antiphospholipid antibody positivity, Antinuclear antibody positivity, Systemic lupus erythematos... ORPHA:93552
Infection-Related Hemolytic Uremic Syndrome
Increased circulating interleukin 6 concentration, Abnormality of chemokine secretion, Abnormalit... ORPHA:544482
Systemic Lupus Erythematosus
Antinuclear antibody positivity, Antineutrophil antibody positivity, Anti-La/SS-B antibody positi... ORPHA:536

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Irak1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Irak1.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Irak1tm1a(EUCOMM)Hmgu Irak1tm1b(EUCOMM)Hmgu PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Irak1tm1b(EUCOMM)Hmgu PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Irak1tm1b(EUCOMM)Hmgu PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Irak1tm1b(EUCOMM)Hmgu PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Irak1tm1a(EUCOMM)Hmgu Irak1tm1b(EUCOMM)Hmgu PMC5827107

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Irak1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Irak1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Irak1tm40593(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Irak1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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