Gene: Lefty1

Order

Name left right determination factor 1

Synonyms
  • Stra3
  • lefty-1
  • Ebaf
  • Lefty

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:107405    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Lefty1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Lefty1 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
prenatal lethality Lefty1tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
prenatal lethality prior to heart atrial septation Lefty1tm1b(KOMP)Wtsi HOM Female Male embryonic day 14.5 0.0
preweaning lethality, complete penetrance Lefty1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
abnormal gait Lefty1tm1b(KOMP)Wtsi HET Male postnatal 8.45E-9
hyperactivity Lefty1tm1b(KOMP)Wtsi HET Female postnatal 1.77E-5
increased circulating potassium level Lefty1tm1b(KOMP)Wtsi HET Female Male postnatal 2.94E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Bone 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No
Oral epithelium 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
Vascular system 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    reproductive system
    trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Dorso Ventral
    2 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    2 Images
  • X-ray: XRay Images Lateral Orientation
    2 Images
  • Adult LacZ: LacZ Images Wholemount
    1 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Lefty1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Lefty1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Lefty1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene