Gene: Nsun2

Order

Name NOL1/NOP2/Sun domain family member 2

Synonyms Misu

Status ES CellsMice
tm1a
Mice
tm1c
phenotype data available

Links MGI:107252    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Nsun2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nsun2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
male infertility Nsun2tm1a(EUCOMM)Wtsi HOM Male postpartum stage 0.0
preweaning lethality, incomplete penetrance Nsun2tm1a(EUCOMM)Wtsi HOM Female Male n/a 0.0
decreased body weight Nsun2tm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.49E-39
decreased body weight Nsun2tm1a(EUCOMM)Wtsi HET Female Male postnatal 3.76E-7
decreased circulating amylase level Nsun2tm1a(EUCOMM)Wtsi HET Female Male postnatal 1.12E-5
abnormal snout morphology Nsun2tm1a(EUCOMM)Wtsi HOM Male postnatal 8.36E-5
decreased mean corpuscular volume Nsun2tm1a(EUCOMM)Wtsi HET Female postnatal 9.8E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 6 No (5/6)
Aorta 6 No
Blood vessel 6 No
Bone 6 No (5/6)
Brain 6 No (6/6)
Brainstem 6 No
Brown adipose tissue 6 No
Cartilage tissue 6 No (5/6)
Cerebellum 6 No
Cerebral cortex 6 No
Eye 6 No (5/6)
Gall bladder 6 No (2/6)
Heart 6 No (5/6)
Hippocampus 6 No
Hypothalamus 6 No
Kidney 6 No (18/584) (6/6)
Large intestine 6 No (10/584) (5/6)
Liver 6 No (3/6)
Lower urinary tract 6 No (6/6)
Lung 6 No (5/6)
Lymph node 6 No (5/6)
Mammary gland 6 No
Esophagus 6 No (6/6)
Olfactory lobe 6 No
Ovary 6 No (1/584) (3/6)
Oviduct 6 No (3/6)
Pancreas 6 No (5/584) (6/6)
Parathyroid gland 6 No (4/6)
Peripheral nervous system 6 No (5/6)
Peyer's patch 6 No (4/6)
Pituitary gland 6 No (2/6)
Prostate gland 6 No (12/584) (3/6)
Skeletal muscle tissue 6 No
Skin 6 No (6/6)
Small intestine 6 No (9/584) (5/6)
Spinal cord 6 No (6/6)
Spleen 6 No (2/584) (4/6)
Stomach 6 No (12/584) (6/6)
Striatum 6 No
Testis 6 No (2/584) (2/6)
Thymus 6 No (5/6)
Thyroid gland 6 No (15/584) (4/6)
Trachea 6 No (5/6)
Uterus 6 No (3/6)
White adipose tissue 6 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
postnatal mouse (25)
  • Nsun2tm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    skin, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI

show all 25 images

trunk (16)
  • Nsun2tm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Male, WTSI

show all 16 images

nervous system (5)
  • Nsun2tm1a(EUCOMM)Wtsi
    peripheral nervous system, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    pituitary gland, HET, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    brain, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    spinal cord, HET, Male, WTSI
digestive system (4)
  • Nsun2tm1a(EUCOMM)Wtsi
    large intestine, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    oesophagus, stomach, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    liver, gall bladder, HET, Male, WTSI
immune system (3)
  • Nsun2tm1a(EUCOMM)Wtsi
    lymph node, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    peyer's patch, small intestine, HET, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    thymus, HET, Female, WTSI
reproductive system (3)
  • Nsun2tm1a(EUCOMM)Wtsi
    testis, HET, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    ovary, uterus, oviduct, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    prostate gland, HET, Male, WTSI
endocrine system (2)
  • Nsun2tm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    adrenal gland, HET, Female, WTSI
exocrine system (2)
  • Nsun2tm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    prostate gland, HET, Male, WTSI
integumental system (2)
  • Nsun2tm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    skin, HET, Female, WTSI
respiratory system (2)
  • Nsun2tm1a(EUCOMM)Wtsi
    trachea, thyroid gland, parathyroid gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    lung, HET, Female, WTSI
set of connective tissues (2)
  • Nsun2tm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    cartilage tissue, bone, HET, Female, WTSI
urinary system (2)
  • Nsun2tm1a(EUCOMM)Wtsi
    urinary bladder, lower urinary tract, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    kidney, HET, Male, WTSI
adipose tissue (1)
  • Nsun2tm1a(EUCOMM)Wtsi
    inguinal fat pad, mammary gland, HET, Female, WTSI
cardiovascular system (1)
  • Nsun2tm1a(EUCOMM)Wtsi
    heart, HET, Female, WTSI
musculoskeletal system (1)
  • Nsun2tm1a(EUCOMM)Wtsi
    cartilage tissue, bone, HET, Female, WTSI
sensory organ (1)
  • Nsun2tm1a(EUCOMM)Wtsi
    eye, HET, Female, WTSI

Associated Images

Legacy Phenotype Associated Images
Xray (268)
  • Nsun2tm1a(EUCOMM)Wtsi
    body, WT, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    forearm, WT, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    head, WT, Male, WTSI

show all 268 images

Eye Morphology (6)
  • Nsun2tm1a(EUCOMM)Wtsi
    eye, corneal opacity, abnormal cornea morphology, HOM, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    eye, abnormal cornea morphology, narrow eye opening, excessive tearing, HOM, Male, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    eye, corneal vascularization, narrow eye opening, corneal opacity, corneal ulcer, HOM, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    eye, eyelids fail to open, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    eye, persistence of hyaloid vascular system, HOM, Female, WTSI

show all 6 images

Skin Histopathology (3)
  • Nsun2tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    back skin, HET, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    back skin, HOM, Female, WTSI
Tail Epidermis Wholemount (2)
  • Nsun2tm1a(EUCOMM)Wtsi
    abnormal epidermis stratum basale morphology, HOM, Female, WTSI
  • Nsun2tm1a(EUCOMM)Wtsi
    abnormal epidermis stratum basale morphology, HOM, Female, WTSI

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nsun2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nsun2tm1c(EUCOMM)Wtsi Wild type floxed exon (post-Flp)
Vector
Gene
Nsun2tm42933(L1L2_gt0)
Vector
Gene